Post-exposure antioxidant treatment in rats decreases airway hyperplasia and hyperreactivity due to chlorine inhalation

• Published in: American journal of respiratory cell and molecular biology Vol. 46; no. 5; pp. 599 - 606
• Main Authors: Fanucchi, Michelle V, Bracher, Andreas, Doran, Stephen F, Squadrito, Giuseppe L, Fernandez, Solana, Postlethwait, Edward M, Bowen, Larry, Matalon, Sadis
• Format: Journal Article
• Language: English
• Published: United States American Thoracic Society 01.05.2012
• Subjects: Animals; Antioxidants - pharmacology; Antioxidants - therapeutic use; Ascorbic Acid - metabolism; Bronchi - drug effects; Bronchi - pathology; Bronchial Provocation Tests; Chlorine - administration & dosage; Chlorine - toxicity; Glutathione - metabolism; Hyperplasia - prevention & control; Inhalation Exposure; Lung - pathology; Male; Rats; Rats, Sprague-Dawley; Trachea - drug effects; Trachea - pathology

We assessed the safety and efficacy of combined intravenous and aerosolized antioxidant administration to attenuate chlorine gas-induced airway alterations when administered after exposure. Adult male Sprague-Dawley rats were exposed to air or 400 parts per million (ppm) chlorine (a concentration li...