Trypanosoma cruzi: The effects of zinc supplementation during experimental infection

It is well recognized that zinc is an essential trace element, influencing growth and affecting the development and integrity of the immune system. The use of oligoelements as zinc can be considered a tool in modulating the effectiveness of the immune response. In this work zinc was daily and orally...

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Published inExperimental parasitology Vol. 118; no. 4; pp. 549 - 554
Main Authors Brazão, Vânia, Filipin, Marina Del Vecchio, Caetano, Leony Cristina, Toldo, Miriam Paula Alonso, Caetano, Luana Naiara, Prado, José Clóvis do
Format Journal Article
LanguageEnglish
Published San Diego, CA Elsevier Inc 01.04.2008
Elsevier
Subjects
Administration, Oral
Animals
Biological and medical sciences
Cell Count
Chagas Disease - drug therapy
Chagas Disease - immunology
Chagas Disease - parasitology
Cytokines - biosynthesis
Cytokines - drug effects
Fundamental and applied biological sciences. Psychology
Interferon gamma (IFN-γ)
Interferon-gamma - biosynthesis
Life cycle. Host-agent relationship. Pathogenesis
Macrophages, Peritoneal - cytology
Macrophages, Peritoneal - drug effects
Male
Nitric oxide (NO)
Nitric Oxide - biosynthesis
Parasitemia - drug therapy
Parasitemia - immunology
Parasitemia - parasitology
Peritoneal macrophages
Protozoa
Rats
Rats, Wistar
Trypanosoma cruzi
Trypanosoma cruzi - drug effects
Trypanosoma cruzi - immunology
Zinc
Zinc - administration & dosage
Interferon gamma (IFN-γ)
Zinc
Nitric oxide (NO)
Peritoneal macrophages
Trypanosoma cruzi
Kinetoplastida
Infection
Protozoa
Parasite
Supplementation
Experimental study
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Abstract It is well recognized that zinc is an essential trace element, influencing growth and affecting the development and integrity of the immune system. The use of oligoelements as zinc can be considered a tool in modulating the effectiveness of the immune response. In this work zinc was daily and orally supplied in male Wistar rats infected with the Y strain of Trypanosoma cruzi. Parasitemia was evaluated and a significant reduction on blood parasites was observed. In order to check some immunological parameters peritoneal macrophages were counted revealing higher percentages for zinc supplied group. Consequently enhanced concentrations of IFN-γ was found and for the first time NO was evaluated in T. cruzi infected animals under the influence of zinc therapy, revealing enhanced concentrations when compared to unsupplied counterparts. We conclude that zinc is able to up-regulate the host’s immune response against parasite replication.
AbstractList It is well recognized that zinc is an essential trace element, influencing growth and affecting the development and integrity of the immune system. The use of oligoelements as zinc can be considered a tool in modulating the effectiveness of the immune response. In this work zinc was daily and orally supplied in male Wistar rats infected with the Y strain of Trypanosoma cruzi. Parasitemia was evaluated and a significant reduction on blood parasites was observed. In order to check some immunological parameters peritoneal macrophages were counted revealing higher percentages for zinc supplied group. Consequently enhanced concentrations of IFN-gamma was found and for the first time NO was evaluated in T. cruzi infected animals under the influence of zinc therapy, revealing enhanced concentrations when compared to unsupplied counterparts. We conclude that zinc is able to up-regulate the host's immune response against parasite replication.
It is well recognized that zinc is an essential trace element, influencing growth and affecting the development and integrity of the immune system. The use of oligoelements as zinc can be considered a tool in modulating the effectiveness of the immune response. In this work zinc was daily and orally supplied in male Wistar rats infected with the Y strain of Trypanosoma cruzi. Parasitemia was evaluated and a significant reduction on blood parasites was observed. In order to check some immunological parameters peritoneal macrophages were counted revealing higher percentages for zinc supplied group. Consequently enhanced concentrations of IFN-γ was found and for the first time NO was evaluated in T. cruzi infected animals under the influence of zinc therapy, revealing enhanced concentrations when compared to unsupplied counterparts. We conclude that zinc is able to up-regulate the host’s immune response against parasite replication.
Author Brazão, Vânia
Filipin, Marina Del Vecchio
Caetano, Luana Naiara
Caetano, Leony Cristina
Prado, José Clóvis do
Toldo, Miriam Paula Alonso
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  givenname: Vânia
  surname: Brazão
  fullname: Brazão, Vânia
  email: vbrazao@fcfrp.usp.br
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  givenname: Marina Del Vecchio
  surname: Filipin
  fullname: Filipin, Marina Del Vecchio
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  surname: Caetano
  fullname: Caetano, Leony Cristina
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  fullname: Toldo, Miriam Paula Alonso
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  givenname: José Clóvis do
  surname: Prado
  fullname: Prado, José Clóvis do
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Issue 4
Keywords Interferon gamma (IFN-γ)
Zinc
Nitric oxide (NO)
Peritoneal macrophages
Trypanosoma cruzi
Kinetoplastida
Infection
Protozoa
Parasite
Supplementation
Experimental study
Language English
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Snippet It is well recognized that zinc is an essential trace element, influencing growth and affecting the development and integrity of the immune system. The use of...
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SubjectTerms Administration, Oral
Animals
Biological and medical sciences
Cell Count
Chagas Disease - drug therapy
Chagas Disease - immunology
Chagas Disease - parasitology
Cytokines - biosynthesis
Cytokines - drug effects
Fundamental and applied biological sciences. Psychology
Interferon gamma (IFN-γ)
Interferon-gamma - biosynthesis
Life cycle. Host-agent relationship. Pathogenesis
Macrophages, Peritoneal - cytology
Macrophages, Peritoneal - drug effects
Male
Nitric oxide (NO)
Nitric Oxide - biosynthesis
Parasitemia - drug therapy
Parasitemia - immunology
Parasitemia - parasitology
Peritoneal macrophages
Protozoa
Rats
Rats, Wistar
Trypanosoma cruzi
Trypanosoma cruzi - drug effects
Trypanosoma cruzi - immunology
Zinc
Zinc - administration & dosage
Title Trypanosoma cruzi: The effects of zinc supplementation during experimental infection
URI https://dx.doi.org/10.1016/j.exppara.2007.11.008
https://www.ncbi.nlm.nih.gov/pubmed/18177642
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Volume 118
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