Quantitative analysis of toxin extracts from various tissues of wild and cultured puffer fish by an electrophysiological method

• Published in: Toxicon (Oxford) Vol. 51; no. 4; pp. 606 - 614
• Main Authors: Sasaki, Keita, Takayama, Yasunori, Tahara, Tatsuo, Anraku, Kensaku, Ito, Yushi, Akaike, Norio
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 15.03.2008; Elsevier Science
• Subjects: Animal poisons toxicology. Antivenoms; Animals; Biological and medical sciences; Electrophysiology - methods; Female; Food poisoning; Medical sciences; Neurons - drug effects; Neurons - physiology; Puffer toxin; Rats; Single CA1 neuron; Sodium channel; Sodium Channels - metabolism; Tetraodontiformes - metabolism; Tetrodotoxin; Tetrodotoxin - analysis; Tissue Extracts - chemistry; Toxicology; Wild and cultured fish; Tetrodotoxin; Wild and cultured fish; Sodium channel; Single CA1 neuron; Puffer toxin; Food poisoning; Rat; Toxicity; Rodentia; Electrophysiology; Animal origin; Ionic channel; Extract; In vitro; Tissue; Toxin; Vertebrata; Mammalia; Neuron; Animal; Pisces; Sodium ion; Digestive diseases; Quantitative analysis

We observed the effects of the toxin extracted from various tissues of wild and cultured puffer fish on voltage-dependent sodium current ( I Na) using single rat CA1 neurons, and compared the results with that of tetrodotoxin (TTX). Toxin extracts from wild puffer fish inhibited I Na in a dilution-d...