The gene: An appraisal
The gene can be described as the foundational concept of modern biology. As such, it has spilled over into daily discourse, yet it is acknowledged among biologists to be ill-defined. Here, following a short history of the gene, I analyse critically its role in inheritance, evolution, development, an...
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| Published in | Progress in biophysics and molecular biology Vol. 164; pp. 46 - 62 |
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| Main Author | |
| Format | Journal Article |
| Language | English |
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England
Elsevier Ltd
01.09.2021
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| Abstract | The gene can be described as the foundational concept of modern biology. As such, it has spilled over into daily discourse, yet it is acknowledged among biologists to be ill-defined. Here, following a short history of the gene, I analyse critically its role in inheritance, evolution, development, and morphogenesis. Wilhelm Johannsen's genotype-conception, formulated in 1910, has been adopted as the foundation stone of genetics, giving the gene a higher degree of prominence than is justified by the evidence. An analysis of the results of the Long-Term Evolution Experiment (LTEE) with E. coli bacteria, grown over 60,000 generations, does not support spontaneous gene mutation as the source of variance for natural selection. From this it follows that the gene is not Mendel's unit of inheritance: that must be Johannsen's transmission-conception at the gamete phenotype level, a form of inheritance that Johannsen did not consider. Alternatively, I contend that biology viewed on the bases of thermodynamics, complex system dynamics and self-organisation, provides a new framework for the foundations of biology. In this framework, the gene plays a passive role as a vital information store: it is the phenotype that plays the active role in inheritance, evolution, development, and morphogenesis. |
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| AbstractList | The gene can be described as the foundational concept of modern biology. As such, it has spilled over into daily discourse, yet it is acknowledged among biologists to be ill-defined. Here, following a short history of the gene, I analyse critically its role in inheritance, evolution, development, and morphogenesis. Wilhelm Johannsen's genotype-conception, formulated in 1910, has been adopted as the foundation stone of genetics, giving the gene a higher degree of prominence than is justified by the evidence. An analysis of the results of the Long-Term Evolution Experiment (LTEE) with E. coli bacteria, grown over 60,000 generations, does not support spontaneous gene mutation as the source of variance for natural selection. From this it follows that the gene is not Mendel's unit of inheritance: that must be Johannsen's transmission-conception at the gamete phenotype level, a form of inheritance that Johannsen did not consider. Alternatively, I contend that biology viewed on the bases of thermodynamics, complex system dynamics and self-organisation, provides a new framework for the foundations of biology. In this framework, the gene plays a passive role as a vital information store: it is the phenotype that plays the active role in inheritance, evolution, development, and morphogenesis. The gene can be described as the foundational concept of modern biology. As such, it has spilled over into daily discourse, yet it is acknowledged among biologists to be ill-defined. Here, following a short history of the gene, I analyse critically its role in inheritance, evolution, development, and morphogenesis. Wilhelm Johannsen's genotype-conception, formulated in 1910, has been adopted as the foundation stone of genetics, giving the gene a higher degree of prominence than is justified by the evidence. An analysis of the results of the Long-Term Evolution Experiment (LTEE) with E. coli bacteria, grown over 60,000 generations, does not support spontaneous gene mutation as the source of variance for natural selection. From this it follows that the gene is not Mendel's unit of inheritance: that must be Johannsen's transmission-conception at the gamete phenotype level, a form of inheritance that Johannsen did not consider. Alternatively, I contend that biology viewed on the bases of thermodynamics, complex system dynamics and self-organisation, provides a new framework for the foundations of biology. In this framework, the gene plays a passive role as a vital information store: it is the phenotype that plays the active role in inheritance, evolution, development, and morphogenesis.The gene can be described as the foundational concept of modern biology. As such, it has spilled over into daily discourse, yet it is acknowledged among biologists to be ill-defined. Here, following a short history of the gene, I analyse critically its role in inheritance, evolution, development, and morphogenesis. Wilhelm Johannsen's genotype-conception, formulated in 1910, has been adopted as the foundation stone of genetics, giving the gene a higher degree of prominence than is justified by the evidence. An analysis of the results of the Long-Term Evolution Experiment (LTEE) with E. coli bacteria, grown over 60,000 generations, does not support spontaneous gene mutation as the source of variance for natural selection. From this it follows that the gene is not Mendel's unit of inheritance: that must be Johannsen's transmission-conception at the gamete phenotype level, a form of inheritance that Johannsen did not consider. Alternatively, I contend that biology viewed on the bases of thermodynamics, complex system dynamics and self-organisation, provides a new framework for the foundations of biology. In this framework, the gene plays a passive role as a vital information store: it is the phenotype that plays the active role in inheritance, evolution, development, and morphogenesis. |
| Author | Baverstock, Keith |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33979646$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1038/s41467-019-09521-2 10.1126/science.177.4047.393 10.1016/j.devcel.2019.05.019 10.1016/j.mrrev.2012.12.001 10.3389/fgene.2013.00216 10.1038/nrg2809 10.1534/genetics.118.301594 10.15698/mic2019.08.688 10.1016/j.celrep.2019.12.060 10.1038/nature08494 10.1016/j.tree.2018.02.007 10.1016/j.pbiomolbio.2019.08.004 10.1002/bies.950120908 10.1080/19420889.2016.1238118 10.2190/HS.43.2.f 10.1038/srep11548 10.1038/nature17948 10.1007/s00018-018-2894-9 10.1098/rsif.2013.1017 10.1002/gepi.22165 10.1126/science.aax0164 10.1016/j.ajhg.2019.05.001 10.1086/279629 10.1371/journal.pgen.1006668 10.1016/j.tibs.2019.12.005 10.1093/ije/dyu066 10.1128/JB.00831-15 10.1038/355738a0 10.1007/s00018-012-1148-5 10.1038/227561a0 10.1016/S0092-8240(05)80008-4 10.1073/pnas.47.9.1309 10.1073/pnas.91.15.6808 10.1016/S0065-2660(01)42013-X 10.1128/jb.151.1.269-273.1982 10.1016/j.plrev.2010.10.001 10.1176/appi.ajp.2018.18070881 10.1016/j.cell.2011.02.045 10.1002/bies.201600084 10.7554/eLife.20320 10.1038/nrg1654 10.1038/d41586-021-00314-6 10.1534/genetics.116.196956 10.1016/S0375-9601(99)00532-0 10.1080/19420889.2019.1594501 10.1371/journal.pone.0002290 10.1126/science.1063443 10.1007/s13752-020-00356-5 10.1126/science.15739260 10.1098/rsfs.2016.0135 10.1080/19420889.2016.1187348 10.1242/jcs.03063 10.1016/j.mrgentox.2012.06.010 10.1108/14636681011049848 10.1038/150563a0 10.1016/S0022-2836(61)80072-7 10.3389/fpsyg.2016.00902 10.1073/pnas.0912629107 10.1093/ije/dyx129 10.1093/aob/mcz155 10.1667/0033-7587(2003)159[0581:NADEOE]2.0.CO;2 10.1162/biot.2008.3.3.258 10.1371/journal.pone.0058284 10.1534/g3.117.300217 10.1016/j.pbiomolbio.2011.01.002 10.4161/cib.2.1.7620 10.1111/j.1749-6632.2001.tb05705.x 10.1016/j.pbiomolbio.2012.09.003 10.1016/0968-0004(88)90138-7 10.1016/S0027-5107(00)00100-7 10.1007/s00285-017-1190-x 10.1016/j.bpc.2007.01.005 10.1038/nature08480 10.1093/gbe/evaa178 10.1093/ije/dyaa288 10.1113/jphysiol.2014.271775 10.1207/s15327957pspr0203_4 10.1016/j.newideapsych.2019.04.005 10.1017/S0080456800012163 10.1038/ncb3347 10.1016/S0092-8674(00)00128-8 10.1162/artl.2007.13.2.159 10.1038/nature24287 10.1093/icb/4.4.443 10.1667/0033-7587(2003)159[0567:NADEOE]2.0.CO;2 10.1111/1467-9884.00362 10.1126/science.1243357 10.1086/279202 |
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| Keywords | Development and morphogenesis Evolution Phenotype as unit of inheritance Genotype-conception LTEE and Power law Inheritance |
| Language | English |
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| References | Rosen (bib95) 1991 Blyth (bib22) 1835; 8 Baverstock (bib14) 2019; 12 Waddington (bib111) 2008; 3 Gates, Gysi, Kellis, Barabasi (bib43) 2021; 590 Richardson (bib91) 2020; 15 Salek, Carrara, Fernandez, Guasto, Stocker (bib96) 2019; 10 Anderson (bib2) 1972; 177 Baverstock (bib12) 2000; 454 Crick (bib29) 1970; 227 Rice, Borecki (bib88) 2001; 42 Basener, Sanford (bib11) 2018; 76 Salek, Carrara, Fernandez, Stocker (bib97) 2019; 6 Jacob, Monod (bib51) 1961; 3 Kerminen, Martin, Koskela, Ruotsalainen, Havulinna, Surakka, Palotie, Perola, Salomaa, Daly, Ripatti, Pirinen (bib60) 2019; 104 Nurse, Hayles (bib80) 2011; 144 Baverstock (bib13) 2011; 106 Oparin (bib83) 1953 Morgan (bib74) 1917; 51 Sharma, Annila (bib104) 2007; 127 Timoféeff-Ressovsky, Zimmer, Delbrück (bib105) 1935; vol. 1 Schweisguth, Corson (bib101) 2019; 49 Eichler, Flint, Gibson, Kong, Leal, Moore, Nadeau (bib38) 2010; 11 Oliveira, Melo (bib81) 2015; 5 Joseph (bib55) 2015 Maddamsetti, Grant (bib68) 2020; 12 Waddington (bib110) 1942; 150 Fisher (bib41) 1930 Jelenkovic, Hur, Sund, Yokoyama, Siribaddana, Hotopf, Sumathipala, Rijsdijk, Tan, Zhang, Pang, Aaltonen, Heikkila, Oncel, Aliev, Rebato, Tarnoki, Tarnoki, Christensen, Skytthe, Kyvik, Silberg, Eaves, Maes, Cutler, Hopper, Ordonana, Sanchez-Romera, Colodro-Conde, Cozen, Hwang, Mack, Sung, Song, Yang, Lee, Franz, Kremen, Lyons, Busjahn, Nelson, Whitfield, Kandler, Jang, Gatz, Butler, Stazi, Fagnani, D'Ippolito, Duncan, Buchwald, Derom, Vlietinck, Loos, Martin, Medland, Montgomery, Jeong, Swan, Krasnow, Magnusson, Pedersen, Dahl-Aslan, McAdams, Eley, Gregory, Tynelius, Baker, Tuvblad, Bayasgalan, Narandalai, Lichtenstein, Spector, Mangino, Lachance, Bartels, van Beijsterveldt, Willemsen, Burt, Klump, Harris, Brandt, Nilsen, Krueger, McGue, Pahlen, Corley, Hjelmborg, Goldberg, Iwatani, Watanabe, Honda, Inui, Rasmussen, Huibregtse, Boomsma, Sorensen, Kaprio, Silventoinen (bib52) 2016; 5 Scott (bib100) 2007 Border, Johnson, Evans, Smolen, Berley, Sullivan, Keller (bib24) 2019; 176 Jablonka (bib50) 2017; 7 Deglincerti, Croft, Pietila, Zernicka-Goetz, Siggia, Brivanlou (bib35) 2016; 533 Lynch (bib67) 2010; 107 De la Fuente, Cortes, Pelta, Veguillas (bib33) 2013; 8 Gell-Mann (bib44) 2001; 929 Noble (bib79) 2017 Black (bib20) 2000; 103 Fisher (bib40) 1918; 52 Grafen (bib47) 2003; 42 Bertalanffy (bib19) 1969 Niemann (bib77) 2014 Portin, Wilkins (bib85) 2017; 205 Van Hofwegen, Hovde, Minnich (bib107) 2016; 198 Lewontin (bib65) 1974 Minton (bib73) 2006; 119 Johannsen (bib53) 1911; 45 Baluska, Yokawa, Mancuso, Baverstock (bib9) 2016; 9 Krawetz (bib62) 2005; 6 Rose (bib94) 1988; 13 Shahbazi, Jedrusik, Vuoristo, Recher, Hupalowska, Bolton, Fogarty, Campbell, Devito, Ilic, Khalaf, Niakan, Fishel, Zernicka-Goetz (bib102) 2016; 18 Baverstock, Ronkko (bib17) 2014; 592 Pujol, Blanchet, Charmantier, Danchin, Facon, Marrot, Roux, Scotti, Teplitsky, Thomson, Winney (bib86) 2018; 33 Karotki, Baverstock (bib58) 2012; 69 Bray (bib25) 2009 Plomin (bib84) 2018 Baluska, Levin (bib7) 2016; 7 Schrödinger (bib99) 1944 Makela, Annila (bib69) 2010; 7 Richardson, Jones (bib90) 2019; 55 Baverstock, Karotki (bib16) 2011; 718 Manolio, Collins, Cox, Goldstein, Hindorff, Hunter, McCarthy, Ramos, Cardon, Chakravarti, Cho, Guttmacher, Kong, Kruglyak, Mardis, Rotimi, Slatkin, Valle, Whittemore, Boehnke, Clark, Eichler, Gibson, Haines, Mackay, McCarroll, Visscher (bib70) 2009; 461 Annila, Baverstock (bib5) 2014; 11 Kerr (bib61) 1998; 2 Visscher, Goddard (bib109) 2019; 211 Good, McDonald, Barrick, Lenski, Desai (bib46) 2017; 551 Visscher, Bruce Walsh (bib108) 2019; 48 McClintock (bib72) 1984; 226 Alabert, Loos, Voelker-Albert, Graziano, Forne, Reveron-Gomez, Schuh, Hasenauer, Marr, Imhof, Groth (bib1) 2020; 30 Louie (bib66) 2010; 12 Csermely, Kunsic, Mendik, Kerestely, Farago, Veres, Tompa (bib30) 2020; 45 De Maupertuis (bib34) 1746 Reik, Dean, Walter (bib87) 2001; 293 Hall (bib48) 1982; 151 Omholt (bib82) 2013; 111 Annila, Baverstock (bib6) 2016; 9 Baverstock, Rönkkö (bib18) 2008; 3 Yang (bib113) 1999; 260 Dyson (bib37) 1999 Baverstock (bib15) 2019; 149 Lenski, Travisano (bib64) 1994; 91 Calvo, Gagliano, Souza, Trewavas (bib26) 2020; 125 Morgan (bib76) 2003; 159 Sanderson, Richardson, Hemani, Davey Smith (bib98) 2021 Turing (bib106) 1990; 52 Dobzhansky (bib36) 1964; 4 Kadhim, Macdonald, Goodhead, Lorimore, Marsden, Wright (bib56) 1992; 355 Darwin, Kebler (bib31) 1859 Baluska, Mancuso (bib8) 2009; 2 Dawkins (bib32) 2009 Lenski (bib63) 2017; 13 Boltzmann (bib23) 1974 Kadhim, Salomaa, Wright, Hildebrandt, Belyakov, Prise, Little (bib57) 2013; 752 Shahbazi, Siggia, Zernicka-Goetz (bib103) 2019; 364 Crick (bib28) 1958; 12 Huumonen, Immonen, Baverstock, Hiltunen, Korkalainen, Lahtinen, Parviainen, Viluksela, Wong, Naarala, Juutilainen (bib49) 2012; 748 Gjuvsland, Wang, Plahte, Omholt (bib45) 2013; 4 Nijhout (bib78) 1990; 12 Chaufan, Joseph (bib27) 2013; 43 Blanco-Gomez, Castillo-Lluva, Del Mar Saez-Freire, Hontecillas-Prieto, Mao, Castellanos-Martin, Perez-Losada (bib21) 2016; 38 Annila (bib4) 2020 Wiser, Ribeck, Lenski (bib112) 2013; 342 Richardson (bib89) 2017 Anfinsen, Haber, Sela, White (bib3) 1961; 47 Barrick, Yu, Yoon, Jeong, Oh, Schneider, Lenski, Kim (bib10) 2009; 461 Ronkko (bib93) 2007; 13 Elston (bib39) 2018; 42 Kerminen, Havulinna, Hellenthal, Martin, Sarin, Perola, Palotie, Salomaa, Daly, Ripatti, Pirinen (bib59) 2017; 7 Mayr (bib71) 2001 Fonin, Darling, Kuznetsova, Turoverov, Uversky (bib42) 2018; 75 Morgan (bib75) 2003; 159 Roll-Hansen (bib92) 2014; 43 Baverstock (10.1016/j.pbiomolbio.2021.04.005_bib16) 2011; 718 Gell-Mann (10.1016/j.pbiomolbio.2021.04.005_bib44) 2001; 929 Lenski (10.1016/j.pbiomolbio.2021.04.005_bib64) 1994; 91 Pujol (10.1016/j.pbiomolbio.2021.04.005_bib86) 2018; 33 Lenski (10.1016/j.pbiomolbio.2021.04.005_bib63) 2017; 13 Sanderson (10.1016/j.pbiomolbio.2021.04.005_bib98) 2021 Dyson (10.1016/j.pbiomolbio.2021.04.005_bib37) 1999 Plomin (10.1016/j.pbiomolbio.2021.04.005_bib84) 2018 Lynch (10.1016/j.pbiomolbio.2021.04.005_bib67) 2010; 107 Niemann (10.1016/j.pbiomolbio.2021.04.005_bib77) 2014 Visscher (10.1016/j.pbiomolbio.2021.04.005_bib108) 2019; 48 Anfinsen (10.1016/j.pbiomolbio.2021.04.005_bib3) 1961; 47 Richardson (10.1016/j.pbiomolbio.2021.04.005_bib90) 2019; 55 Grafen (10.1016/j.pbiomolbio.2021.04.005_bib47) 2003; 42 Kadhim (10.1016/j.pbiomolbio.2021.04.005_bib56) 1992; 355 Turing (10.1016/j.pbiomolbio.2021.04.005_bib106) 1990; 52 Waddington (10.1016/j.pbiomolbio.2021.04.005_bib110) 1942; 150 Bertalanffy (10.1016/j.pbiomolbio.2021.04.005_bib19) 1969 Baluska (10.1016/j.pbiomolbio.2021.04.005_bib7) 2016; 7 Morgan (10.1016/j.pbiomolbio.2021.04.005_bib75) 2003; 159 Nurse (10.1016/j.pbiomolbio.2021.04.005_bib80) 2011; 144 Fisher (10.1016/j.pbiomolbio.2021.04.005_bib41) 1930 Crick (10.1016/j.pbiomolbio.2021.04.005_bib28) 1958; 12 Dawkins (10.1016/j.pbiomolbio.2021.04.005_bib32) 2009 Annila (10.1016/j.pbiomolbio.2021.04.005_bib6) 2016; 9 Lewontin (10.1016/j.pbiomolbio.2021.04.005_bib65) 1974 Black (10.1016/j.pbiomolbio.2021.04.005_bib20) 2000; 103 Waddington (10.1016/j.pbiomolbio.2021.04.005_bib111) 2008; 3 Kerminen (10.1016/j.pbiomolbio.2021.04.005_bib59) 2017; 7 Rosen (10.1016/j.pbiomolbio.2021.04.005_bib95) 1991 Rice (10.1016/j.pbiomolbio.2021.04.005_bib88) 2001; 42 Maddamsetti (10.1016/j.pbiomolbio.2021.04.005_bib68) 2020; 12 Oparin (10.1016/j.pbiomolbio.2021.04.005_bib83) 1953 Annila (10.1016/j.pbiomolbio.2021.04.005_bib4) 2020 Jacob (10.1016/j.pbiomolbio.2021.04.005_bib51) 1961; 3 Morgan (10.1016/j.pbiomolbio.2021.04.005_bib76) 2003; 159 Elston (10.1016/j.pbiomolbio.2021.04.005_bib39) 2018; 42 Jablonka (10.1016/j.pbiomolbio.2021.04.005_bib50) 2017; 7 Krawetz (10.1016/j.pbiomolbio.2021.04.005_bib62) 2005; 6 Blanco-Gomez (10.1016/j.pbiomolbio.2021.04.005_bib21) 2016; 38 Roll-Hansen (10.1016/j.pbiomolbio.2021.04.005_bib92) 2014; 43 Baverstock (10.1016/j.pbiomolbio.2021.04.005_bib17) 2014; 592 Timoféeff-Ressovsky (10.1016/j.pbiomolbio.2021.04.005_bib105) 1935; vol. 1 Manolio (10.1016/j.pbiomolbio.2021.04.005_bib70) 2009; 461 Minton (10.1016/j.pbiomolbio.2021.04.005_bib73) 2006; 119 Johannsen (10.1016/j.pbiomolbio.2021.04.005_bib53) 1911; 45 Visscher (10.1016/j.pbiomolbio.2021.04.005_bib109) 2019; 211 Deglincerti (10.1016/j.pbiomolbio.2021.04.005_bib35) 2016; 533 Baverstock (10.1016/j.pbiomolbio.2021.04.005_bib14) 2019; 12 Schrödinger (10.1016/j.pbiomolbio.2021.04.005_bib99) 1944 Good (10.1016/j.pbiomolbio.2021.04.005_bib46) 2017; 551 Mayr (10.1016/j.pbiomolbio.2021.04.005_bib71) 2001 Joseph (10.1016/j.pbiomolbio.2021.04.005_bib55) 2015 Hall (10.1016/j.pbiomolbio.2021.04.005_bib48) 1982; 151 Barrick (10.1016/j.pbiomolbio.2021.04.005_bib10) 2009; 461 Baverstock (10.1016/j.pbiomolbio.2021.04.005_bib12) 2000; 454 Anderson (10.1016/j.pbiomolbio.2021.04.005_bib2) 1972; 177 Eichler (10.1016/j.pbiomolbio.2021.04.005_bib38) 2010; 11 Wiser (10.1016/j.pbiomolbio.2021.04.005_bib112) 2013; 342 Kadhim (10.1016/j.pbiomolbio.2021.04.005_bib57) 2013; 752 Baverstock (10.1016/j.pbiomolbio.2021.04.005_bib15) 2019; 149 Van Hofwegen (10.1016/j.pbiomolbio.2021.04.005_bib107) 2016; 198 Salek (10.1016/j.pbiomolbio.2021.04.005_bib97) 2019; 6 Makela (10.1016/j.pbiomolbio.2021.04.005_bib69) 2010; 7 Yang (10.1016/j.pbiomolbio.2021.04.005_bib113) 1999; 260 Shahbazi (10.1016/j.pbiomolbio.2021.04.005_bib102) 2016; 18 Kerr (10.1016/j.pbiomolbio.2021.04.005_bib61) 1998; 2 Salek (10.1016/j.pbiomolbio.2021.04.005_bib96) 2019; 10 Chaufan (10.1016/j.pbiomolbio.2021.04.005_bib27) 2013; 43 Omholt (10.1016/j.pbiomolbio.2021.04.005_bib82) 2013; 111 Fonin (10.1016/j.pbiomolbio.2021.04.005_bib42) 2018; 75 Gates (10.1016/j.pbiomolbio.2021.04.005_bib43) 2021; 590 Ronkko (10.1016/j.pbiomolbio.2021.04.005_bib93) 2007; 13 Rose (10.1016/j.pbiomolbio.2021.04.005_bib94) 1988; 13 Baluska (10.1016/j.pbiomolbio.2021.04.005_bib8) 2009; 2 Morgan (10.1016/j.pbiomolbio.2021.04.005_bib74) 1917; 51 Baverstock (10.1016/j.pbiomolbio.2021.04.005_bib13) 2011; 106 Kerminen (10.1016/j.pbiomolbio.2021.04.005_bib60) 2019; 104 Basener (10.1016/j.pbiomolbio.2021.04.005_bib11) 2018; 76 Jelenkovic (10.1016/j.pbiomolbio.2021.04.005_bib52) 2016; 5 Louie (10.1016/j.pbiomolbio.2021.04.005_bib66) 2010; 12 Blyth (10.1016/j.pbiomolbio.2021.04.005_bib22) 1835; 8 Border (10.1016/j.pbiomolbio.2021.04.005_bib24) 2019; 176 Crick (10.1016/j.pbiomolbio.2021.04.005_bib29) 1970; 227 Annila (10.1016/j.pbiomolbio.2021.04.005_bib5) 2014; 11 Darwin (10.1016/j.pbiomolbio.2021.04.005_bib31) 1859 Dobzhansky (10.1016/j.pbiomolbio.2021.04.005_bib36) 1964; 4 Alabert (10.1016/j.pbiomolbio.2021.04.005_bib1) 2020; 30 Bray (10.1016/j.pbiomolbio.2021.04.005_bib25) 2009 Calvo (10.1016/j.pbiomolbio.2021.04.005_bib26) 2020; 125 Fisher (10.1016/j.pbiomolbio.2021.04.005_bib40) 1918; 52 Gjuvsland (10.1016/j.pbiomolbio.2021.04.005_bib45) 2013; 4 Richardson (10.1016/j.pbiomolbio.2021.04.005_bib89) 2017 Huumonen (10.1016/j.pbiomolbio.2021.04.005_bib49) 2012; 748 Shahbazi (10.1016/j.pbiomolbio.2021.04.005_bib103) 2019; 364 De la Fuente (10.1016/j.pbiomolbio.2021.04.005_bib33) 2013; 8 Boltzmann (10.1016/j.pbiomolbio.2021.04.005_bib23) 1974 Richardson (10.1016/j.pbiomolbio.2021.04.005_bib91) 2020; 15 McClintock (10.1016/j.pbiomolbio.2021.04.005_bib72) 1984; 226 Scott (10.1016/j.pbiomolbio.2021.04.005_bib100) 2007 De Maupertuis (10.1016/j.pbiomolbio.2021.04.005_bib34) 1746 Oliveira (10.1016/j.pbiomolbio.2021.04.005_bib81) 2015; 5 Reik (10.1016/j.pbiomolbio.2021.04.005_bib87) 2001; 293 Noble (10.1016/j.pbiomolbio.2021.04.005_bib79) 2017 Sharma (10.1016/j.pbiomolbio.2021.04.005_bib104) 2007; 127 Baverstock (10.1016/j.pbiomolbio.2021.04.005_bib18) 2008; 3 Nijhout (10.1016/j.pbiomolbio.2021.04.005_bib78) 1990; 12 Csermely (10.1016/j.pbiomolbio.2021.04.005_bib30) 2020; 45 Schweisguth (10.1016/j.pbiomolbio.2021.04.005_bib101) 2019; 49 Baluska (10.1016/j.pbiomolbio.2021.04.005_bib9) 2016; 9 Karotki (10.1016/j.pbiomolbio.2021.04.005_bib58) 2012; 69 Portin (10.1016/j.pbiomolbio.2021.04.005_bib85) 2017; 205 |
| References_xml | – year: 2009 ident: bib32 article-title: The Greatest Show on Earth : the Evidence for Evolution – volume: 9 year: 2016 ident: bib9 article-title: Understanding of anesthesia - why consciousness is essential for life and not based on genes publication-title: Commun. Integr. Biol. – volume: 144 start-page: 850 year: 2011 end-page: 854 ident: bib80 article-title: The cell in an era of systems biology publication-title: Cell – volume: 551 start-page: 45 year: 2017 end-page: 50 ident: bib46 article-title: The dynamics of molecular evolution over 60,000 generations publication-title: Nature – volume: 260 start-page: 340 year: 1999 end-page: 344 ident: bib113 article-title: Concepts of synchronization in dynamical systems publication-title: Phys. Lett. – volume: 198 start-page: 1022 year: 2016 end-page: 1034 ident: bib107 article-title: Rapid evolution of citrate utilization by Escherichia coli by direct selection requires citT and dctA publication-title: J. Bacteriol. – volume: 76 start-page: 1589 year: 2018 end-page: 1622 ident: bib11 article-title: The fundamental theorem of natural selection with mutations publication-title: J. Math. Biol. – volume: 2 start-page: 60 year: 2009 end-page: 65 ident: bib8 article-title: Deep evolutionary origins of neurobiology: turning the essence of 'neural' upside-down publication-title: Commun. Integr. Biol. – volume: 45 start-page: 129 year: 1911 end-page: 159 ident: bib53 article-title: The genotype cconception of heredity publication-title: Am. Nat. – volume: 12 start-page: 441 year: 1990 end-page: 446 ident: bib78 article-title: Metaphors and the role of genes in development publication-title: Bioessays – volume: 125 start-page: 11 year: 2020 end-page: 28 ident: bib26 article-title: Plants are intelligent, here's how publication-title: Ann. Bot. – volume: 6 start-page: 370 year: 2019 end-page: 372 ident: bib97 article-title: Bacterial maze runners reveal hidden diversity in chemotactic performance publication-title: Microb. Cell – volume: 75 start-page: 3907 year: 2018 end-page: 3929 ident: bib42 article-title: Intrinsically disordered proteins in crowded milieu: when chaos prevails within the cellular gumbo publication-title: Cell. Mol. Life Sci. – volume: 111 start-page: 75 year: 2013 end-page: 82 ident: bib82 article-title: From sequence to consequence and back publication-title: Prog. Biophys. Mol. Biol. – volume: 454 start-page: 89 year: 2000 end-page: 109 ident: bib12 article-title: Radiation-induced genomic instability: a paradigm-breaking phenomenon and its relevance to environmentally induced cancer publication-title: Mutat. Res. – year: 1974 ident: bib23 article-title: Theoretical Physics and Philosophical Problems : Selected Writings – year: 1991 ident: bib95 article-title: Life Itself: a Comprehensive Inquiry into the Nature, Origin and Fabrication of Life – volume: 342 start-page: 1364 year: 2013 end-page: 1367 ident: bib112 article-title: Long-term dynamics of adaptation in asexual populations publication-title: Science – volume: 2 start-page: 196 year: 1998 end-page: 217 ident: bib61 article-title: HARKing: hypothesizing after the results are known publication-title: Pers. Soc. Psychol. Rev. – volume: 7 start-page: 477 year: 2010 end-page: 498 ident: bib69 article-title: Natural patterns of energy dispersal publication-title: Phys. Life Rev. – volume: 48 start-page: 10 year: 2019 end-page: 12 ident: bib108 article-title: Commentary: Fisher 1918: the foundation of the genetics and analysis of complex traits publication-title: Int. J. Epidemiol. – volume: 38 start-page: 664 year: 2016 end-page: 673 ident: bib21 article-title: Missing heritability of complex diseases: enlightenment by genetic variants from intermediate phenotypes publication-title: Bioessays – volume: 52 start-page: 153 year: 1990 end-page: 197 ident: bib106 article-title: The chemical basis of morphogenesis publication-title: Bull. Math. Biol. – volume: 7 start-page: 3459 year: 2017 end-page: 3468 ident: bib59 article-title: Fine-scale genetic structure in Finland publication-title: G3 (Bethesda) – volume: 91 start-page: 6808 year: 1994 end-page: 6814 ident: bib64 article-title: Dynamics of adaptation and diversification: a 10,000-generation experiment with bacterial populations publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 45 start-page: 284 year: 2020 end-page: 294 ident: bib30 article-title: Learning of signaling networks: molecular mechanisms publication-title: Trends Biochem. Sci. – volume: 748 start-page: 36 year: 2012 end-page: 41 ident: bib49 article-title: Radiation-induced genomic instability in Caenorhabditis elegans publication-title: Mutat. Res. – volume: 12 start-page: 18 year: 2010 end-page: 29 ident: bib66 article-title: Robert Rosen's anticipatory systems publication-title: Foresight – volume: 929 start-page: 41 year: 2001 end-page: 49 ident: bib44 article-title: Consciousness, reduction, and emergence. Some remarks publication-title: Ann. N. Y. Acad. Sci. – start-page: 267 year: 1746 end-page: 294 ident: bib34 article-title: Les Loix du mouvement et du repos deduites d’un principe metaphysique publication-title: Histoire de l’Acad. Roy. Sci. Belles Lett. – year: 1999 ident: bib37 article-title: Origins of Life – volume: 293 start-page: 1089 year: 2001 end-page: 1093 ident: bib87 article-title: Epigenetic reprogramming in mammalian development publication-title: Science – volume: 51 start-page: 513 year: 1917 end-page: 544 ident: bib74 article-title: The theory of the gene publication-title: Am. Nat. – volume: 43 start-page: 1007 year: 2014 end-page: 1013 ident: bib92 article-title: Commentary: Wilhelm Johannsen and the problem of heredity at the turn of the 19th century publication-title: Int. J. Epidemiol. – volume: 10 start-page: 1877 year: 2019 ident: bib96 article-title: Bacterial chemotaxis in a microfluidic T-maze reveals strong phenotypic heterogeneity in chemotactic sensitivity publication-title: Nat. Commun. – volume: 9 year: 2016 ident: bib6 article-title: Discourse on order vs. disorder publication-title: Commun. Integr. Biol. – volume: 3 start-page: 318 year: 1961 end-page: 356 ident: bib51 article-title: Genetic regulatory mechanisms in the synthesis of proteins publication-title: J. Mol. Biol. – volume: 364 start-page: 948 year: 2019 end-page: 951 ident: bib103 article-title: Self-organization of stem cells into embryos: a window on early mammalian development publication-title: Science – volume: 47 start-page: 1309 year: 1961 end-page: 1314 ident: bib3 article-title: The kinetics of formation of native ribonuclease during oxidation of the reduced polypeptide chain publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 11 start-page: 20131017 year: 2014 ident: bib5 article-title: Genes without prominence: a reappraisal of the foundations of biology publication-title: J. R. Soc. Interface – volume: 55 start-page: 35 year: 2019 end-page: 41 ident: bib90 article-title: Why genome-wide associations with cognitive ability measures are probably spurious publication-title: New Ideas Psychol. – volume: 4 start-page: 216 year: 2013 ident: bib45 article-title: Monotonicity is a key feature of genotype-phenotype maps publication-title: Front. Genet. – volume: vol. 1 start-page: 189 year: 1935 end-page: 241 ident: bib105 publication-title: Über die Natur der Genmutation und der Genstruktur – volume: 227 start-page: 561 year: 1970 end-page: 563 ident: bib29 article-title: Central dogma of molecular biology publication-title: Nature – volume: 752 start-page: 84 year: 2013 end-page: 98 ident: bib57 article-title: Non-targeted effects of ionising radiation--implications for low dose risk publication-title: Mutat. Res. – year: 2021 ident: bib98 article-title: The use of negative control outcomes in Mendelian randomization to detect potential population stratification publication-title: Int. J. Epidemiol. – year: 1969 ident: bib19 article-title: General System Theory; Foundations, Development, Applications – volume: 103 start-page: 367 year: 2000 end-page: 370 ident: bib20 article-title: Protein diversity from alternative splicing: a challenge for bioinformatics and post-genome biology publication-title: Cell – volume: 8 year: 2013 ident: bib33 article-title: Attractor metabolic networks publication-title: PloS One – volume: 104 start-page: 1169 year: 2019 end-page: 1181 ident: bib60 article-title: Geographic variation and bias in the polygenic scores of complex diseases and traits in Finland publication-title: Am. J. Hum. Genet. – volume: 6 start-page: 633 year: 2005 end-page: 642 ident: bib62 article-title: Paternal contribution: new insights and future challenges publication-title: Nat. Rev. Genet. – year: 2007 ident: bib100 article-title: The Nonlinear Universe: Chaos, Emergence and Life – year: 1944 ident: bib99 article-title: What Is Life? – volume: 33 start-page: 337 year: 2018 end-page: 346 ident: bib86 article-title: The missing response to selection in the wild publication-title: Trends Ecol. Evol. – volume: 13 start-page: 160 year: 1988 end-page: 162 ident: bib94 article-title: Reflections on reductionism publication-title: Trends Biochem. Sci. – volume: 8 start-page: 40 year: 1835 end-page: 53 ident: bib22 article-title: An attempt to classify the 'varieties' of animals, with observations on the marked seasonal and other changes which naturally take place in various British species, and which do not constitute varieties publication-title: Magaz. Natural History – volume: 176 start-page: 376 year: 2019 end-page: 387 ident: bib24 article-title: No support for historical candidate gene or candidate gene-by-interaction hypotheses for major depression across multiple large samples publication-title: Am. J. Psychiatr. – volume: 7 start-page: 902 year: 2016 ident: bib7 article-title: On having No head: cognition throughout biological systems publication-title: Front. Psychol. – year: 2014 ident: bib77 article-title: Karl Popper and the Two New Secrets of Life : Including Karl Popper’s Medawar Lecture 1986 and Three Related Texts – volume: 49 start-page: 659 year: 2019 end-page: 677 ident: bib101 article-title: Self-organization in pattern formation publication-title: Dev. Cell – year: 2009 ident: bib25 article-title: Wetware : a Computer in Every Living Cell – volume: 69 start-page: 3351 year: 2012 end-page: 3360 ident: bib58 article-title: What mechanisms/processes underlie radiation-induced genomic instability? publication-title: Cell. Mol. Life Sci. – volume: 718 start-page: 1 year: 2011 end-page: 9 ident: bib16 article-title: Towards a unifying theory of late stochastic effects of ionizing radiation publication-title: Mutat. Res. – volume: 151 start-page: 269 year: 1982 end-page: 273 ident: bib48 article-title: Chromosomal mutation for citrate utilization by Escherichia coli K-12 publication-title: J. Bacteriol. – volume: 12 start-page: 59 year: 2019 end-page: 64 ident: bib14 article-title: Crick's sequence hypothesis: a review publication-title: Commun. Integr. Biol. – volume: 226 start-page: 792 year: 1984 end-page: 801 ident: bib72 article-title: The significance of responses of the genome to challenge publication-title: Science – volume: 159 start-page: 567 year: 2003 end-page: 580 ident: bib75 article-title: Non-targeted and delayed effects of exposure to ionizing radiation: I. Radiation-induced genomic instability and bystander effects in vitro publication-title: Radiat. Res. – volume: 42 start-page: 35 year: 2001 end-page: 44 ident: bib88 article-title: Familial resemblance and heritability publication-title: Adv. Genet. – volume: 533 start-page: 251 year: 2016 end-page: 254 ident: bib35 article-title: Self-organization of the in vitro attached human embryo publication-title: Nature – volume: 4 start-page: 443 year: 1964 end-page: 452 ident: bib36 article-title: Biology, molecular and organismic publication-title: Am. Zool. – volume: 5 start-page: 3 year: 2015 end-page: 11 ident: bib81 article-title: Huygens synchronization of two clocks publication-title: Sci. Rep. – volume: 30 start-page: 1223 year: 2020 end-page: 1234 ident: bib1 article-title: Domain model explains propagation dynamics and stability of histone H3K27 and H3K36 methylation landscapes publication-title: Cell Rep. – volume: 42 start-page: 319 year: 2003 end-page: 329 ident: bib47 article-title: Fisher the evolutionary biologist publication-title: The Statistician – volume: 13 year: 2017 ident: bib63 article-title: What is adaptation by natural selection? Perspectives of an experimental microbiologist publication-title: PLoS Genet. – year: 2015 ident: bib55 article-title: The Trouble with Twin Studies : a Reassessment of Twin Research in the Social and Behavioral Sciences – volume: 150 start-page: 563 year: 1942 end-page: 565 ident: bib110 article-title: Canalisation of development and the inheritance of acquired characters publication-title: Nature – volume: 11 start-page: 446 year: 2010 end-page: 450 ident: bib38 article-title: Missing heritability and strategies for finding the underlying causes of complex disease publication-title: Nat. Rev. Genet. – volume: 149 start-page: 4 year: 2019 end-page: 8 ident: bib15 article-title: Polygenic scores: are they a public health hazard? publication-title: Prog. Biophys. Mol. Biol. – volume: 15 start-page: 212 year: 2020 end-page: 222 ident: bib91 article-title: In the light of the environment: evolution through biogrammars not programmers publication-title: Biol. Theor. – volume: 52 start-page: 399 year: 1918 end-page: 433 ident: bib40 article-title: The correlation between relatives on the supposition of Mendelian Inheritance publication-title: Trans. R. Soc. Edinb. – volume: 5 year: 2016 ident: bib52 article-title: Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994 publication-title: Elife – volume: 590 start-page: 212 year: 2021 end-page: 215 ident: bib43 article-title: A wealth of discovery built on the Human Genome Project - by the numbers publication-title: Nature – volume: 461 start-page: 1243 year: 2009 end-page: 1247 ident: bib10 article-title: Genome evolution and adaptation in a long-term experiment with Escherichia coli publication-title: Nature – volume: 13 start-page: 159 year: 2007 end-page: 187 ident: bib93 article-title: An artificial ecosystem: emergent dynamics and lifelike properties publication-title: Artif. Life – volume: 127 start-page: 123 year: 2007 end-page: 128 ident: bib104 article-title: Natural process--natural selection publication-title: Biophys. Chem. – volume: 12 start-page: 1591 year: 2020 end-page: 1603 ident: bib68 article-title: Divergent evolution of mutation rates and biases in the long-term evolution experiment with Escherichia coli publication-title: Genome Biol. Evol. – year: 1953 ident: bib83 article-title: The Origin of Life – volume: 205 start-page: 1353 year: 2017 end-page: 1364 ident: bib85 article-title: The evolving definition of the term "gene" publication-title: Genetics – volume: 107 start-page: 961 year: 2010 end-page: 968 ident: bib67 article-title: Rate, molecular spectrum, and consequences of human mutation publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 18 start-page: 700 year: 2016 end-page: 708 ident: bib102 article-title: Self-organization of the human embryo in the absence of maternal tissues publication-title: Nat. Cell Biol. – year: 1859 ident: bib31 article-title: On the Origin of Species by Means of Natural Selection, or, the Preservation of Favoured Races in the Struggle for Life – volume: 43 start-page: 281 year: 2013 end-page: 303 ident: bib27 article-title: The ‘missing heritability’ of common disorders: should health researchers care? publication-title: Int. J. Health Serv. – volume: 3 start-page: 258 year: 2008 end-page: 266 ident: bib111 article-title: Paradigm for an evolutionary process publication-title: Biol. Theor. – year: 2017 ident: bib89 article-title: Genes, Brains, and Human Potential : the Science and Ideology of Intelligence – year: 2020 ident: bib4 article-title: Back to Reality – volume: 355 start-page: 738 year: 1992 end-page: 740 ident: bib56 article-title: Transmission of chromosomal instability after plutonium alpha-particle irradiation publication-title: Nature – volume: 106 start-page: 443 year: 2011 end-page: 449 ident: bib13 article-title: A comparison of two cell regulatory models entailing high dimensional attractors representing phenotype publication-title: Prog. Biophys. Mol. Biol. – volume: 3 year: 2008 ident: bib18 article-title: Epigenetic regulation of the mammalian cell publication-title: PloS One – year: 2017 ident: bib79 article-title: Dance to the Tune of Life : Biological Relativity – volume: 7 start-page: 20160135 year: 2017 ident: bib50 article-title: The evolutionary implications of epigenetic inheritance publication-title: Interface Focus – volume: 177 start-page: 393 year: 1972 end-page: 396 ident: bib2 article-title: More is different publication-title: Science – volume: 42 start-page: 849 year: 2018 end-page: 853 ident: bib39 article-title: Fisher's influence on me publication-title: Genet. Epidemiol. – year: 1974 ident: bib65 article-title: The Genetic Basis of Evolutionary Change – volume: 592 start-page: 2261 year: 2014 end-page: 2265 ident: bib17 article-title: The evolutionary origin of form and function publication-title: J. Physiol. – year: 2001 ident: bib71 article-title: What Evolution Is – volume: 461 start-page: 747 year: 2009 end-page: 753 ident: bib70 article-title: Finding the missing heritability of complex diseases publication-title: Nature – year: 1930 ident: bib41 article-title: The Genetical Theory of Natural Selection – year: 2018 ident: bib84 article-title: Blueprint : How DNA Makes Us Who We Are – volume: 119 start-page: 2863 year: 2006 end-page: 2869 ident: bib73 article-title: How can biochemical reactions within cells differ from those in test tubes? publication-title: J. Cell Sci. – volume: 211 start-page: 1125 year: 2019 end-page: 1130 ident: bib109 article-title: From R.A. Fisher's 1918 paper to GWAS a century later publication-title: Genetics – volume: 12 start-page: 138 year: 1958 end-page: 163 ident: bib28 article-title: On protein synthesis publication-title: Symp. Soc. Exp. Biol. – volume: 159 start-page: 581 year: 2003 end-page: 596 ident: bib76 article-title: Non-targeted and delayed effects of exposure to ionizing radiation: II. Radiation-induced genomic instability and bystander effects in vivo, clastogenic factors and transgenerational effects publication-title: Radiat. Res. – start-page: 267 year: 1746 ident: 10.1016/j.pbiomolbio.2021.04.005_bib34 article-title: Les Loix du mouvement et du repos deduites d’un principe metaphysique publication-title: Histoire de l’Acad. Roy. Sci. Belles Lett. – volume: 10 start-page: 1877 issue: 1 year: 2019 ident: 10.1016/j.pbiomolbio.2021.04.005_bib96 article-title: Bacterial chemotaxis in a microfluidic T-maze reveals strong phenotypic heterogeneity in chemotactic sensitivity publication-title: Nat. Commun. doi: 10.1038/s41467-019-09521-2 – volume: 177 start-page: 393 issue: 4047 year: 1972 ident: 10.1016/j.pbiomolbio.2021.04.005_bib2 article-title: More is different publication-title: Science doi: 10.1126/science.177.4047.393 – volume: vol. 1 start-page: 189 year: 1935 ident: 10.1016/j.pbiomolbio.2021.04.005_bib105 – volume: 49 start-page: 659 issue: 5 year: 2019 ident: 10.1016/j.pbiomolbio.2021.04.005_bib101 article-title: Self-organization in pattern formation publication-title: Dev. Cell doi: 10.1016/j.devcel.2019.05.019 – year: 2001 ident: 10.1016/j.pbiomolbio.2021.04.005_bib71 – volume: 752 start-page: 84 issue: 2 year: 2013 ident: 10.1016/j.pbiomolbio.2021.04.005_bib57 article-title: Non-targeted effects of ionising radiation--implications for low dose risk publication-title: Mutat. Res. doi: 10.1016/j.mrrev.2012.12.001 – volume: 12 start-page: 138 year: 1958 ident: 10.1016/j.pbiomolbio.2021.04.005_bib28 article-title: On protein synthesis publication-title: Symp. Soc. Exp. Biol. – year: 1974 ident: 10.1016/j.pbiomolbio.2021.04.005_bib65 – volume: 4 start-page: 216 year: 2013 ident: 10.1016/j.pbiomolbio.2021.04.005_bib45 article-title: Monotonicity is a key feature of genotype-phenotype maps publication-title: Front. Genet. doi: 10.3389/fgene.2013.00216 – volume: 11 start-page: 446 issue: 6 year: 2010 ident: 10.1016/j.pbiomolbio.2021.04.005_bib38 article-title: Missing heritability and strategies for finding the underlying causes of complex disease publication-title: Nat. Rev. Genet. doi: 10.1038/nrg2809 – volume: 211 start-page: 1125 issue: 4 year: 2019 ident: 10.1016/j.pbiomolbio.2021.04.005_bib109 article-title: From R.A. Fisher's 1918 paper to GWAS a century later publication-title: Genetics doi: 10.1534/genetics.118.301594 – volume: 6 start-page: 370 issue: 8 year: 2019 ident: 10.1016/j.pbiomolbio.2021.04.005_bib97 article-title: Bacterial maze runners reveal hidden diversity in chemotactic performance publication-title: Microb. Cell doi: 10.15698/mic2019.08.688 – volume: 30 start-page: 1223 issue: 4 year: 2020 ident: 10.1016/j.pbiomolbio.2021.04.005_bib1 article-title: Domain model explains propagation dynamics and stability of histone H3K27 and H3K36 methylation landscapes publication-title: Cell Rep. doi: 10.1016/j.celrep.2019.12.060 – volume: 461 start-page: 747 issue: 7265 year: 2009 ident: 10.1016/j.pbiomolbio.2021.04.005_bib70 article-title: Finding the missing heritability of complex diseases publication-title: Nature doi: 10.1038/nature08494 – volume: 33 start-page: 337 issue: 5 year: 2018 ident: 10.1016/j.pbiomolbio.2021.04.005_bib86 article-title: The missing response to selection in the wild publication-title: Trends Ecol. Evol. doi: 10.1016/j.tree.2018.02.007 – volume: 149 start-page: 4 year: 2019 ident: 10.1016/j.pbiomolbio.2021.04.005_bib15 article-title: Polygenic scores: are they a public health hazard? publication-title: Prog. Biophys. Mol. Biol. doi: 10.1016/j.pbiomolbio.2019.08.004 – volume: 12 start-page: 441 issue: 9 year: 1990 ident: 10.1016/j.pbiomolbio.2021.04.005_bib78 article-title: Metaphors and the role of genes in development publication-title: Bioessays doi: 10.1002/bies.950120908 – volume: 9 issue: 6 year: 2016 ident: 10.1016/j.pbiomolbio.2021.04.005_bib9 article-title: Understanding of anesthesia - why consciousness is essential for life and not based on genes publication-title: Commun. Integr. Biol. doi: 10.1080/19420889.2016.1238118 – volume: 43 start-page: 281 year: 2013 ident: 10.1016/j.pbiomolbio.2021.04.005_bib27 article-title: The ‘missing heritability’ of common disorders: should health researchers care? publication-title: Int. J. Health Serv. doi: 10.2190/HS.43.2.f – volume: 5 start-page: 11548 3 year: 2015 ident: 10.1016/j.pbiomolbio.2021.04.005_bib81 article-title: Huygens synchronization of two clocks publication-title: Sci. Rep. doi: 10.1038/srep11548 – volume: 533 start-page: 251 issue: 7602 year: 2016 ident: 10.1016/j.pbiomolbio.2021.04.005_bib35 article-title: Self-organization of the in vitro attached human embryo publication-title: Nature doi: 10.1038/nature17948 – volume: 75 start-page: 3907 issue: 21 year: 2018 ident: 10.1016/j.pbiomolbio.2021.04.005_bib42 article-title: Intrinsically disordered proteins in crowded milieu: when chaos prevails within the cellular gumbo publication-title: Cell. Mol. Life Sci. doi: 10.1007/s00018-018-2894-9 – volume: 11 start-page: 20131017 issue: 94 year: 2014 ident: 10.1016/j.pbiomolbio.2021.04.005_bib5 article-title: Genes without prominence: a reappraisal of the foundations of biology publication-title: J. R. Soc. Interface doi: 10.1098/rsif.2013.1017 – year: 2018 ident: 10.1016/j.pbiomolbio.2021.04.005_bib84 – volume: 42 start-page: 849 issue: 8 year: 2018 ident: 10.1016/j.pbiomolbio.2021.04.005_bib39 article-title: Fisher's influence on me publication-title: Genet. Epidemiol. doi: 10.1002/gepi.22165 – year: 2014 ident: 10.1016/j.pbiomolbio.2021.04.005_bib77 – volume: 364 start-page: 948 issue: 6444 year: 2019 ident: 10.1016/j.pbiomolbio.2021.04.005_bib103 article-title: Self-organization of stem cells into embryos: a window on early mammalian development publication-title: Science doi: 10.1126/science.aax0164 – volume: 104 start-page: 1169 issue: 6 year: 2019 ident: 10.1016/j.pbiomolbio.2021.04.005_bib60 article-title: Geographic variation and bias in the polygenic scores of complex diseases and traits in Finland publication-title: Am. J. Hum. Genet. doi: 10.1016/j.ajhg.2019.05.001 – volume: 51 start-page: 513 year: 1917 ident: 10.1016/j.pbiomolbio.2021.04.005_bib74 article-title: The theory of the gene publication-title: Am. Nat. doi: 10.1086/279629 – volume: 13 issue: 4 year: 2017 ident: 10.1016/j.pbiomolbio.2021.04.005_bib63 article-title: What is adaptation by natural selection? Perspectives of an experimental microbiologist publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1006668 – volume: 45 start-page: 284 issue: 4 year: 2020 ident: 10.1016/j.pbiomolbio.2021.04.005_bib30 article-title: Learning of signaling networks: molecular mechanisms publication-title: Trends Biochem. Sci. doi: 10.1016/j.tibs.2019.12.005 – volume: 43 start-page: 1007 issue: 4 year: 2014 ident: 10.1016/j.pbiomolbio.2021.04.005_bib92 article-title: Commentary: Wilhelm Johannsen and the problem of heredity at the turn of the 19th century publication-title: Int. J. Epidemiol. doi: 10.1093/ije/dyu066 – volume: 198 start-page: 1022 issue: 7 year: 2016 ident: 10.1016/j.pbiomolbio.2021.04.005_bib107 article-title: Rapid evolution of citrate utilization by Escherichia coli by direct selection requires citT and dctA publication-title: J. Bacteriol. doi: 10.1128/JB.00831-15 – volume: 355 start-page: 738 issue: 6362 year: 1992 ident: 10.1016/j.pbiomolbio.2021.04.005_bib56 article-title: Transmission of chromosomal instability after plutonium alpha-particle irradiation publication-title: Nature doi: 10.1038/355738a0 – volume: 69 start-page: 3351 issue: 20 year: 2012 ident: 10.1016/j.pbiomolbio.2021.04.005_bib58 article-title: What mechanisms/processes underlie radiation-induced genomic instability? publication-title: Cell. Mol. Life Sci. doi: 10.1007/s00018-012-1148-5 – volume: 227 start-page: 561 issue: 5258 year: 1970 ident: 10.1016/j.pbiomolbio.2021.04.005_bib29 article-title: Central dogma of molecular biology publication-title: Nature doi: 10.1038/227561a0 – year: 1944 ident: 10.1016/j.pbiomolbio.2021.04.005_bib99 – volume: 52 start-page: 153 issue: 1–2 year: 1990 ident: 10.1016/j.pbiomolbio.2021.04.005_bib106 article-title: The chemical basis of morphogenesis publication-title: Bull. Math. Biol. doi: 10.1016/S0092-8240(05)80008-4 – volume: 47 start-page: 1309 year: 1961 ident: 10.1016/j.pbiomolbio.2021.04.005_bib3 article-title: The kinetics of formation of native ribonuclease during oxidation of the reduced polypeptide chain publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.47.9.1309 – volume: 91 start-page: 6808 issue: 15 year: 1994 ident: 10.1016/j.pbiomolbio.2021.04.005_bib64 article-title: Dynamics of adaptation and diversification: a 10,000-generation experiment with bacterial populations publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.91.15.6808 – volume: 42 start-page: 35 year: 2001 ident: 10.1016/j.pbiomolbio.2021.04.005_bib88 article-title: Familial resemblance and heritability publication-title: Adv. Genet. doi: 10.1016/S0065-2660(01)42013-X – year: 1969 ident: 10.1016/j.pbiomolbio.2021.04.005_bib19 – volume: 151 start-page: 269 issue: 1 year: 1982 ident: 10.1016/j.pbiomolbio.2021.04.005_bib48 article-title: Chromosomal mutation for citrate utilization by Escherichia coli K-12 publication-title: J. Bacteriol. doi: 10.1128/jb.151.1.269-273.1982 – year: 1953 ident: 10.1016/j.pbiomolbio.2021.04.005_bib83 – year: 2009 ident: 10.1016/j.pbiomolbio.2021.04.005_bib32 – volume: 7 start-page: 477 issue: 4 year: 2010 ident: 10.1016/j.pbiomolbio.2021.04.005_bib69 article-title: Natural patterns of energy dispersal publication-title: Phys. Life Rev. doi: 10.1016/j.plrev.2010.10.001 – volume: 176 start-page: 376 issue: 5 year: 2019 ident: 10.1016/j.pbiomolbio.2021.04.005_bib24 article-title: No support for historical candidate gene or candidate gene-by-interaction hypotheses for major depression across multiple large samples publication-title: Am. J. Psychiatr. doi: 10.1176/appi.ajp.2018.18070881 – volume: 144 start-page: 850 issue: 6 year: 2011 ident: 10.1016/j.pbiomolbio.2021.04.005_bib80 article-title: The cell in an era of systems biology publication-title: Cell doi: 10.1016/j.cell.2011.02.045 – volume: 38 start-page: 664 issue: 7 year: 2016 ident: 10.1016/j.pbiomolbio.2021.04.005_bib21 article-title: Missing heritability of complex diseases: enlightenment by genetic variants from intermediate phenotypes publication-title: Bioessays doi: 10.1002/bies.201600084 – volume: 5 year: 2016 ident: 10.1016/j.pbiomolbio.2021.04.005_bib52 article-title: Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994 publication-title: Elife doi: 10.7554/eLife.20320 – volume: 6 start-page: 633 issue: 8 year: 2005 ident: 10.1016/j.pbiomolbio.2021.04.005_bib62 article-title: Paternal contribution: new insights and future challenges publication-title: Nat. Rev. Genet. doi: 10.1038/nrg1654 – volume: 590 start-page: 212 issue: 7845 year: 2021 ident: 10.1016/j.pbiomolbio.2021.04.005_bib43 article-title: A wealth of discovery built on the Human Genome Project - by the numbers publication-title: Nature doi: 10.1038/d41586-021-00314-6 – volume: 205 start-page: 1353 issue: 4 year: 2017 ident: 10.1016/j.pbiomolbio.2021.04.005_bib85 article-title: The evolving definition of the term "gene" publication-title: Genetics doi: 10.1534/genetics.116.196956 – volume: 260 start-page: 340 issue: 5 year: 1999 ident: 10.1016/j.pbiomolbio.2021.04.005_bib113 article-title: Concepts of synchronization in dynamical systems publication-title: Phys. Lett. doi: 10.1016/S0375-9601(99)00532-0 – volume: 12 start-page: 59 issue: 1 year: 2019 ident: 10.1016/j.pbiomolbio.2021.04.005_bib14 article-title: Crick's sequence hypothesis: a review publication-title: Commun. Integr. Biol. doi: 10.1080/19420889.2019.1594501 – volume: 3 issue: 6 year: 2008 ident: 10.1016/j.pbiomolbio.2021.04.005_bib18 article-title: Epigenetic regulation of the mammalian cell publication-title: PloS One doi: 10.1371/journal.pone.0002290 – volume: 293 start-page: 1089 issue: 5532 year: 2001 ident: 10.1016/j.pbiomolbio.2021.04.005_bib87 article-title: Epigenetic reprogramming in mammalian development publication-title: Science doi: 10.1126/science.1063443 – volume: 15 start-page: 212 year: 2020 ident: 10.1016/j.pbiomolbio.2021.04.005_bib91 article-title: In the light of the environment: evolution through biogrammars not programmers publication-title: Biol. Theor. doi: 10.1007/s13752-020-00356-5 – year: 1974 ident: 10.1016/j.pbiomolbio.2021.04.005_bib23 – volume: 226 start-page: 792 issue: 4676 year: 1984 ident: 10.1016/j.pbiomolbio.2021.04.005_bib72 article-title: The significance of responses of the genome to challenge publication-title: Science doi: 10.1126/science.15739260 – volume: 718 start-page: 1 issue: 1–2 year: 2011 ident: 10.1016/j.pbiomolbio.2021.04.005_bib16 article-title: Towards a unifying theory of late stochastic effects of ionizing radiation publication-title: Mutat. Res. – volume: 7 start-page: 20160135 issue: 5 year: 2017 ident: 10.1016/j.pbiomolbio.2021.04.005_bib50 article-title: The evolutionary implications of epigenetic inheritance publication-title: Interface Focus doi: 10.1098/rsfs.2016.0135 – volume: 9 issue: 4 year: 2016 ident: 10.1016/j.pbiomolbio.2021.04.005_bib6 article-title: Discourse on order vs. disorder publication-title: Commun. Integr. Biol. doi: 10.1080/19420889.2016.1187348 – volume: 119 start-page: 2863 issue: Pt 14 year: 2006 ident: 10.1016/j.pbiomolbio.2021.04.005_bib73 article-title: How can biochemical reactions within cells differ from those in test tubes? publication-title: J. Cell Sci. doi: 10.1242/jcs.03063 – volume: 748 start-page: 36 issue: 1 - 2 year: 2012 ident: 10.1016/j.pbiomolbio.2021.04.005_bib49 article-title: Radiation-induced genomic instability in Caenorhabditis elegans publication-title: Mutat. Res. doi: 10.1016/j.mrgentox.2012.06.010 – volume: 12 start-page: 18 issue: 3 year: 2010 ident: 10.1016/j.pbiomolbio.2021.04.005_bib66 article-title: Robert Rosen's anticipatory systems publication-title: Foresight doi: 10.1108/14636681011049848 – volume: 150 start-page: 563 year: 1942 ident: 10.1016/j.pbiomolbio.2021.04.005_bib110 article-title: Canalisation of development and the inheritance of acquired characters publication-title: Nature doi: 10.1038/150563a0 – year: 2020 ident: 10.1016/j.pbiomolbio.2021.04.005_bib4 – volume: 3 start-page: 318 issue: 3 year: 1961 ident: 10.1016/j.pbiomolbio.2021.04.005_bib51 article-title: Genetic regulatory mechanisms in the synthesis of proteins publication-title: J. Mol. Biol. doi: 10.1016/S0022-2836(61)80072-7 – volume: 7 start-page: 902 year: 2016 ident: 10.1016/j.pbiomolbio.2021.04.005_bib7 article-title: On having No head: cognition throughout biological systems publication-title: Front. Psychol. doi: 10.3389/fpsyg.2016.00902 – volume: 107 start-page: 961 issue: 3 year: 2010 ident: 10.1016/j.pbiomolbio.2021.04.005_bib67 article-title: Rate, molecular spectrum, and consequences of human mutation publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.0912629107 – year: 1930 ident: 10.1016/j.pbiomolbio.2021.04.005_bib41 – volume: 48 start-page: 10 issue: 1 year: 2019 ident: 10.1016/j.pbiomolbio.2021.04.005_bib108 article-title: Commentary: Fisher 1918: the foundation of the genetics and analysis of complex traits publication-title: Int. J. Epidemiol. doi: 10.1093/ije/dyx129 – year: 2009 ident: 10.1016/j.pbiomolbio.2021.04.005_bib25 – volume: 125 start-page: 11 issue: 1 year: 2020 ident: 10.1016/j.pbiomolbio.2021.04.005_bib26 article-title: Plants are intelligent, here's how publication-title: Ann. Bot. doi: 10.1093/aob/mcz155 – year: 2017 ident: 10.1016/j.pbiomolbio.2021.04.005_bib79 – volume: 159 start-page: 581 issue: 5 year: 2003 ident: 10.1016/j.pbiomolbio.2021.04.005_bib76 article-title: Non-targeted and delayed effects of exposure to ionizing radiation: II. Radiation-induced genomic instability and bystander effects in vivo, clastogenic factors and transgenerational effects publication-title: Radiat. Res. doi: 10.1667/0033-7587(2003)159[0581:NADEOE]2.0.CO;2 – volume: 3 start-page: 258 issue: 3 year: 2008 ident: 10.1016/j.pbiomolbio.2021.04.005_bib111 article-title: Paradigm for an evolutionary process publication-title: Biol. Theor. doi: 10.1162/biot.2008.3.3.258 – volume: 8 issue: 3 year: 2013 ident: 10.1016/j.pbiomolbio.2021.04.005_bib33 article-title: Attractor metabolic networks publication-title: PloS One doi: 10.1371/journal.pone.0058284 – volume: 7 start-page: 3459 issue: 10 year: 2017 ident: 10.1016/j.pbiomolbio.2021.04.005_bib59 article-title: Fine-scale genetic structure in Finland publication-title: G3 (Bethesda) doi: 10.1534/g3.117.300217 – volume: 106 start-page: 443 issue: 2 year: 2011 ident: 10.1016/j.pbiomolbio.2021.04.005_bib13 article-title: A comparison of two cell regulatory models entailing high dimensional attractors representing phenotype publication-title: Prog. Biophys. Mol. Biol. doi: 10.1016/j.pbiomolbio.2011.01.002 – volume: 2 start-page: 60 issue: 1 year: 2009 ident: 10.1016/j.pbiomolbio.2021.04.005_bib8 article-title: Deep evolutionary origins of neurobiology: turning the essence of 'neural' upside-down publication-title: Commun. Integr. Biol. doi: 10.4161/cib.2.1.7620 – year: 2007 ident: 10.1016/j.pbiomolbio.2021.04.005_bib100 – volume: 929 start-page: 41 year: 2001 ident: 10.1016/j.pbiomolbio.2021.04.005_bib44 article-title: Consciousness, reduction, and emergence. Some remarks publication-title: Ann. N. Y. Acad. Sci. doi: 10.1111/j.1749-6632.2001.tb05705.x – volume: 111 start-page: 75 issue: 2–3 year: 2013 ident: 10.1016/j.pbiomolbio.2021.04.005_bib82 article-title: From sequence to consequence and back publication-title: Prog. Biophys. Mol. Biol. doi: 10.1016/j.pbiomolbio.2012.09.003 – year: 2017 ident: 10.1016/j.pbiomolbio.2021.04.005_bib89 – volume: 13 start-page: 160 issue: 5 year: 1988 ident: 10.1016/j.pbiomolbio.2021.04.005_bib94 article-title: Reflections on reductionism publication-title: Trends Biochem. Sci. doi: 10.1016/0968-0004(88)90138-7 – volume: 454 start-page: 89 issue: 1–2 year: 2000 ident: 10.1016/j.pbiomolbio.2021.04.005_bib12 article-title: Radiation-induced genomic instability: a paradigm-breaking phenomenon and its relevance to environmentally induced cancer publication-title: Mutat. Res. doi: 10.1016/S0027-5107(00)00100-7 – year: 1991 ident: 10.1016/j.pbiomolbio.2021.04.005_bib95 – volume: 76 start-page: 1589 issue: 7 year: 2018 ident: 10.1016/j.pbiomolbio.2021.04.005_bib11 article-title: The fundamental theorem of natural selection with mutations publication-title: J. Math. Biol. doi: 10.1007/s00285-017-1190-x – volume: 127 start-page: 123 issue: 1–2 year: 2007 ident: 10.1016/j.pbiomolbio.2021.04.005_bib104 article-title: Natural process--natural selection publication-title: Biophys. Chem. doi: 10.1016/j.bpc.2007.01.005 – volume: 461 start-page: 1243 issue: 7268 year: 2009 ident: 10.1016/j.pbiomolbio.2021.04.005_bib10 article-title: Genome evolution and adaptation in a long-term experiment with Escherichia coli publication-title: Nature doi: 10.1038/nature08480 – year: 1999 ident: 10.1016/j.pbiomolbio.2021.04.005_bib37 – volume: 12 start-page: 1591 issue: 9 year: 2020 ident: 10.1016/j.pbiomolbio.2021.04.005_bib68 article-title: Divergent evolution of mutation rates and biases in the long-term evolution experiment with Escherichia coli publication-title: Genome Biol. Evol. doi: 10.1093/gbe/evaa178 – year: 2021 ident: 10.1016/j.pbiomolbio.2021.04.005_bib98 article-title: The use of negative control outcomes in Mendelian randomization to detect potential population stratification publication-title: Int. J. Epidemiol. doi: 10.1093/ije/dyaa288 – year: 1859 ident: 10.1016/j.pbiomolbio.2021.04.005_bib31 – volume: 592 start-page: 2261 issue: 11 year: 2014 ident: 10.1016/j.pbiomolbio.2021.04.005_bib17 article-title: The evolutionary origin of form and function publication-title: J. Physiol. doi: 10.1113/jphysiol.2014.271775 – volume: 2 start-page: 196 issue: 3 year: 1998 ident: 10.1016/j.pbiomolbio.2021.04.005_bib61 article-title: HARKing: hypothesizing after the results are known publication-title: Pers. Soc. Psychol. Rev. doi: 10.1207/s15327957pspr0203_4 – volume: 55 start-page: 35 year: 2019 ident: 10.1016/j.pbiomolbio.2021.04.005_bib90 article-title: Why genome-wide associations with cognitive ability measures are probably spurious publication-title: New Ideas Psychol. doi: 10.1016/j.newideapsych.2019.04.005 – volume: 52 start-page: 399 year: 1918 ident: 10.1016/j.pbiomolbio.2021.04.005_bib40 article-title: The correlation between relatives on the supposition of Mendelian Inheritance publication-title: Trans. R. Soc. Edinb. doi: 10.1017/S0080456800012163 – volume: 18 start-page: 700 issue: 6 year: 2016 ident: 10.1016/j.pbiomolbio.2021.04.005_bib102 article-title: Self-organization of the human embryo in the absence of maternal tissues publication-title: Nat. Cell Biol. doi: 10.1038/ncb3347 – volume: 103 start-page: 367 issue: 3 year: 2000 ident: 10.1016/j.pbiomolbio.2021.04.005_bib20 article-title: Protein diversity from alternative splicing: a challenge for bioinformatics and post-genome biology publication-title: Cell doi: 10.1016/S0092-8674(00)00128-8 – volume: 13 start-page: 159 issue: 2 year: 2007 ident: 10.1016/j.pbiomolbio.2021.04.005_bib93 article-title: An artificial ecosystem: emergent dynamics and lifelike properties publication-title: Artif. Life doi: 10.1162/artl.2007.13.2.159 – volume: 551 start-page: 45 issue: 7678 year: 2017 ident: 10.1016/j.pbiomolbio.2021.04.005_bib46 article-title: The dynamics of molecular evolution over 60,000 generations publication-title: Nature doi: 10.1038/nature24287 – volume: 4 start-page: 443 year: 1964 ident: 10.1016/j.pbiomolbio.2021.04.005_bib36 article-title: Biology, molecular and organismic publication-title: Am. Zool. doi: 10.1093/icb/4.4.443 – volume: 159 start-page: 567 issue: 5 year: 2003 ident: 10.1016/j.pbiomolbio.2021.04.005_bib75 article-title: Non-targeted and delayed effects of exposure to ionizing radiation: I. Radiation-induced genomic instability and bystander effects in vitro publication-title: Radiat. Res. doi: 10.1667/0033-7587(2003)159[0567:NADEOE]2.0.CO;2 – volume: 42 start-page: 319 issue: 3 year: 2003 ident: 10.1016/j.pbiomolbio.2021.04.005_bib47 article-title: Fisher the evolutionary biologist publication-title: The Statistician doi: 10.1111/1467-9884.00362 – volume: 8 start-page: 40 year: 1835 ident: 10.1016/j.pbiomolbio.2021.04.005_bib22 article-title: An attempt to classify the 'varieties' of animals, with observations on the marked seasonal and other changes which naturally take place in various British species, and which do not constitute varieties publication-title: Magaz. Natural History – volume: 342 start-page: 1364 issue: 6164 year: 2013 ident: 10.1016/j.pbiomolbio.2021.04.005_bib112 article-title: Long-term dynamics of adaptation in asexual populations publication-title: Science doi: 10.1126/science.1243357 – volume: 45 start-page: 129 year: 1911 ident: 10.1016/j.pbiomolbio.2021.04.005_bib53 article-title: The genotype cconception of heredity publication-title: Am. Nat. doi: 10.1086/279202 – year: 2015 ident: 10.1016/j.pbiomolbio.2021.04.005_bib55 |
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