In vivo cholinergic basal forebrain degeneration and cognition in Parkinson's disease: Imaging results from the COPPADIS study

• Published in: Parkinsonism & related disorders Vol. 88; pp. 68 - 75
• Main Authors: Grothe, Michel J., Labrador-Espinosa, Miguel A., Jesús, Silvia, Macías-García, Daniel, Adarmes-Gómez, Astrid, Carrillo, Fátima, Camacho, Elena Iglesias, Franco-Rosado, Pablo, Lora, Florinda Roldán, Martín-Rodríguez, Juan Francisco, Barberá, Miquel Aguilar, Pastor, Pau, Arroyo, Sonia Escalante, Vila, Berta Solano, Foraster, Anna Cots, Martínez, Javier Ruiz, Padilla, Francisco Carrillo, Morlans, Mercedes Pueyo, Aramburu, Isabel González, Ceberio, Jon Infante, Vara, Jorge Hernández, de Fábregues-Boixar, Oriol, de Deus Fonticoba, Teresa, Pascual-Sedano, Berta, Kulisevsky, Jaime, Martínez-Martín, Pablo, Santos-García, Diego, Mir, Pablo
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.07.2021
• Subjects: Aged; Basal Forebrain - diagnostic imaging; Basal Forebrain - pathology; Cognitive Dysfunction - etiology; Cognitive Dysfunction - physiopathology; Cohort Studies; Diffusion; Diffusion Tensor Imaging; DTI; Female; Hippocampus - diagnostic imaging; Hippocampus - pathology; Humans; Magnetic Resonance Imaging; Male; Middle Aged; MRI; Multimodal Imaging; Neuroimaging; Neuropsychological Tests; Nucleus basalis Meynert; Parkinson Disease - complications; Parkinson Disease - diagnostic imaging; Parkinson Disease - pathology; Parkinson Disease - physiopathology; Parkinson's disease; Substantia innominata; DTI; Nucleus basalis Meynert; Parkinson's disease; Substantia innominata; Diffusion; MRI

We aimed to assess associations between multimodal neuroimaging measures of cholinergic basal forebrain (CBF) integrity and cognition in Parkinson's disease (PD) without dementia. The study included a total of 180 non-demented PD patients and 45 healthy controls, who underwent structural MRI ac...