Next-generation sequencing reveals heterogeneous genetic alterations in key signaling pathways of mismatch repair deficient colorectal carcinomas - Wang, Jing; Li, Ruiyu; He, Yangzhige; Yi, Yuting; Wu, Huanwen; Liang, Zhiyong (Modern pathology, 2020)
Keywords: 1-Phosphatidylinositol 3-kinase; 692/308/2056; 692/699/67/1504/1885; Adenomatous polyposis coli; Biomarkers, Tumor - genetics; BRCA2 protein; Clinical Decision-Making; Coexistence; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - genetics; Colorectal Neoplasms - pathology; Colorectal Neoplasms - therapy; Divergence; DNA damage; DNA Methylation; DNA Mismatch Repair; DNA Mutational Analysis; DNA repair; Gene Fusion; Genetic disorders; Genetic Heterogeneity; Genetic Predisposition to Disease; High-Throughput Nucleotide Sequencing; Humans; Kinases; Laboratory Medicine; Medicine; Medicine & Public Health; Microsatellite instability; Mismatch repair; MLH1 protein; Mutation; MutL Protein Homolog 1 - genetics; Next-generation sequencing; p53 Protein; Pathology; Phenotype; Point mutation; Polyps; Precision Medicine; Predictive Value of Tests; Promoter Regions, Genetic; Protein-tyrosine kinase receptors; Retrospective Studies; Signal transduction; Signal Transduction - genetics; Tumors; Wnt protein