Sex-stratified differences in early antithrombotic treatment response in patients presenting with ST-segment elevation myocardial infarction

• Published in: The American heart journal Vol. 258; pp. 17 - 26
• Main Authors: Delewi, Ronak, Vogel, Rosanne F., Wilschut, Jeroen M., Lemmert, Miguel E., Diletti, Roberto, van Vliet, Ria, van der Waarden, Nancy W.P.L., Nuis, Rutger-Jan, Paradies, Valeria, Alexopoulos, Dimitrios, Zijlstra, Felix, Montalescot, Gilles, Angiolillo, Dominick J., Krucoff, Mitchell W., Doevendans, Pieter A., Van Mieghem, Nicolas M., Smits, Pieter C., Vlachojannis, Georgios J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2023; Elsevier Limited
• Subjects: Anticoagulants; Antiplatelet therapy; Bleeding; Blood platelets; Cardiovascular disease; Clinical outcomes; Complications; Coronary vessels; Female; Females; Fibrinolytic Agents - therapeutic use; Gender differences; Glycoproteins; Heart attacks; Hemorrhage - chemically induced; Hemorrhage - epidemiology; Hospitals; Humans; Male; Males; Medical imaging; Myocardial infarction; Patients; Percutaneous Coronary Intervention - adverse effects; Pharmacodynamics; Platelet Aggregation Inhibitors - adverse effects; Platelets; Prasugrel Hydrochloride - therapeutic use; Reactivity; Regression analysis; Segments; Sex; Sex differences; Sexes; ST Elevation Myocardial Infarction - therapy; Treatment Outcome; Spain

The mechanisms underlying the increased risk of bleeding that female patients with ST-segment Elevation Myocardial Infarction (STEMI) exhibit, remains unclear. The present report assessed sex-related differences in response to pre-hospital dual antiplatelet therapy (DAPT) initiation in patients with...