fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation
Experiments in amphibians have implicated fibroblast growth factors (FGFs) in the generation and patterning of mesoderm during embryogenesis. We have mutated the gene for fibroblast growth factor receptor 1 (fgfr-1) in the mouse to genetically dissect the role of FGF signaling during development. In...
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| Published in | Genes & development Vol. 8; no. 24; pp. 3032 - 3044 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
15.12.1994
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Experiments in amphibians have implicated fibroblast growth factors (FGFs) in the generation and patterning of mesoderm during embryogenesis. We have mutated the gene for fibroblast growth factor receptor 1 (fgfr-1) in the mouse to genetically dissect the role of FGF signaling during development. In the absence of fgfr-1 signaling, embryos displayed early growth defects; however, they remained capable of gastrulating and generating mesoderm. The nascent mesoderm of fgfr-1 homozygous mutant embryos differentiated into diverse mesodermal subtypes, but mesodermal patterning was aberrant. Somites were never generated and axial mesoderm was greatly expanded at the expense of paraxial mesoderm. These results suggest that FGFR-1 transduces signals that specify mesodermal cell fates and regional patterning of the mesoderm during gastrulation. |
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| AbstractList | Experiments in amphibians have implicated fibroblast growth factors (FGFs) in the generation and patterning of mesoderm during embryogenesis. We have mutated the gene for fibroblast growth factor receptor 1 (fgfr-1) in the mouse to genetically dissect the role of FGF signaling during development. In the absence of fgfr-1 signaling, embryos displayed early growth defects; however, they remained capable of gastrulating and generating mesoderm. The nascent mesoderm of fgfr-1 homozygous mutant embryos differentiated into diverse mesodermal subtypes, but mesodermal patterning was aberrant. Somites were never generated and axial mesoderm was greatly expanded at the expense of paraxial mesoderm. These results suggest that FGFR-1 transduces signals that specify mesodermal cell fates and regional patterning of the mesoderm during gastrulation. Experiments in amphibians have implicated fibroblast growth factors (FGFs) in the generation and patterning of mesoderm during embryogenesis. We have mutated the gene for fibroblast growth factor receptor 1 (fgfr-1) in the mouse to genetically dissect the role of FGF signaling during development. In the absence of fgfr-1 signaling, embryos displayed early growth defects; however, they remained capable of gastrulating and generating mesoderm. The nascent mesoderm of fgfr-1 homozygous mutant embryos differentiated into diverse mesodermal subtypes, but mesodermal patterning was aberrant. Somites were never generated and axial mesoderm was greatly expanded at the expense of paraxial mesoderm. The results suggest that FGFR-1 transduces signals that specify mesodermal cell fates and regional patterning of the mesoderm during gastrulation. |
| Author | Yamaguchi, T P Harpal, K Rossant, J Henkemeyer, M |
| Author_xml | – sequence: 1 givenname: T P surname: Yamaguchi fullname: Yamaguchi, T P organization: Samuel Lunenfeld Research Institute (SLRI), Mount Sinai Hospital, Toronto, Ontario, Canada – sequence: 2 givenname: K surname: Harpal fullname: Harpal, K – sequence: 3 givenname: M surname: Henkemeyer fullname: Henkemeyer, M – sequence: 4 givenname: J surname: Rossant fullname: Rossant, J |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/8001822$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | Animals Base Sequence Cloning, Molecular Crosses, Genetic DNA Primers Embryonic and Fetal Development Exons Female Fetal Death Fibroblast Growth Factors - physiology Gastrula - physiology Genes, Lethal Genetic Markers Genotype Heterozygote Kanamycin Kinase Male Mesoderm - physiology Mice Mice, Inbred C57BL Mice, Inbred Strains Mice, Transgenic Molecular Sequence Data Phosphotransferases (Alcohol Group Acceptor) - analysis Phosphotransferases (Alcohol Group Acceptor) - biosynthesis Polymerase Chain Reaction Pregnancy Receptor Protein-Tyrosine Kinases Receptor, Fibroblast Growth Factor, Type 1 Receptors, Fibroblast Growth Factor - biosynthesis Receptors, Fibroblast Growth Factor - genetics Receptors, Fibroblast Growth Factor - physiology Restriction Mapping Signal Transduction |
| Title | fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation |
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