Aryl Hydrocarbon Receptor Mediates Larval Zebrafish Fin Duplication Following Exposure to Benzofluoranthenes
Abstract The aryl hydrocarbon receptor (AHR) mediates developmental toxicity of several xenobiotic classes including polycyclic aromatic hydrocarbons. Using embryonic zebrafish, we previously identified 4 polycyclic aromatic hydrocarbons that caused a novel phenotype among AHR ligands—growth of a la...
Saved in:
Published in | Toxicological sciences Vol. 176; no. 1; pp. 46 - 64 |
---|---|
Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Oxford University Press
01.07.2020
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Abstract
The aryl hydrocarbon receptor (AHR) mediates developmental toxicity of several xenobiotic classes including polycyclic aromatic hydrocarbons. Using embryonic zebrafish, we previously identified 4 polycyclic aromatic hydrocarbons that caused a novel phenotype among AHR ligands—growth of a lateral, duplicate caudal fin fold. The window of sensitivity to the most potent inducer of this phenotype, benzo[k]fluoranthene (BkF), was prior to 36 h postfertilization (hpf), although the phenotype was not manifest until 60 hpf. AHR dependency via Ahr2 was demonstrated using morpholino knockdown. Hepatocyte ablation demonstrated that hepatic metabolism of BkF was not required for the phenotype, nor was it responsible for the window of sensitivity. RNA sequencing performed on caudal trunk tissue from BkF-exposed animals collected at 48, 60, 72, and 96 hpf showed upregulation of genes associated with AHR activation, appendage development, and tissue patterning. Genes encoding fibroblast growth factor and bone morphogenic protein ligands, along with retinaldehyde dehydrogenase, were prominently upregulated. Gene Ontology term analysis revealed that upregulated genes were enriched for mesoderm development and fin regeneration, whereas downregulated genes were enriched for Wnt signaling and neuronal development. MetaCore (Clarivate Analytics) systems analysis of orthologous human genes predicted that R-SMADs, AP-1, and LEF1 regulated the expression of an enriched number of gene targets across all time points. Our results demonstrate a novel aspect of AHR activity with implications for developmental processes conserved across vertebrate species. |
---|---|
AbstractList | Abstract
The aryl hydrocarbon receptor (AHR) mediates developmental toxicity of several xenobiotic classes including polycyclic aromatic hydrocarbons. Using embryonic zebrafish, we previously identified 4 polycyclic aromatic hydrocarbons that caused a novel phenotype among AHR ligands—growth of a lateral, duplicate caudal fin fold. The window of sensitivity to the most potent inducer of this phenotype, benzo[k]fluoranthene (BkF), was prior to 36 h postfertilization (hpf), although the phenotype was not manifest until 60 hpf. AHR dependency via Ahr2 was demonstrated using morpholino knockdown. Hepatocyte ablation demonstrated that hepatic metabolism of BkF was not required for the phenotype, nor was it responsible for the window of sensitivity. RNA sequencing performed on caudal trunk tissue from BkF-exposed animals collected at 48, 60, 72, and 96 hpf showed upregulation of genes associated with AHR activation, appendage development, and tissue patterning. Genes encoding fibroblast growth factor and bone morphogenic protein ligands, along with retinaldehyde dehydrogenase, were prominently upregulated. Gene Ontology term analysis revealed that upregulated genes were enriched for mesoderm development and fin regeneration, whereas downregulated genes were enriched for Wnt signaling and neuronal development. MetaCore (Clarivate Analytics) systems analysis of orthologous human genes predicted that R-SMADs, AP-1, and LEF1 regulated the expression of an enriched number of gene targets across all time points. Our results demonstrate a novel aspect of AHR activity with implications for developmental processes conserved across vertebrate species. The aryl hydrocarbon receptor (AHR) mediates developmental toxicity of several xenobiotic classes including polycyclic aromatic hydrocarbons. Using embryonic zebrafish, we previously identified 4 polycyclic aromatic hydrocarbons that caused a novel phenotype among AHR ligands-growth of a lateral, duplicate caudal fin fold. The window of sensitivity to the most potent inducer of this phenotype, benzo[k]fluoranthene (BkF), was prior to 36 h postfertilization (hpf), although the phenotype was not manifest until 60 hpf. AHR dependency via Ahr2 was demonstrated using morpholino knockdown. Hepatocyte ablation demonstrated that hepatic metabolism of BkF was not required for the phenotype, nor was it responsible for the window of sensitivity. RNA sequencing performed on caudal trunk tissue from BkF-exposed animals collected at 48, 60, 72, and 96 hpf showed upregulation of genes associated with AHR activation, appendage development, and tissue patterning. Genes encoding fibroblast growth factor and bone morphogenic protein ligands, along with retinaldehyde dehydrogenase, were prominently upregulated. Gene Ontology term analysis revealed that upregulated genes were enriched for mesoderm development and fin regeneration, whereas downregulated genes were enriched for Wnt signaling and neuronal development. MetaCore (Clarivate Analytics) systems analysis of orthologous human genes predicted that R-SMADs, AP-1, and LEF1 regulated the expression of an enriched number of gene targets across all time points. Our results demonstrate a novel aspect of AHR activity with implications for developmental processes conserved across vertebrate species. The aryl hydrocarbon receptor (AHR) mediates developmental toxicity of several xenobiotic classes including polycyclic aromatic hydrocarbons. Using embryonic zebrafish, we previously identified 4 polycyclic aromatic hydrocarbons that caused a novel phenotype among AHR ligands—growth of a lateral, duplicate caudal fin fold. The window of sensitivity to the most potent inducer of this phenotype, benzo[ k ]fluoranthene (B k F), was prior to 36 h postfertilization (hpf), although the phenotype was not manifest until 60 hpf. AHR dependency via Ahr2 was demonstrated using morpholino knockdown. Hepatocyte ablation demonstrated that hepatic metabolism of B k F was not required for the phenotype, nor was it responsible for the window of sensitivity. RNA sequencing performed on caudal trunk tissue from B k F-exposed animals collected at 48, 60, 72, and 96 hpf showed upregulation of genes associated with AHR activation, appendage development, and tissue patterning. Genes encoding fibroblast growth factor and bone morphogenic protein ligands, along with retinaldehyde dehydrogenase, were prominently upregulated. Gene Ontology term analysis revealed that upregulated genes were enriched for mesoderm development and fin regeneration, whereas downregulated genes were enriched for Wnt signaling and neuronal development. MetaCore (Clarivate Analytics) systems analysis of orthologous human genes predicted that R-SMADs, AP-1, and LEF1 regulated the expression of an enriched number of gene targets across all time points. Our results demonstrate a novel aspect of AHR activity with implications for developmental processes conserved across vertebrate species. |
Author | Brown, Joseph M Shankar, Prarthana Geier, Mitra C Bugel, Sean M Dunham, Cheryl L Garland, Michael A Tanguay, Robyn L Tilton, Susan C |
AuthorAffiliation | k2 Department of Environmental and Molecular Toxicology k4 Computational Biology and Bioinformatics, Pacific Northwest National Laboratories , Richland, Washington 99352 k7 Department of Human Genetics , University of Utah, Salt Lake City, UT 84112 k1 Sinnhuber Aquatic Research Laboratory k6 Department of Pesticide Regulation , California Environmental Protection Agency, Sacramento, CA 95814 k3 Superfund Research Program, Oregon State University , Corvallis, Oregon 97333 k5 Department of Biochemistry and Molecular Medicine , UC Davis School of Medicine, and Institute for Pediatric Regenerative Medicine, Shriners Hospitals for Children-Northern California, Sacramento, CA 95817 |
AuthorAffiliation_xml | – name: k2 Department of Environmental and Molecular Toxicology – name: k5 Department of Biochemistry and Molecular Medicine , UC Davis School of Medicine, and Institute for Pediatric Regenerative Medicine, Shriners Hospitals for Children-Northern California, Sacramento, CA 95817 – name: k1 Sinnhuber Aquatic Research Laboratory – name: k3 Superfund Research Program, Oregon State University , Corvallis, Oregon 97333 – name: k4 Computational Biology and Bioinformatics, Pacific Northwest National Laboratories , Richland, Washington 99352 – name: k6 Department of Pesticide Regulation , California Environmental Protection Agency, Sacramento, CA 95814 – name: k7 Department of Human Genetics , University of Utah, Salt Lake City, UT 84112 |
Author_xml | – sequence: 1 givenname: Michael A surname: Garland fullname: Garland, Michael A organization: Sinnhuber Aquatic Research Laboratory – sequence: 2 givenname: Mitra C surname: Geier fullname: Geier, Mitra C organization: Sinnhuber Aquatic Research Laboratory – sequence: 3 givenname: Sean M surname: Bugel fullname: Bugel, Sean M organization: Sinnhuber Aquatic Research Laboratory – sequence: 4 givenname: Prarthana surname: Shankar fullname: Shankar, Prarthana organization: Sinnhuber Aquatic Research Laboratory – sequence: 5 givenname: Cheryl L orcidid: 0000-0001-7808-3860 surname: Dunham fullname: Dunham, Cheryl L organization: Sinnhuber Aquatic Research Laboratory – sequence: 6 givenname: Joseph M surname: Brown fullname: Brown, Joseph M organization: Computational Biology and Bioinformatics, Pacific Northwest National Laboratories, Richland, Washington 99352 – sequence: 7 givenname: Susan C surname: Tilton fullname: Tilton, Susan C organization: Sinnhuber Aquatic Research Laboratory – sequence: 8 givenname: Robyn L orcidid: 0000-0001-6190-3682 surname: Tanguay fullname: Tanguay, Robyn L email: robyn.tanguay@oregonstate.edu organization: Sinnhuber Aquatic Research Laboratory |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32384158$$D View this record in MEDLINE/PubMed |
BookMark | eNqFkL1PwzAQxS0EAgqsjMgrQ1s7316QoLQUqQgJwcISXZIzNRg7shOg_PUEpVQwMd3p7r3f6d6AbBtrkJBjzkaciXDc2A9fqvGLBGBJuEX2u2kyZCIQ2-s-YRnbIwPvnxnjPGFil-yFQZhFPM72iT53K03nq8rZElxhDb3DEuvGOnqDlYIGPV2AewNNH7FwIJVf0pky9LKttSqhUZ1lZrW278o80elHbX3rkDaWXqD5tFK31oFplmjQH5IdCdrj0boekIfZ9H4yHy5ur64n54thGQVRM4xSKVkUdh_FPGCAPBOpkCALISCSkLI0TlKoIJCZgBCDrksAiywRMs4Qo_CAnPXcui1esSrRNA50Xjv1Cm6VW1D5341Ry_zJvuVpGKc8zTrAqAeUznrvUG68nOXfued97vk6985w8vviRv4TdCc47QW2rf-DfQGDxZWz |
CitedBy_id | crossref_primary_10_3390_toxics11120998 crossref_primary_10_1093_toxsci_kfac037 crossref_primary_10_1016_j_ecoenv_2020_111716 crossref_primary_10_1016_j_jep_2024_118272 crossref_primary_10_1016_j_ecoenv_2023_115471 crossref_primary_10_1093_toxsci_kfaa143 |
Cites_doi | 10.1016/j.mod.2004.08.006 10.1016/j.stem.2012.12.012 10.1016/j.plipres.2017.06.001 10.1007/s00204-017-2068-9 10.1007/s40572-014-0029-5 10.1046/j.1469-7580.2003.00143.x 10.1038/ncb2314 10.1007/978-1-4939-6346-1_10 10.1002/bdra.20216 10.1093/toxsci/68.2.403 10.1002/aja.1002030302 10.1101/gad.1249504 10.1038/nsmb.2000 10.1080/10408449891344263 10.1038/nprot.2009.97 10.1016/S0009-2797(02)00070-4 10.1007/s10552-009-9429-5 10.1016/j.marenvres.2004.03.001 10.1242/jcs.111997 10.1016/S0002-9440(10)64535-X 10.1093/toxsci/kfp189 10.1186/s13059-014-0550-8 10.1093/oxfordjournals.aje.a009451 10.1016/j.bcp.2008.11.021 10.1242/dev.125.13.2499 10.1002/1097-0177(2000)9999:9999<::AID-DVDY1054>3.3.CO;2-5 10.1016/j.taap.2011.09.020 10.1371/journal.pone.0111670 10.1016/j.toxrep.2017.04.005 10.1016/j.aquatox.2010.09.016 10.1016/j.taap.2013.05.006 10.1006/dbio.1996.0126 10.1126/scisignal.aal1910 10.1111/j.1469-7580.2012.01491.x 10.1093/toxsci/kfx035 10.1289/ehp.8230 10.1093/bioinformatics/btw313 10.12688/f1000research.7563.1 10.1016/j.bcp.2008.08.031 10.1074/jbc.M110.187534 10.1096/fj.08-109009 10.1002/gene.10095 10.1101/cshperspect.a007955 10.1042/BJ20050713 10.1371/journal.pbio.0040115 10.1016/j.chemosphere.2008.05.025 10.1371/journal.pone.0073169 10.1016/j.taap.2011.09.010 10.1093/bioinformatics/btu170 10.1242/dev.122.11.3487 10.1007/s00427-016-0533-8 10.1186/1471-2105-13-311 10.1016/j.taap.2013.04.024 10.1126/science.1176676 10.1093/humrep/dem300 10.1007/s11356-014-3627-8 10.1016/S0925-4773(02)00327-1 10.1016/j.matbio.2013.10.011 10.1093/toxsci/kfl011 10.1093/toxsci/kfq179 10.1093/carcin/9.7.1277 10.1016/j.envres.2013.12.002 10.1002/cpbi.5 10.1016/j.devcel.2014.09.018 10.1016/j.mcn.2006.03.005 10.1016/j.ydbio.2013.02.023 10.1093/toxsci/kfs253 10.1093/aje/kwr455 10.1093/toxsci/kfj118 10.1242/dev.123.1.95 10.1074/jbc.273.4.1839 10.1177/2211068211432197 10.1016/j.gde.2009.05.005 10.1093/toxsci/kfg202 10.1242/dev.022202 10.1016/j.envres.2015.03.017 10.12688/f1000research.7035.2 10.3389/fcell.2016.00045 10.1289/EHP3281 10.1038/nmeth.3252 10.1007/978-3-319-24277-4 10.1016/j.envint.2010.05.003 10.1093/bioinformatics/bti525 10.1016/j.neuro.2004.07.007 10.1089/wound.2013.0512 10.1038/nmeth.4197 10.1002/dvdy.21100 10.1542/peds.2008-3506 10.1146/annurev.cellbio.12.1.55 10.1038/ng.186 10.1101/gr.1239303 10.1124/mol.105.018044 10.1016/0045-6535(92)90482-7 10.1016/j.clim.2006.01.016 10.1093/toxsci/kfu245 |
ContentType | Journal Article |
Copyright | The Author(s) 2020. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2020 The Author(s) 2020. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. |
Copyright_xml | – notice: The Author(s) 2020. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2020 – notice: The Author(s) 2020. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. |
DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 5PM |
DOI | 10.1093/toxsci/kfaa063 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef PubMed Central (Full Participant titles) |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef |
DatabaseTitleList | CrossRef MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine Public Health Pharmacy, Therapeutics, & Pharmacology |
EISSN | 1096-0929 |
EndPage | 64 |
ExternalDocumentID | 10_1093_toxsci_kfaa063 32384158 10.1093/toxsci/kfaa063 |
Genre | Journal Article Research Support, N.I.H., Extramural |
GrantInformation_xml | – fundername: NIEHS NIH HHS grantid: P42 ES016465 – fundername: NIEHS NIH HHS grantid: K99 ES025280 – fundername: NIEHS NIH HHS grantid: T32 ES007060 – fundername: ; ; grantid: P42 ES016465; T32 ES007060 |
GroupedDBID | --- -E4 .2P .I3 .ZR 0R~ 123 18M 1TH 1~5 29Q 2WC 4.4 48X 4G. 53G 5RE 5VS 5WA 5WD 7-5 70D A8Z AABZA AACTN AACZT AAHBH AAIMJ AAJKP AAMDB AAMVS AAOGV AAPNW AAPQZ AAPXW AARHZ AASNB AAUAY AAUQX AAVAP AAVLN ABEUO ABIXL ABJNI ABKDP ABMNT ABNHQ ABNKS ABPTD ABQLI ABWST ABXVV ABZBJ ACGFO ACGFS ACUFI ACUTJ ACUTO ADBBV ADEYI ADEZT ADGKP ADGZP ADHKW ADHZD ADIPN ADJQC ADOCK ADQBN ADRIX ADRTK ADVEK ADYVW ADZTZ ADZXQ AEGPL AEGXH AEJOX AEKSI AELWJ AEMDU AENEX AENZO AEPUE AETBJ AEWNT AFFZL AFGWE AFIYH AFOFC AFXEN AGINJ AGKEF AGQXC AGSYK AHXPO AIJHB AJEEA AKHUL AKRWK AKWXX ALMA_UNASSIGNED_HOLDINGS ALUQC APIBT APWMN ARIXL ATGXG AXUDD AYOIW BAWUL BAYMD BCRHZ BEYMZ BHONS BQDIO BSWAC BTRTY BVRKM CDBKE CS3 CZ4 DAKXR DIK DILTD DU5 D~K E3Z EBD EBS EDH EE~ EMOBN ESTFP F5P F9B FDB FHSFR FLUFQ FOEOM FOTVD FQBLK GAUVT GJXCC GX1 H13 H5~ HAR HH5 HW0 HZ~ I-F IOX J21 KAQDR KBUDW KOP KQ8 KSI KSN M-Z M49 N9A NGC NLBLG NOMLY NOYVH NQ- NU- O-L O9- OAWHX OBOKY OCZFY ODMLO OJQWA OJZSN OK1 OPAEJ OWPYF P2P PAFKI PEELM Q1. Q5Y R44 RD5 ROL ROX RUSNO RW1 RXO SV3 TJX TLC TR2 W8F WOQ X7H YAYTL YKOAZ YXANX ZKX ~02 ~91 CGR CUY CVF ECM EIF NPM AAYXX CITATION 5PM |
ID | FETCH-LOGICAL-c424t-47ff043aa05120ae18979fafb99a4fa707567ada2f89a3e2da26aeb869f58ee43 |
ISSN | 1096-6080 |
IngestDate | Tue Sep 17 21:11:34 EDT 2024 Fri Aug 23 00:38:39 EDT 2024 Sun Oct 13 09:30:07 EDT 2024 Wed Aug 28 03:17:50 EDT 2024 |
IsDoiOpenAccess | false |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 1 |
Keywords | RNA sequencing fluoranthene benzo appendage benzo[k]fluoranthene |
Language | English |
License | This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) The Author(s) 2020. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-c424t-47ff043aa05120ae18979fafb99a4fa707567ada2f89a3e2da26aeb869f58ee43 |
Notes | Michael A. Garland and Mitra C. Geier contributed equally to this study. |
ORCID | 0000-0001-7808-3860 0000-0001-6190-3682 |
OpenAccessLink | https://academic.oup.com/toxsci/article-pdf/176/1/46/33490037/kfaa063.pdf |
PMID | 32384158 |
PageCount | 19 |
ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_7357178 crossref_primary_10_1093_toxsci_kfaa063 pubmed_primary_32384158 oup_primary_10_1093_toxsci_kfaa063 |
PublicationCentury | 2000 |
PublicationDate | 2020-07-01 |
PublicationDateYYYYMMDD | 2020-07-01 |
PublicationDate_xml | – month: 07 year: 2020 text: 2020-07-01 day: 01 |
PublicationDecade | 2020 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States |
PublicationTitle | Toxicological sciences |
PublicationTitleAlternate | Toxicol Sci |
PublicationYear | 2020 |
Publisher | Oxford University Press |
Publisher_xml | – name: Oxford University Press |
References | Park (2020071306124035800_kfaa063-B69) 2006; 119 Perera (2020071306124035800_kfaa063-B74) 1998; 147 (2020071306124035800_kfaa063-B77) 2017 Truong (2020071306124035800_kfaa063-B94) 2016; 1473 Genkinger (2020071306124035800_kfaa063-B25) 2015; 140 Arnold (2020071306124035800_kfaa063-B4) 2017 Ng (2020071306124035800_kfaa063-B62) 2010; 21 Yamamoto-Shiraishi (2020071306124035800_kfaa063-B101) 2013; 377 Giri (2020071306124035800_kfaa063-B28) 2000; 157 Knecht (2020071306124035800_kfaa063-B47) 2013; 271 Sauzeau (2020071306124035800_kfaa063-B81) 2011; 286 Tilton (2020071306124035800_kfaa063-B93) 2012; 13 Kee (2020071306124035800_kfaa063-B43) 2010; 117 Hikasa (2020071306124035800_kfaa063-B34) 2013; 5 Gu (2020071306124035800_kfaa063-B30) 2016; 32 Tanaka (2020071306124035800_kfaa063-B91) 2000; 219 Perera (2020071306124035800_kfaa063-B73) 2005; 26 Seijffers (2020071306124035800_kfaa063-B84) 2006; 32 Perera (2020071306124035800_kfaa063-B71) 2014; 9 Goodale (2020071306124035800_kfaa063-B29) 2013; 272 Gibson-Brown (2020071306124035800_kfaa063-B26) 1998; 125 Ma (2020071306124035800_kfaa063-B53) 2011; 18 Kimmel (2020071306124035800_kfaa063-B46) 1995; 203 Kim (2020071306124035800_kfaa063-B45) 2009; 112 Nebert (2020071306124035800_kfaa063-B61) 2017; 67 Perera (2020071306124035800_kfaa063-B72) 2009; 124 Mathew (2020071306124035800_kfaa063-B55) 2006; 69 Scott (2020071306124035800_kfaa063-B83) 2011; 101 Yamaji (2020071306124035800_kfaa063-B99) 2008; 40 Yano (2020071306124035800_kfaa063-B102) 2013; 222 Bobick (2020071306124035800_kfaa063-B9) 2012; 125 Love (2020071306124035800_kfaa063-B52) 2014; 15 Jayasundara (2020071306124035800_kfaa063-B39) 2015; 143 Giesy (2020071306124035800_kfaa063-B27) 1998; 28 Mikels (2020071306124035800_kfaa063-B57) 2006; 4 Bugel (2020071306124035800_kfaa063-B11) 2014; 1 Incardona (2020071306124035800_kfaa063-B38) 2011; 257 Wu (2020071306124035800_kfaa063-B98) 2017; 10 Alexa (2020071306124035800_kfaa063-B1) 2010; 2 Levin (2020071306124035800_kfaa063-B48) 2005; 122 Slowikowski (2020071306124035800_kfaa063-B87) 2017 Billiard (2020071306124035800_kfaa063-B8) 2006; 92 Sasagawa (2020071306124035800_kfaa063-B80) 2002; 33 Andreasen (2020071306124035800_kfaa063-B2) 2006; 92 Carney (2020071306124035800_kfaa063-B12) 2006; 76 Shannon (2020071306124035800_kfaa063-B85) 2003; 13 Andreasen (2020071306124035800_kfaa063-B3) 2002; 68 Coutts (2020071306124035800_kfaa063-B15) 2007; 22 Rundle (2020071306124035800_kfaa063-B79) 2012; 175 Simone (2020071306124035800_kfaa063-B86) 2014; 3 Karchner (2020071306124035800_kfaa063-B42) 2005; 392 Curado (2020071306124035800_kfaa063-B17) 2007; 236 Mullen (2020071306124035800_kfaa063-B60) 1996; 122 Osterwalder (2020071306124035800_kfaa063-B68) 2014; 31 Puga (2020071306124035800_kfaa063-B76) 2009; 77 Bolger (2020071306124035800_kfaa063-B10) 2014; 30 Mathew (2020071306124035800_kfaa063-B56) 2008; 22 Jung (2020071306124035800_kfaa063-B41) 2014; 128 Incardona (2020071306124035800_kfaa063-B37) 2005; 113 Wickham (2020071306124035800_kfaa063-B97) 2016 Kerkvliet (2020071306124035800_kfaa063-B44) 2009; 77 Suzuki (2020071306124035800_kfaa063-B90) 2010; 36 Prasch (2020071306124035800_kfaa063-B75) 2003; 76 Durinck (2020071306124035800_kfaa063-B19) 2009; 4 Yamaji (2020071306124035800_kfaa063-B100) 2013; 12 Gutkind (2020071306124035800_kfaa063-B31) 1998; 273 Ober (2020071306124035800_kfaa063-B65) 2003; 120 Lonai (2020071306124035800_kfaa063-B50) 2003; 202 Hahn (2020071306124035800_kfaa063-B32) 2002; 141 Galceran (2020071306124035800_kfaa063-B22) 2004; 18 Olson (2020071306124035800_kfaa063-B67) 1992; 25 Mulero-Navarro (2020071306124035800_kfaa063-B59) 2016; 4 Bikoff (2020071306124035800_kfaa063-B7) 2009; 19 Huber (2020071306124035800_kfaa063-B35) 2015; 12 Hwang (2020071306124035800_kfaa063-B36) 2008; 135 Chlebowski (2020071306124035800_kfaa063-B13) 2017; 157 Barron (2020071306124035800_kfaa063-B5) 2004; 58 Weyand (2020071306124035800_kfaa063-B96) 1988; 9 Mandrell (2020071306124035800_kfaa063-B54) 2012; 17 Jedrychowski (2020071306124035800_kfaa063-B40) 2015; 22 Niederreither (2020071306124035800_kfaa063-B63) 1996; 176 Stelzer (2020071306124035800_kfaa063-B89) 2016; 54 (2020071306124035800_kfaa063-B78) 2016 Durinck (2020071306124035800_kfaa063-B18) 2005; 21 Bengtsson (2020071306124035800_kfaa063-B6) 2017 Geier (2020071306124035800_kfaa063-B24) 2018; 92 Ten Berge (2020071306124035800_kfaa063-B92) 2011; 13 Soneson (2020071306124035800_kfaa063-B88) 2015; 4 Crowell (2020071306124035800_kfaa063-B16) 2011; 257 Hammerschmidt (2020071306124035800_kfaa063-B33) 1996; 123 Moreno-Layseca (2020071306124035800_kfaa063-B58) 2014; 34 Garcia (2020071306124035800_kfaa063-B23) 2018; 126 Oliveros (2020071306124035800_kfaa063-B66) 2016 Wahl (2020071306124035800_kfaa063-B95) 2008; 73 Patro (2020071306124035800_kfaa063-B70) 2017; 14 Lo (2020071306124035800_kfaa063-B49) 2012; 130 Fabian (2020071306124035800_kfaa063-B20) 2016; 226 Nurieva (2020071306124035800_kfaa063-B64) 2009; 325 Schmidt (2020071306124035800_kfaa063-B82) 1996; 12 Chlebowski (2020071306124035800_kfaa063-B14) 2017; 4 Forrest (2020071306124035800_kfaa063-B21) 2013; 8 Love (2020071306124035800_kfaa063-B51) 2016; 4 |
References_xml | – year: 2017 ident: 2020071306124035800_kfaa063-B6 contributor: fullname: Bengtsson – volume: 122 start-page: 3 year: 2005 ident: 2020071306124035800_kfaa063-B48 article-title: Left-right asymmetry in embryonic development: A comprehensive review publication-title: Mech. Dev doi: 10.1016/j.mod.2004.08.006 contributor: fullname: Levin – volume: 12 start-page: 368 year: 2013 ident: 2020071306124035800_kfaa063-B100 article-title: PRDM14 ensures naive pluripotency through dual regulation of signaling and epigenetic pathways in mouse embryonic stem cells publication-title: Cell Stem Cell doi: 10.1016/j.stem.2012.12.012 contributor: fullname: Yamaji – volume: 67 start-page: 38 year: 2017 ident: 2020071306124035800_kfaa063-B61 article-title: Aryl hydrocarbon receptor (AHR): “Pioneer member” of the basic-helix/loop/helix per-Arnt-sim (bHLH/Pas) family of “sensors” of foreign and endogenous signals publication-title: Prog. Lipid Res doi: 10.1016/j.plipres.2017.06.001 contributor: fullname: Nebert – volume: 92 start-page: 571 year: 2018 ident: 2020071306124035800_kfaa063-B24 article-title: Comparative developmental toxicity of a comprehensive suite of polycyclic aromatic hydrocarbons publication-title: Arch. Toxicol doi: 10.1007/s00204-017-2068-9 contributor: fullname: Geier – volume: 1 start-page: 341 year: 2014 ident: 2020071306124035800_kfaa063-B11 article-title: Zebrafish: A marvel of high-throughput biology for 21(st) century toxicology publication-title: Curr. Environ. Health Rep doi: 10.1007/s40572-014-0029-5 contributor: fullname: Bugel – volume: 202 start-page: 43 year: 2003 ident: 2020071306124035800_kfaa063-B50 article-title: Epithelial mesenchymal interactions, the ECM and limb development publication-title: J. Anat doi: 10.1046/j.1469-7580.2003.00143.x contributor: fullname: Lonai – volume: 2 start-page: 2010 year: 2010 ident: 2020071306124035800_kfaa063-B1 article-title: topGO: Enrichment analysis for gene ontology publication-title: R Package Version contributor: fullname: Alexa – volume: 13 start-page: 1070 year: 2011 ident: 2020071306124035800_kfaa063-B92 article-title: Embryonic stem cells require Wnt proteins to prevent differentiation to epiblast stem cells publication-title: Nat. Cell Biol doi: 10.1038/ncb2314 contributor: fullname: Ten Berge – volume: 1473 start-page: 89 year: 2016 ident: 2020071306124035800_kfaa063-B94 article-title: Better, faster, cheaper: Getting the most out of high-throughput screening with zebrafish publication-title: Methods Mol. Biol doi: 10.1007/978-1-4939-6346-1_10 contributor: fullname: Truong – volume: 76 start-page: 7 year: 2006 ident: 2020071306124035800_kfaa063-B12 article-title: Understanding dioxin developmental toxicity using the zebrafish model publication-title: Birth Defects Res. A Clin. Mol. Teratol doi: 10.1002/bdra.20216 contributor: fullname: Carney – volume: 68 start-page: 403 year: 2002 ident: 2020071306124035800_kfaa063-B3 article-title: Tissue-specific expression of AHR2, ARNT2, and CYP1A in zebrafish embryos and larvae: Effects of developmental stage and 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure publication-title: Toxicol. Sci doi: 10.1093/toxsci/68.2.403 contributor: fullname: Andreasen – volume: 203 start-page: 253 year: 1995 ident: 2020071306124035800_kfaa063-B46 article-title: Stages of embryonic development of the zebrafish publication-title: Dev. Dyn doi: 10.1002/aja.1002030302 contributor: fullname: Kimmel – volume: 18 start-page: 2718 year: 2004 ident: 2020071306124035800_kfaa063-B22 article-title: LEF1-mediated regulation of delta-like1 links Wnt and notch signaling in somitogenesis publication-title: Genes Dev doi: 10.1101/gad.1249504 contributor: fullname: Galceran – volume: 18 start-page: 120 year: 2011 ident: 2020071306124035800_kfaa063-B53 article-title: Sequence-specific regulator PRDM14 safeguards mouse ESCs from entering extraembryonic endoderm fates publication-title: Nat. Struct. Mol. Biol doi: 10.1038/nsmb.2000 contributor: fullname: Ma – volume: 28 start-page: 511 year: 1998 ident: 2020071306124035800_kfaa063-B27 article-title: Dioxin-like and non-dioxin-like toxic effects of polychlorinated biphenyls (PCBs): Implications for risk assessment publication-title: Crit. Rev. Toxicol doi: 10.1080/10408449891344263 contributor: fullname: Giesy – year: 2017 ident: 2020071306124035800_kfaa063-B77 – volume: 4 start-page: 1184 year: 2009 ident: 2020071306124035800_kfaa063-B19 article-title: Mapping identifiers for the integration of genomic datasets with the R/Bioconductor package biomaRt publication-title: Nat. Protoc doi: 10.1038/nprot.2009.97 contributor: fullname: Durinck – volume: 141 start-page: 131 year: 2002 ident: 2020071306124035800_kfaa063-B32 article-title: Aryl hydrocarbon receptors: Diversity and evolution publication-title: Chem. Biol. Interact doi: 10.1016/S0009-2797(02)00070-4 contributor: fullname: Hahn – volume: 21 start-page: 11 year: 2010 ident: 2020071306124035800_kfaa063-B62 article-title: Interaction between organochlorines and the AHR gene, and risk of non-Hodgkin lymphoma publication-title: Cancer Cause Control doi: 10.1007/s10552-009-9429-5 contributor: fullname: Ng – volume: 58 start-page: 95 year: 2004 ident: 2020071306124035800_kfaa063-B5 article-title: Relative potency of PAHs and heterocycles as aryl hydrocarbon receptor agonists in fish publication-title: Mar. Environ. Res doi: 10.1016/j.marenvres.2004.03.001 contributor: fullname: Barron – volume: 125 start-page: 6071 year: 2012 ident: 2020071306124035800_kfaa063-B9 article-title: Shox2 regulates progression through chondrogenesis in the mouse proximal limb publication-title: J. Cell Sci doi: 10.1242/jcs.111997 contributor: fullname: Bobick – volume-title: RStudio: Integrated Development for R year: 2016 ident: 2020071306124035800_kfaa063-B78 – volume: 157 start-page: 249 year: 2000 ident: 2020071306124035800_kfaa063-B28 article-title: Interleukin-1 alpha is a paracrine inducer of FGF7, a key epithelial growth factor in benign prostatic hyperplasia publication-title: Am. J. Pathol doi: 10.1016/S0002-9440(10)64535-X contributor: fullname: Giri – volume: 112 start-page: 229 year: 2009 ident: 2020071306124035800_kfaa063-B45 article-title: Comparative analysis of AHR-mediated TCDD-elicited gene expression in human liver adult stem cells publication-title: Toxicol. Sci doi: 10.1093/toxsci/kfp189 contributor: fullname: Kim – volume: 15 start-page: 550 year: 2014 ident: 2020071306124035800_kfaa063-B52 article-title: Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 publication-title: Genome Biol doi: 10.1186/s13059-014-0550-8 contributor: fullname: Love – volume: 147 start-page: 309 year: 1998 ident: 2020071306124035800_kfaa063-B74 article-title: Recent developments in molecular epidemiology: A study of the effects of environmental polycyclic aromatic hydrocarbons on birth outcomes in Poland publication-title: Am. J. Epidemiol doi: 10.1093/oxfordjournals.aje.a009451 contributor: fullname: Perera – volume: 77 start-page: 746 year: 2009 ident: 2020071306124035800_kfaa063-B44 article-title: AHR-mediated immunomodulation: The role of altered gene transcription publication-title: Biochem. Pharmacol doi: 10.1016/j.bcp.2008.11.021 contributor: fullname: Kerkvliet – volume: 125 start-page: 2499 year: 1998 ident: 2020071306124035800_kfaa063-B26 article-title: Involvement of T-box genes Tbx2-Tbx5 in vertebrate limb specification and development publication-title: Development doi: 10.1242/dev.125.13.2499 contributor: fullname: Gibson-Brown – volume: 219 start-page: 248 year: 2000 ident: 2020071306124035800_kfaa063-B91 article-title: Nkx3.1, a murine homolog of drosophila bagpipe, regulates epithelial ductal branching and proliferation of the prostate and palatine glands publication-title: Dev. Dyn doi: 10.1002/1097-0177(2000)9999:9999<::AID-DVDY1054>3.3.CO;2-5 contributor: fullname: Tanaka – volume: 257 start-page: 365 year: 2011 ident: 2020071306124035800_kfaa063-B16 article-title: Preliminary physiologically based pharmacokinetic models for benzo[a]pyrene and dibenzo[def,p]chrysene in rodents publication-title: Toxicol. Appl. Pharmacol doi: 10.1016/j.taap.2011.09.020 contributor: fullname: Crowell – volume: 9 start-page: e111670 year: 2014 ident: 2020071306124035800_kfaa063-B71 article-title: Early-life exposure to polycyclic aromatic hydrocarbons and ADHD behavior problems publication-title: PLoS One doi: 10.1371/journal.pone.0111670 contributor: fullname: Perera – volume: 4 start-page: 202 year: 2017 ident: 2020071306124035800_kfaa063-B14 article-title: Investigating the application of a nitroreductase-expressing transgenic zebrafish line for high-throughput toxicity testing publication-title: Toxicol. Rep doi: 10.1016/j.toxrep.2017.04.005 contributor: fullname: Chlebowski – volume: 101 start-page: 165 year: 2011 ident: 2020071306124035800_kfaa063-B83 article-title: AhR2-mediated, CYP1A-independent cardiovascular toxicity in zebrafish (Danio rerio) embryos exposed to retene publication-title: Aquat. Toxicol doi: 10.1016/j.aquatox.2010.09.016 contributor: fullname: Scott – year: 2017 ident: 2020071306124035800_kfaa063-B4 contributor: fullname: Arnold – volume: 271 start-page: 266 year: 2013 ident: 2020071306124035800_kfaa063-B47 article-title: Comparative developmental toxicity of environmentally relevant oxygenated PAHs publication-title: Toxicol. Appl. Pharmacol doi: 10.1016/j.taap.2013.05.006 contributor: fullname: Knecht – volume: 176 start-page: 185 year: 1996 ident: 2020071306124035800_kfaa063-B63 article-title: Morphological and molecular characterization of retinoic acid-induced limb duplications in mice publication-title: Dev. Biol doi: 10.1006/dbio.1996.0126 contributor: fullname: Niederreither – volume: 10 start-page: eaal1910 year: 2017 ident: 2020071306124035800_kfaa063-B98 article-title: BMP8A sustains spermatogenesis by activating both Smad1/5/8 and Smad2/3 in spermatogonia publication-title: Sci. Signal. doi: 10.1126/scisignal.aal1910 contributor: fullname: Wu – volume: 222 start-page: 100 year: 2013 ident: 2020071306124035800_kfaa063-B102 article-title: The making of differences between fins and limbs publication-title: J. Anat doi: 10.1111/j.1469-7580.2012.01491.x contributor: fullname: Yano – volume: 157 start-page: 246 year: 2017 ident: 2020071306124035800_kfaa063-B13 article-title: Mechanistic investigations into the developmental toxicity of nitrated and heterocyclic PAHs publication-title: Toxicol. Sci doi: 10.1093/toxsci/kfx035 contributor: fullname: Chlebowski – volume: 113 start-page: 1755 year: 2005 ident: 2020071306124035800_kfaa063-B37 article-title: Aryl hydrocarbon receptor-independent toxicity of weathered crude oil during fish development publication-title: Environ. Health Perspect doi: 10.1289/ehp.8230 contributor: fullname: Incardona – volume: 32 start-page: 2847 year: 2016 ident: 2020071306124035800_kfaa063-B30 article-title: Complex heatmaps reveal patterns and correlations in multidimensional genomic data publication-title: Bioinformatics doi: 10.1093/bioinformatics/btw313 contributor: fullname: Gu – volume: 4 start-page: 1521 year: 2015 ident: 2020071306124035800_kfaa063-B88 article-title: Differential analyses for RNA-seq: Transcript-level estimates improve gene-level inferences publication-title: F1000Res doi: 10.12688/f1000research.7563.1 contributor: fullname: Soneson – volume: 77 start-page: 713 year: 2009 ident: 2020071306124035800_kfaa063-B76 article-title: The aryl hydrocarbon receptor cross-talks with multiple signal transduction pathways publication-title: Biochem. Pharmacol doi: 10.1016/j.bcp.2008.08.031 contributor: fullname: Puga – volume: 286 start-page: 2896 year: 2011 ident: 2020071306124035800_kfaa063-B81 article-title: Transcriptional factor aryl hydrocarbon receptor (AHR) controls cardiovascular and respiratory functions by regulating the expression of the Vav3 proto-oncogene publication-title: J. Biol. Chem doi: 10.1074/jbc.M110.187534 contributor: fullname: Sauzeau – year: 2017 ident: 2020071306124035800_kfaa063-B87 contributor: fullname: Slowikowski – volume: 22 start-page: 3087 year: 2008 ident: 2020071306124035800_kfaa063-B56 article-title: Crosstalk between AHR and Wnt signaling through R-Spondin1 impairs tissue regeneration in zebrafish publication-title: FASEB J doi: 10.1096/fj.08-109009 contributor: fullname: Mathew – volume: 33 start-page: 86 year: 2002 ident: 2020071306124035800_kfaa063-B80 article-title: Axes establishment during eye morphogenesis in Xenopus by coordinate and antagonistic actions of BMP4, Shh, and RA publication-title: Genesis doi: 10.1002/gene.10095 contributor: fullname: Sasagawa – volume: 5 start-page: a007955 year: 2013 ident: 2020071306124035800_kfaa063-B34 article-title: Wnt signaling in vertebrate axis specification publication-title: Cold Spring Harb. Perspect. Biol. doi: 10.1101/cshperspect.a007955 contributor: fullname: Hikasa – volume: 392 start-page: 153 year: 2005 ident: 2020071306124035800_kfaa063-B42 article-title: AHR1B, a new functional aryl hydrocarbon receptor in zebrafish: tandem arrangement of ahr1b and ahr2 genes publication-title: Biochem. J. doi: 10.1042/BJ20050713 contributor: fullname: Karchner – volume: 4 start-page: e115 year: 2006 ident: 2020071306124035800_kfaa063-B57 article-title: Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context publication-title: PLoS Biol doi: 10.1371/journal.pbio.0040115 contributor: fullname: Mikels – volume: 73 start-page: 209 year: 2008 ident: 2020071306124035800_kfaa063-B95 article-title: A technical mixture of 2,2′,4,4′-tetrabromo diphenyl ether (BDE47) and brominated furans triggers aryl hydrocarbon receptor (AHR) mediated gene expression and toxicity publication-title: Chemosphere doi: 10.1016/j.chemosphere.2008.05.025 contributor: fullname: Wahl – volume: 8 start-page: e73169 year: 2013 ident: 2020071306124035800_kfaa063-B21 article-title: Knockdown of human TCF4 affects multiple signaling pathways involved in cell survival, epithelial to mesenchymal transition and neuronal differentiation publication-title: PLoS One doi: 10.1371/journal.pone.0073169 contributor: fullname: Forrest – volume: 257 start-page: 242 year: 2011 ident: 2020071306124035800_kfaa063-B38 article-title: Cardiac toxicity of 5-ring polycyclic aromatic hydrocarbons is differentially dependent on the aryl hydrocarbon receptor 2 isoform during zebrafish development publication-title: Toxicol. Appl. Pharmacol doi: 10.1016/j.taap.2011.09.010 contributor: fullname: Incardona – year: 2016 ident: 2020071306124035800_kfaa063-B66 contributor: fullname: Oliveros – volume: 30 start-page: 2114 year: 2014 ident: 2020071306124035800_kfaa063-B10 article-title: Trimmomatic: A flexible trimmer for Illumina sequence data publication-title: Bioinformatics doi: 10.1093/bioinformatics/btu170 contributor: fullname: Bolger – volume: 122 start-page: 3487 year: 1996 ident: 2020071306124035800_kfaa063-B60 article-title: Nerve dependency of regeneration: The role of Distal-less and FGF signaling in amphibian limb regeneration publication-title: Development doi: 10.1242/dev.122.11.3487 contributor: fullname: Mullen – volume: 226 start-page: 99 year: 2016 ident: 2020071306124035800_kfaa063-B20 article-title: Vox homeobox gene: A novel regulator of midbrain-hindbrain boundary development in medaka fish? publication-title: Dev. Genes Evol doi: 10.1007/s00427-016-0533-8 contributor: fullname: Fabian – volume: 13 start-page: 311 year: 2012 ident: 2020071306124035800_kfaa063-B93 article-title: Bioinformatics resource manager v2.3: An integrated software environment for systems biology with microRNA and cross-species analysis tools publication-title: BMC Bioinformatics doi: 10.1186/1471-2105-13-311 contributor: fullname: Tilton – volume: 272 start-page: 656 year: 2013 ident: 2020071306124035800_kfaa063-B29 article-title: Structurally distinct polycyclic aromatic hydrocarbons induce differential transcriptional responses in developing zebrafish publication-title: Toxicol. Appl. Pharmacol doi: 10.1016/j.taap.2013.04.024 contributor: fullname: Goodale – volume: 325 start-page: 1001 year: 2009 ident: 2020071306124035800_kfaa063-B64 article-title: Bcl6 mediates the development of T follicular helper cells publication-title: Science doi: 10.1126/science.1176676 contributor: fullname: Nurieva – volume: 22 start-page: 2912 year: 2007 ident: 2020071306124035800_kfaa063-B15 article-title: Environmental toxicant-induced germ cell apoptosis in the human fetal testis publication-title: Hum. Reprod doi: 10.1093/humrep/dem300 contributor: fullname: Coutts – volume: 22 start-page: 3631 year: 2015 ident: 2020071306124035800_kfaa063-B40 article-title: Prenatal exposure to polycyclic aromatic hydrocarbons and cognitive dysfunction in children publication-title: Environ. Sci. Pollut. Res. Int doi: 10.1007/s11356-014-3627-8 contributor: fullname: Jedrychowski – volume: 120 start-page: 5 year: 2003 ident: 2020071306124035800_kfaa063-B65 article-title: From endoderm formation to liver and pancreas development in zebrafish publication-title: Mech. Dev doi: 10.1016/S0925-4773(02)00327-1 contributor: fullname: Ober – volume: 34 start-page: 144 year: 2014 ident: 2020071306124035800_kfaa063-B58 article-title: Signalling pathways linking integrins with cell cycle progression publication-title: Matrix Biol doi: 10.1016/j.matbio.2013.10.011 contributor: fullname: Moreno-Layseca – volume: 92 start-page: 526 year: 2006 ident: 2020071306124035800_kfaa063-B8 article-title: The role of the aryl hydrocarbon receptor pathway in mediating synergistic developmental toxicity of polycyclic aromatic hydrocarbons to zebrafish publication-title: Toxicol. Sci doi: 10.1093/toxsci/kfl011 contributor: fullname: Billiard – volume: 117 start-page: 218 year: 2010 ident: 2020071306124035800_kfaa063-B43 article-title: Human primordial germ cell formation is diminished by exposure to environmental toxicants acting through the AHR signaling pathway publication-title: Toxicol. Sci doi: 10.1093/toxsci/kfq179 contributor: fullname: Kee – volume: 9 start-page: 1277 year: 1988 ident: 2020071306124035800_kfaa063-B96 article-title: Metabolism and mutagenic activity of benzo[k]fluoranthene and 3-flurobenzo[k]fluoranthene, 8-flurobenzo[k]fluoranthene and 9-fluorobenzo[k]fluoranthene publication-title: Carcinogenesis doi: 10.1093/carcin/9.7.1277 contributor: fullname: Weyand – volume: 128 start-page: 35 year: 2014 ident: 2020071306124035800_kfaa063-B41 article-title: Polycyclic aromatic hydrocarbon exposure, obesity and childhood asthma in an urban cohort publication-title: Environ. Res doi: 10.1016/j.envres.2013.12.002 contributor: fullname: Jung – volume: 54 year: 2016 ident: 2020071306124035800_kfaa063-B89 article-title: The GeneCards suite: From gene data mining to disease genome sequence analyses publication-title: Curr. Protoc. Bioinform doi: 10.1002/cpbi.5 contributor: fullname: Stelzer – volume: 31 start-page: 345 year: 2014 ident: 2020071306124035800_kfaa063-B68 article-title: HAND2 targets define a network of transcriptional regulators that compartmentalize the early limb bud mesenchyme publication-title: Dev. Cell doi: 10.1016/j.devcel.2014.09.018 contributor: fullname: Osterwalder – volume: 32 start-page: 143 year: 2006 ident: 2020071306124035800_kfaa063-B84 article-title: The transcription factor ATF-3 promotes neurite outgrowth publication-title: Mol. Cell. Neurosci doi: 10.1016/j.mcn.2006.03.005 contributor: fullname: Seijffers – volume: 377 start-page: 363 year: 2013 ident: 2020071306124035800_kfaa063-B101 article-title: Wnt and BMP signaling cooperate with Hox in the control of Six2 expression in limb tendon precursor publication-title: Dev. Biol doi: 10.1016/j.ydbio.2013.02.023 contributor: fullname: Yamamoto-Shiraishi – volume: 130 start-page: 349 year: 2012 ident: 2020071306124035800_kfaa063-B49 article-title: High-resolution genome-wide mapping of AHR and ARNT binding sites by ChIP-Seq publication-title: Toxicol. Sci doi: 10.1093/toxsci/kfs253 contributor: fullname: Lo – volume: 175 start-page: 1163 year: 2012 ident: 2020071306124035800_kfaa063-B79 article-title: Association of childhood obesity with maternal exposure to ambient air polycyclic aromatic hydrocarbons during pregnancy publication-title: Am. J. Epidemiol doi: 10.1093/aje/kwr455 contributor: fullname: Rundle – volume: 92 start-page: 254 year: 2006 ident: 2020071306124035800_kfaa063-B2 article-title: Regenerative growth is impacted by TCDD: Gene expression analysis reveals extracellular matrix modulation publication-title: Toxicol. Sci doi: 10.1093/toxsci/kfj118 contributor: fullname: Andreasen – volume: 123 start-page: 95 year: 1996 ident: 2020071306124035800_kfaa063-B33 article-title: Dino and mercedes, two genes regulating dorsal development in the zebrafish embryo publication-title: Development doi: 10.1242/dev.123.1.95 contributor: fullname: Hammerschmidt – volume: 273 start-page: 1839 year: 1998 ident: 2020071306124035800_kfaa063-B31 article-title: The pathways connecting G protein-coupled receptors to the nucleus through divergent mitogen-activated protein kinase cascades publication-title: J. Biol. Chem doi: 10.1074/jbc.273.4.1839 contributor: fullname: Gutkind – volume: 17 start-page: 66 year: 2012 ident: 2020071306124035800_kfaa063-B54 article-title: Automated zebrafish chorion removal and single embryo placement: Optimizing throughput of zebrafish developmental toxicity screens publication-title: J. Lab. Autom doi: 10.1177/2211068211432197 contributor: fullname: Mandrell – volume: 19 start-page: 379 year: 2009 ident: 2020071306124035800_kfaa063-B7 article-title: An expanding job description for Blimp-1/PRDM1 publication-title: Curr. Opin. Genet. Dev doi: 10.1016/j.gde.2009.05.005 contributor: fullname: Bikoff – volume: 76 start-page: 138 year: 2003 ident: 2020071306124035800_kfaa063-B75 article-title: Aryl hydrocarbon receptor 2 mediates 2,3,7,8-tetrachlorodibenzo-p-dioxin developmental toxicity in zebrafish publication-title: Toxicol. Sci doi: 10.1093/toxsci/kfg202 contributor: fullname: Prasch – volume: 135 start-page: 3149 year: 2008 ident: 2020071306124035800_kfaa063-B36 article-title: DLX3 is a crucial regulator of hair follicle differentiation and cycling publication-title: Development doi: 10.1242/dev.022202 contributor: fullname: Hwang – volume: 140 start-page: 136 year: 2015 ident: 2020071306124035800_kfaa063-B25 article-title: Prenatal polycyclic aromatic hydrocarbon (PAH) exposure, antioxidant levels and behavioral development of children ages 6–9 publication-title: Environ. Res doi: 10.1016/j.envres.2015.03.017 contributor: fullname: Genkinger – volume: 4 start-page: 1070 year: 2016 ident: 2020071306124035800_kfaa063-B51 article-title: RNA-seq workflow: Gene-level exploratory analysis and differential expression [version 2; referees: 2 approved] publication-title: F1000Res doi: 10.12688/f1000research.7035.2 contributor: fullname: Love – volume: 4 start-page: 45 year: 2016 ident: 2020071306124035800_kfaa063-B59 article-title: New trends in aryl hydrocarbon receptor biology publication-title: Front. Cell Dev. Biol doi: 10.3389/fcell.2016.00045 contributor: fullname: Mulero-Navarro – volume: 126 start-page: 117002 year: 2018 ident: 2020071306124035800_kfaa063-B23 article-title: Signaling events downstream of AHR activation that contribute to toxic responses: The functional role of an AHR-dependent long noncoding RNA (slincR) using the zebrafish model publication-title: Environ. Health Perspect doi: 10.1289/EHP3281 contributor: fullname: Garcia – volume: 12 start-page: 115 year: 2015 ident: 2020071306124035800_kfaa063-B35 article-title: Orchestrating high-throughput genomic analysis with bioconductor publication-title: Nat. Methods doi: 10.1038/nmeth.3252 contributor: fullname: Huber – volume-title: ggplot2: Elegant Graphics for Data Analysis year: 2016 ident: 2020071306124035800_kfaa063-B97 doi: 10.1007/978-3-319-24277-4 contributor: fullname: Wickham – volume: 36 start-page: 699 year: 2010 ident: 2020071306124035800_kfaa063-B90 article-title: Prenatal exposure to phthalate esters and PAHs and birth outcomes publication-title: Environ. Int doi: 10.1016/j.envint.2010.05.003 contributor: fullname: Suzuki – volume: 21 start-page: 3439 year: 2005 ident: 2020071306124035800_kfaa063-B18 article-title: BioMart and Bioconductor: A powerful link between biological databases and microarray data analysis publication-title: Bioinformatics doi: 10.1093/bioinformatics/bti525 contributor: fullname: Durinck – volume: 26 start-page: 573 year: 2005 ident: 2020071306124035800_kfaa063-B73 article-title: A summary of recent findings on birth outcomes and developmental effects of prenatal ETS, PAH, and pesticide exposures publication-title: Neurotoxicology doi: 10.1016/j.neuro.2004.07.007 contributor: fullname: Perera – volume: 3 start-page: 281 year: 2014 ident: 2020071306124035800_kfaa063-B86 article-title: SERPINE1: A molecular switch in the proliferation-migration dichotomy in wound-“activated” keratinocytes publication-title: Adv. Wound Care doi: 10.1089/wound.2013.0512 contributor: fullname: Simone – volume: 14 start-page: 417 year: 2017 ident: 2020071306124035800_kfaa063-B70 article-title: Salmon provides fast and bias-aware quantification of transcript expression publication-title: Nat. Methods doi: 10.1038/nmeth.4197 contributor: fullname: Patro – volume: 236 start-page: 1025 year: 2007 ident: 2020071306124035800_kfaa063-B17 article-title: Conditional targeted cell ablation in zebrafish: A new tool for regeneration studies publication-title: Dev. Dyn doi: 10.1002/dvdy.21100 contributor: fullname: Curado – volume: 124 start-page: e195 year: 2009 ident: 2020071306124035800_kfaa063-B72 article-title: Prenatal airborne polycyclic aromatic hydrocarbon exposure and child IQ at age 5 years publication-title: Pediatrics doi: 10.1542/peds.2008-3506 contributor: fullname: Perera – volume: 12 start-page: 55 year: 1996 ident: 2020071306124035800_kfaa063-B82 article-title: AH receptor signaling pathways publication-title: Annu. Rev. Cell Dev. Biol doi: 10.1146/annurev.cellbio.12.1.55 contributor: fullname: Schmidt – volume: 40 start-page: 1016 year: 2008 ident: 2020071306124035800_kfaa063-B99 article-title: Critical function of PRDM14 for the establishment of the germ cell lineage in mice publication-title: Nat. Genet doi: 10.1038/ng.186 contributor: fullname: Yamaji – volume: 13 start-page: 2498 year: 2003 ident: 2020071306124035800_kfaa063-B85 article-title: Cytoscape: A software environment for integrated models of biomolecular interaction networks publication-title: Genome Res doi: 10.1101/gr.1239303 contributor: fullname: Shannon – volume: 69 start-page: 257 year: 2006 ident: 2020071306124035800_kfaa063-B55 article-title: Aryl hydrocarbon receptor activation inhibits regenerative growth publication-title: Mol. Pharmacol doi: 10.1124/mol.105.018044 contributor: fullname: Mathew – volume: 25 start-page: 71 year: 1992 ident: 2020071306124035800_kfaa063-B67 article-title: Comparative developmental toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) publication-title: Chemosphere doi: 10.1016/0045-6535(92)90482-7 contributor: fullname: Olson – volume: 119 start-page: 229 year: 2006 ident: 2020071306124035800_kfaa063-B69 article-title: Prostaglandin E-2 synthesis and secretion: The role of PGE(2) synthases publication-title: Clin. Immunol doi: 10.1016/j.clim.2006.01.016 contributor: fullname: Park – volume: 143 start-page: 469 year: 2015 ident: 2020071306124035800_kfaa063-B39 article-title: AHR2-mediated transcriptomic responses underlying the synergistic cardiac developmental toxicity of PAHs publication-title: Toxicol. Sci doi: 10.1093/toxsci/kfu245 contributor: fullname: Jayasundara |
SSID | ssj0011609 |
Score | 2.4169009 |
Snippet | Abstract
The aryl hydrocarbon receptor (AHR) mediates developmental toxicity of several xenobiotic classes including polycyclic aromatic hydrocarbons. Using... The aryl hydrocarbon receptor (AHR) mediates developmental toxicity of several xenobiotic classes including polycyclic aromatic hydrocarbons. Using embryonic... |
SourceID | pubmedcentral crossref pubmed oup |
SourceType | Open Access Repository Aggregation Database Index Database Publisher |
StartPage | 46 |
SubjectTerms | Animals Developmental and Reproductive Toxicology Embryo, Nonmammalian Fluorenes - toxicity Larva Polycyclic Aromatic Hydrocarbons - toxicity Receptors, Aryl Hydrocarbon - metabolism Water Pollutants, Chemical - toxicity Zebrafish Zebrafish Proteins - metabolism |
Title | Aryl Hydrocarbon Receptor Mediates Larval Zebrafish Fin Duplication Following Exposure to Benzofluoranthenes |
URI | https://www.ncbi.nlm.nih.gov/pubmed/32384158 https://pubmed.ncbi.nlm.nih.gov/PMC7357178 |
Volume | 176 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwGLVKJyEkhKDcOi6yEBoPXbY0cS5-7GBdxSiqoBMTL5XT2Fu1KplCItr9Jn4kn2vHSTQug5fIci1XzTm1j7-bEXrtMkI5E8zifggHFBZSKwr6nhXJNEjp6XVdme88_uiPTsj7U--01fpRi1oq8mhvfvXLvJL_QRX6AFeZJfsPyJpJoQPagC88AWF43gjjQbZe9kbrGDYhlkWpNMbLKJU02_hfpIrsfZB3_yx7X6V_WMjqRcNF0ntXGK91bwhESL9Lg8Hh6jKV9kIpRw94cpWKZQEESWR9BB1pqFXsNF0t5mbV1JuoEedHmwjauBaUXxlMj_hCcWS8yDNWmWgPijMVLvBZegaqO47PWXKhQsAncKqXZn5Wt1PAobSMac3_lP9YW3rhMGX5trrXaY9XfTbVNpFyvVYXxjSIqVZfbcxU-7gqjn5th1DVs_J0BS8HGheCMVsvsc26278ffAttOQH1vDbaGhx_-nJsvFZ9fxNSZH6JKRLq7qs59vUMDRGkEiuN_mnG5tbEzvQ-uqdPKXigKPcAtXjSQbfHOg6jg3YmquL5ehdPqwS-b7t4B0-qWujrDrqrzMJYZbs9REtJWVyjLC4pi0vKYkVZbCiLgbK4RllsKItLyuI8xdcp-widDA-nb0eWvvDDmhOH5BYJhLCJC68IZKjNeD-kARVMRJQyIlgA8tYPWMwcEVLmcgdaPuMRLCrCCzkn7mPUTtKEP0U4nocxdyijtghJzGLqMBIJ6IpJDEP7XfSmRGB2qeq6zFQ8hjtTWM00Vl30CgD666AnCjYzzgUtDOI47KKgAagZIOu6Nz9JFueb-u6B6wX9INy-yRc_Q3eqP9tz1M6zgr8AmZxHLzU7fwJgWMrb |
link.rule.ids | 230,315,786,790,891,27955,27956 |
linkProvider | Library Specific Holdings |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Aryl+Hydrocarbon+Receptor+Mediates+Larval+Zebrafish+Fin+Duplication+Following+Exposure+to+Benzofluoranthenes&rft.jtitle=Toxicological+sciences&rft.au=Garland%2C+Michael+A&rft.au=Geier%2C+Mitra+C&rft.au=Bugel%2C+Sean+M&rft.au=Shankar%2C+Prarthana&rft.date=2020-07-01&rft.pub=Oxford+University+Press&rft.issn=1096-6080&rft.eissn=1096-0929&rft.volume=176&rft.issue=1&rft.spage=46&rft.epage=64&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfaa063&rft.externalDocID=10.1093%2Ftoxsci%2Fkfaa063 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1096-6080&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1096-6080&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1096-6080&client=summon |