Neutrophil-mediated T-Cell Suppression in Influenza: Novel Finding Raising Additional Questions
[...]adoptive transfer of Cd11b+/+, but not Cd11b2/2, neutrophils into Cd11b~/2 mice also mitigated lung injury with a trend toward diminished T-cell proliferation. Additional studies are needed to address whether the same mechanism mediates T-cell suppression by neutrophils during influenza infecti...
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Published in | American journal of respiratory cell and molecular biology Vol. 58; no. 4; pp. 423 - 425 |
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Main Author | |
Format | Journal Article |
Language | English |
Published |
United States
American Thoracic Society
01.04.2018
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Subjects | |
Online Access | Get full text |
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Summary: | [...]adoptive transfer of Cd11b+/+, but not Cd11b2/2, neutrophils into Cd11b~/2 mice also mitigated lung injury with a trend toward diminished T-cell proliferation. Additional studies are needed to address whether the same mechanism mediates T-cell suppression by neutrophils during influenza infection in mice or whether other mechanisms, such as arginine depletion and reactive nitrogen species, induce the effect in a CD11b-dependent manner. Because neutrophil-derived signals are also critical for T-cell recruitment and activation during influenza pneumonia (15), the mechanisms that drive neutrophils or distinct subsets of neutrophils to differentially activate or inhibit T-cell immunity should be explored. Because neutrophils induce T-cell recruitment and activation, and both neutrophils and T cells are cytotoxic, generating a feedforward mechanism of inflammation and lung injury (1), T-cell suppression by neutrophils is likely critical to limit tissue damage by an unchecked immune system during influenza infection. |
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Bibliography: | SourceType-Other Sources-1 content type line 63 ObjectType-Editorial-2 ObjectType-Commentary-1 |
ISSN: | 1044-1549 1535-4989 |
DOI: | 10.1165/rcmb.2017-0425ED |