Fyn tyrosine kinase, a downstream target of receptor tyrosine kinases, modulates antiglioma immune responses

• Published in: Neuro-oncology (Charlottesville, Va.) Vol. 22; no. 6; pp. 806 - 818
• Main Authors: Comba, Andrea, Dunn, Patrick J, Argento, Anna E, Kadiyala, Padma, Ventosa, Maria, Patel, Priti, Zamler, Daniel B, Núñez, Felipe J, Zhao, Lili, Castro, Maria G, Lowenstein, Pedro R
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 09.06.2020
• Subjects: Animals; Basic and Translational Investigations; Brain Neoplasms - genetics; Glioma - genetics; Immunity; Mice; Proto-Oncogene Proteins c-fyn - genetics; Receptor Protein-Tyrosine Kinases; Tumor Microenvironment; Fyn tyrosine kinase; glioma; antitumor immune responses; myeloid-derived suppressor cells

Abstract Background High-grade gliomas are aggressive and immunosuppressive brain tumors. Molecular mechanisms that regulate the inhibitory immune tumor microenvironment (TME) and glioma progression remain poorly understood. Fyn tyrosine kinase is a downstream target of the oncogenic receptor tyrosi...