Monocyte Adhesion, Migration, and Extracellular Matrix Breakdown Are Regulated by Integrin αVβ3 in Mycobacterium tuberculosis Infection

• Published in: The Journal of immunology (1950) Vol. 199; no. 3; pp. 982 - 991
• Main Authors: Brilha, Sara, Wysoczanski, Riccardo, Whittington, Ashley M, Friedland, Jon S, Porter, Joanna C
• Format: Journal Article
• Language: English
• Published: England American Association of Immunologists 01.08.2017; AAI
• Subjects: Cavitation; Cell Adhesion; Cell adhesion & migration; Cell Movement; Collagen; Collagen (type I); Collagen Type I - metabolism; Collagenase; Collagenases - metabolism; Extracellular matrix; Extracellular Matrix - drug effects; Extracellular Matrix - metabolism; Fibronectin; Fibronectins - metabolism; Gene expression; Gene Expression Regulation; Humans; Immune response; Infectious Disease and Host Response; Inflammation; Integrin alphaVbeta3 - antagonists & inhibitors; Integrin alphaVbeta3 - genetics; Integrin alphaVbeta3 - immunology; Interstitial collagenase; Leukocyte migration; Matrilysin; Matrix metalloproteinase; Matrix Metalloproteinase 1 - genetics; Matrix Metalloproteinase 1 - metabolism; Matrix Metalloproteinase 10 - immunology; Matrix Metalloproteinase 10 - metabolism; Matrix Metalloproteinase 7 - immunology; Matrix Metalloproteinase 7 - metabolism; Matrix Metalloproteinase Inhibitors - pharmacology; Monocytes; Monocytes - immunology; Monocytes - microbiology; Monocytes - physiology; Morbidity; Mycobacterium tuberculosis; Mycobacterium tuberculosis - immunology; Signal Transduction; Sputum; Sputum - chemistry; Stromelysin 2; Tissue inhibitor of metalloproteinase 1; Tuberculosis; Up-Regulation

In tuberculosis (TB), the innate inflammatory immune response drives tissue destruction, morbidity, and mortality. Monocytes secrete matrix metalloproteinases (MMPs), which have key roles in local tissue destruction and cavitation. We hypothesized that integrin signaling might regulate monocyte MMP...