MicroRNA regulation of nonmuscle myosin light chain kinase expression in human lung endothelium

• Published in: American journal of respiratory cell and molecular biology Vol. 49; no. 1; pp. 58 - 66
• Main Authors: Adyshev, Djanybek M, Moldobaeva, Nurgul, Mapes, Brandon, Elangovan, Venkate, Garcia, Joe G N
• Format: Journal Article
• Language: English
• Published: United States American Thoracic Society 01.07.2013
• Subjects: 3' Untranslated Regions; Acute Lung Injury - drug therapy; Acute Lung Injury - metabolism; Acute Lung Injury - pathology; Anti-Inflammatory Agents, Non-Steroidal - pharmacology; Biomimetics; Calcium-Binding Proteins - genetics; Calcium-Binding Proteins - metabolism; Capillary Permeability; Cell Line; Endothelium - enzymology; Endothelium - pathology; Gene Expression Regulation; Genes, Reporter; Humans; Lipopolysaccharides - pharmacology; Luciferases - metabolism; Lung - enzymology; Lung - pathology; MicroRNAs - antagonists & inhibitors; MicroRNAs - genetics; MicroRNAs - metabolism; Myosin-Light-Chain Kinase - genetics; Myosin-Light-Chain Kinase - metabolism; Pneumonia - metabolism; Pneumonia - pathology; Pulmonary Artery - metabolism; Pulmonary Artery - pathology; Stress, Mechanical; Transcription, Genetic; Transfection; Tumor Necrosis Factor-alpha - metabolism; Tumor Necrosis Factor-alpha - pharmacology

Increased lung vascular permeability, the consequence of endothelial cell (EC) barrier dysfunction, is a cardinal feature of inflammatory conditions such as acute lung injury and sepsis and leads to lethal physiological dysfunction characterized by alveolar flooding, hypoxemia, and pulmonary edema....