Hyaline Cartilage Microtissues Engineered from Adult Dedifferentiated Chondrocytes: Safety and Role of WNT Signaling

• Published in: Stem cells translational medicine Vol. 11; no. 12; pp. 1219 - 1231
• Main Authors: Kutaish, Halah, Bengtsson, Laura, Matthias Tscholl, Philippe, Marteyn, Antoine, Braunersreuther, Vincent, Guérin, Alexandre, Béna, Frédérique, Gimelli, Stefania, Longet, David, Ilmjärv, Sten, Dietrich, Pierre-Yves, Gerstel, Eric, Jaquet, Vincent, Hannouche, Didier, Menetrey, Jacques, Assal, Mathieu, Krause, Karl-Heinz, Cosset, Erika, Tieng, Vannary
• Format: Journal Article
• Language: English
• Published: England Wiley 30.12.2022; Oxford University Press
• Subjects: Animals; Cartilage, Articular; Cells, Cultured; Chondrocytes - metabolism; Hyaline Cartilage - metabolism; Life Sciences; Mice; Mice, SCID; Tissue Engineering - methods; Tissue Engineering and Regenerative Medicine; Wnt Signaling Pathway; articular cartilage; tissue engineering; microtissues; dedifferentiation; WNT signaling; re-differentiation; hyaline cartilage

The repair of damaged articular cartilage is an unmet medical need. Chondrocyte-based cell therapy has been used to repair cartilage for over 20 years despite current limitations. Chondrocyte dedifferentiation upon expansion in monolayer is well known and is the main obstacle to their use as cell so...