Splice variants of protein disulfide isomerase - identification, distribution and functional characterization in the rat

• Published in: Biochimica et biophysica acta. General subjects Vol. 1867; no. 2; p. 130280
• Main Authors: Chetot, Thomas, Serfaty, Xavier, Carret, Léna, Kriznik, Alexandre, Sophie-Rahuel-Clermont, Grand, Lucie, Jacolot, Maïwenn, Popowycz, Florence, Benoit, Etienne, Lambert, Véronique, Lattard, Virginie
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.02.2023; Elsevier
• Subjects: Animals; Biochemistry, Molecular Biology; Chemical Sciences; consensus sequence; Electron transfer; hematology; Life Sciences; liver; Liver - metabolism; Male; oxidoreductases; Oxidoreductases - metabolism; Protein disulfide isomerase (PDI); protein disulfide-isomerase; Protein Disulfide-Isomerases - genetics; Protein Disulfide-Isomerases - metabolism; Protein Sorting Signals; Protein variant; Rats; RNA, Messenger - metabolism; signal peptide; Splice variant; therapeutics; Protein variant; Electron transfer; Protein disulfide isomerase (PDI); Splice variant

Protein Disulfide Isomerase (PDI) enzyme is an emerging therapeutic target in oncology and hematology. Although PDI reductase activity has been studied with isolated fragments of the protein, natural structural variations affecting reductase activity have not been addressed. In this study, we discov...