FK506-Binding Protein 13 Expression Is Upregulated in Interstitial Lung Disease and Correlated with Clinical Severity. A Potentially Protective Role

• Published in: American journal of respiratory cell and molecular biology Vol. 64; no. 2; pp. 235 - 246
• Main Authors: Tat, Victor, Ayaub, Ehab A., Ayoub, Anmar, Vierhout, Megan, Naiel, Safaa, Padwal, Manreet K., Abed, Soumeya, Mekhael, Olivia, Tandon, Karun, Revill, Spencer D., Yousof, Tamana, Bellaye, Pierre-Simon, Kolb, Philipp S., Dvorkin-Gheva, Anna, Naqvi, Asghar, Cutz, Jean-Claude, Hambly, Nathan, Kato, Jiro, Vaughan, Martha, Moss, Joel, Kolb, Martin R. J., Ask, Kjetil
• Format: Journal Article
• Language: English
• Published: United States American Thoracic Society 01.02.2021
• Subjects: Animals; Biomarkers; Biomarkers - metabolism; Biopsy; Biopsy - methods; Bleomycin; Bleomycin - adverse effects; Cytokines - metabolism; Dyspnea; Endoplasmic reticulum; Endoplasmic Reticulum - drug effects; Endoplasmic Reticulum - metabolism; Female; Fibrosis; Gene expression; Humans; Idiopathic Pulmonary Fibrosis - metabolism; Idiopathic Pulmonary Fibrosis - pathology; Inflammation; Inflammation - metabolism; Inflammation - pathology; Lung; Lung diseases; Lung Diseases, Interstitial - metabolism; Lung Diseases, Interstitial - pathology; Male; Mice; Mice, Inbred C57BL; Middle Aged; Original Research; Proteins; Pulmonary fibrosis; Respiration; Severity of Illness Index; Tacrolimus; Tacrolimus Binding Proteins - metabolism; Tacrolimus-binding protein; Up-Regulation - drug effects; Up-Regulation - physiology; unfolded protein response; inflammation; interstitial lung disease; FKBP13; endoplasmic reticulum stress
• ISSN: 1044-1549; 1535-4989; 1535-4989
• DOI: 10.1165/rcmb.2020-0121OC

Pulmonary fibrosis is a progressive lung disease characterized by myofibroblast accumulation and excessive extracellular matrix deposition. We sought to investigate the role of FKBP13 (13-kD FK506-binding protein), an endoplasmic reticulum-resident molecular chaperone, in various forms of pulmonary...