Effect of a 12-Week Walking Program Monitored by Global Physical Capacity Score (GPCS) on Circulating Cell-Free mtDNA and DNase Activity in Patients with Irritable Bowel Syndrome

• Published in: International journal of molecular sciences Vol. 25; no. 8; p. 4293
• Main Authors: Chimienti, Guglielmina, Russo, Francesco, Bianco, Antonella, Maqoud, Fatima, De Virgilio, Caterina, Galeano, Grazia, Orlando, Antonella, Riezzo, Giuseppe, D’Attoma, Benedetta, Ignazzi, Antonia, Linsalata, Michele, Prospero, Laura, Franco, Isabella, Bagnato, Claudia Beatrice, Curci, Ritanna, Coletta, Sergio
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 12.04.2024
• Subjects: Adult; Aerobics; Autoimmune diseases; Care and treatment; Cell division; Cell-Free Nucleic Acids - genetics; Cytokines; Deoxyribonucleases - genetics; Deoxyribonucleases - metabolism; Disease; DNA, Mitochondrial - genetics; Enzymes; Exercise; Exercise - physiology; Female; Humans; Immunology; Inflammation; Instrument industry; Irritable bowel syndrome; Irritable Bowel Syndrome - genetics; Irritable Bowel Syndrome - metabolism; Male; Middle Aged; Mitochondria; Mitochondrial DNA; Oxidative stress; Pathogenesis; Patients; Physical fitness; Plasma; Polymorphism, Single Nucleotide; Walking; United States; Global Physical Capacity core; cf-mtDNA; exercise; DNase activity; IBS; inflammation

Irritable bowel syndrome (IBS) involves low-grade mucosal inflammation. Among the various approaches capable of managing the symptoms, physical activity is still under investigation. Despite its benefits, it promotes oxidative stress and inflammation. Mitochondria impacts gut disorders by releasing...