Subcellular compartment targeting of layered double hydroxide nanoparticles

• Published in: Journal of controlled release Vol. 130; no. 1; pp. 86 - 94
• Main Authors: Xu, Zhi Ping, Niebert, Marcus, Porazik, Katharina, Walker, Tara L., Cooper, Helen M., Middelberg, Anton P.J., Gray, Peter P., Bartlett, Perry F., Lu, Gao Qing (Max)
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 25.08.2008; Elsevier
• Subjects: Aluminum Hydroxide - chemistry; Animals; Biological and medical sciences; Cell Survival - drug effects; Cellular uptake; CHO Cells; Clathrin - metabolism; Clathrin-mediated endocytosis; Cricetinae; Cricetulus; Drug Carriers - adverse effects; Drug Carriers - chemistry; Drug-Related Side Effects and Adverse Reactions; Endocytosis - drug effects; Fluorescein-5-isothiocyanate - chemistry; Gene Transfer Techniques; General pharmacology; Hydroxides - adverse effects; Hydroxides - chemistry; Layered double hydroxides; Magnesium Hydroxide - chemistry; Medical sciences; Mice; Microscopy, Confocal; Morphology; Nanoparticles - adverse effects; Nanoparticles - chemistry; NIH 3T3 Cells; Particle Size; Pharmaceutical Preparations - administration & dosage; Pharmaceutical Preparations - chemistry; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Subcellular compartment targeting; Subcellular Fractions - metabolism; Cellular uptake; Clathrin-mediated endocytosis; Subcellular compartment targeting; Morphology; Layered double hydroxides; Microparticle; Target; Pharmaceutical technology; Targeting; Nanoparticle; Layered double hydroxides;Cellular uptake;Clathrin-mediated endocytosis;Morphology;Subcellular compartment targeting

Current investigations show that layered double hydroxide (LDH) nanoparticles have high potential as effective non-viral agents for cellular drug delivery due to their low cytotoxicity, good biocompatibility, high drug loading, control of particle size and shape, targeted delivery and drug release c...