Effects on sleep stages and microarchitecture of caffeine and its combination with zolpidem or trazodone in healthy volunteers

• Published in: Journal of psychopharmacology (Oxford) Vol. 23; no. 5; p. 487
• Main Authors: Paterson, L M, Nutt, D J, Ivarsson, M, Hutson, P H, Wilson, S J
• Format: Journal Article
• Language: English
• Published: United States 01.07.2009
• Subjects: Adult; Caffeine - toxicity; Central Nervous System Stimulants - toxicity; Cross-Over Studies; Double-Blind Method; Electroencephalography; Humans; Hypnotics and Sedatives - pharmacology; Male; Polysomnography; Pyridines - pharmacology; Sleep Initiation and Maintenance Disorders - chemically induced; Sleep Initiation and Maintenance Disorders - drug therapy; Sleep Stages - drug effects; Trazodone - pharmacology; Young Adult

Caffeine is the world's most popular stimulant and is known to disrupt sleep. Administration of caffeine can therefore be used in healthy volunteers to mimic the effects of insomnia and thus to test the hypnotic effects of medication. This study assessed the effects of caffeine on sleep archite...