Pharmacological Modulation of Sleep Homeostasis in Rat: Novel Effects of an mGluR2/3 Antagonist

• Published in: Sleep (New York, N.Y.) Vol. 42; no. 9; p. 1
• Main Authors: Hanley, Nicola, Paulissen, Jerome, Eastwood, Brian J, Gilmour, Gary, Loomis, Sally, Wafford, Keith A, McCarthy, Andrew
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 06.09.2019
• Subjects: Amphetamines; Caffeine; Central nervous system agents; Dextroamphetamine; Disabilities; Eye movements; Glutamate; Homeostasis; NREM sleep; Pharmacology; Power (Philosophy); Public relations executives; Purines; REM sleep; Sleep; Sleep disorders; sleep deprivation; nonlinear analysis; NREM–REM cycles; EEG spectral analysis; neuropharmacology; pharmacology—wake-promoting agents

Increasing vigilance without incurring the negative consequences of extended wakefulness such as daytime sleepiness and cognitive impairment is a major challenge in treating many sleep disorders. The present work compares two closely related mGluR2/3 antagonists LY3020371 and LY341495 with two well-...