Transcriptomic Analysis of CD4+ T Cells Reveals Novel Immune Signatures of Latent Tuberculosis

• Published in: The Journal of immunology (1950) Vol. 200; no. 9; pp. 3283 - 3290
• Main Authors: Burel, Julie G, Lindestam Arlehamn, Cecilia S, Khan, Nabeela, Seumois, Grégory, Greenbaum, Jason A, Taplitz, Randy, Gilman, Robert H, Saito, Mayuko, Vijayanand, Pandurangan, Sette, Alessandro, Peters, Bjoern
• Format: Journal Article
• Language: English
• Published: United States American Association of Immunologists 01.05.2018
• Subjects: c-Kit protein; CCR6 protein; CD4 antigen; CXCR3 protein; Epitopes; Immune response; Immunological memory; L-selectin; Lymphocytes; Lymphocytes T; Memory cells; Phenotypes; Ribonucleic acid; RNA; Single-cell protein; T cell receptors; Tuberculosis

In the context of infectious diseases, cell population transcriptomics are useful to gain mechanistic insight into protective immune responses, which is not possible using traditional whole-blood approaches. In this study, we applied a cell population transcriptomics strategy to sorted memory CD4 T...