Increased IL-17A secreting CD4+ T cells, serum IL-17 levels and exhaled nitric oxide are correlated with childhood asthma severity

• Published in: Clinical and experimental allergy Vol. 43; no. 9; pp. 1018 - 1026
• Main Authors: Chien, J.-W., Lin, C.-Y., Yang, K. D., Lin, C.-H., Kao, J.-K., Tsai, Y.-G.
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.09.2013; Wiley Subscription Services, Inc
• Subjects: Adolescent; Asthma - immunology; Asthma - metabolism; Asthma - physiopathology; C-ACT; CD4-Positive T-Lymphocytes - immunology; CD4-Positive T-Lymphocytes - metabolism; Child; Child, Preschool; Exhalation; Female; Humans; IL-17; Interleukin-17 - blood; Interleukin-17 - metabolism; Male; nitric oxide; Nitric Oxide - metabolism; Nitric Oxide Synthase Type II - metabolism; Respiratory Function Tests; Severity of Illness Index; Sputum - cytology; Sputum - immunology; Sputum - metabolism; Th17 Cells - immunology; Th17 Cells - metabolism; C-ACT; nitric oxide; IL-17

Summary Background Measuring fractional exhaled nitric oxide (FeNO) is a simple and non‐invasive method for assessing airway inflammation. IL‐17 plays an important role in T cell‐dependent inflammatory response that occurs in allergic asthma, it could act as a potent activator of inducible nitric ox...