Ubiquinone biosynthesis by the microsomal fraction from rat liver

• Published in: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS Vol. 926; no. 1; pp. 70 - 78
• Main Authors: Kalén, A., Norling, B., Appelkvist, E.L., Dallner, G.
• Format: Journal Article Publication
• Language: English
• Published: Amsterdam Elsevier B.V 08.10.1987; Elsevier; North-Holland
• Subjects: Analytical, structural and metabolic biochemistry; Animals; Biological and medical sciences; Cattle; Cell Fractionation; Fundamental and applied biological sciences. Psychology; Lipids; Liver - metabolism; Male; Mevalonate incorporation; Microsomes, Liver - metabolism; Mitochondria, Heart - metabolism; Other biological molecules; Rat liver; Rats; Rats, Inbred Strains; Subcellular distribution; Subcellular Fractions - metabolism; Submitochondrial Particles - metabolism; Ubiquinone - biosynthesis; Ubiquinone - isolation & purification; Ubiquinone synthesis; Ubiquinone synthesis; Rat liver; Subcellular distribution; Mevalonate incorporation; Vesicle; Rat; Liver; Rodentia; Lysosome; HPLC chromatography; Lipids; Biosynthesis; Microsome; Golgi apparatus; Absorption spectrometry; Vertebrata; Mitochondria; Mammalia; Ubiquinone; Distribution; Endoplasmic reticulum

The distribution and biosynthesis of ubiquinone were investigated in vivo in rats and using liver slices. In addition to mitochondria, Golgi vesicles and lysosomes also contain large amounts of this lipid, and even the plasma membrane, peroxisomes and microsomes demonstrate easily measurable amounts...