P2Y12 Receptors Play a Significant Role in the Development of Platelet Microaggregation in Patients with Diabetes

• Published in: The journal of clinical endocrinology and metabolism Vol. 90; no. 2; pp. 920 - 927
• Main Authors: Matsuno, Hiroyuki, Tokuda, Haruhiko, Ishisaki, Akira, Zhou, Yuan, Kitajima, Yasuo, Kozawa, Osamu
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Oxford University Press 01.02.2005; Copyright by The Endocrine Society; Endocrine Society
• Subjects: Adenosine Diphosphate - pharmacology; Adenosine Monophosphate - analogs & derivatives; Adenosine Monophosphate - pharmacology; Aged; Aspirin; Biological and medical sciences; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - physiopathology; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Female; Fundamental and applied biological sciences. Psychology; Humans; Ischemia; Male; Mechanical stimuli; Medical sciences; Membrane Proteins - drug effects; Membrane Proteins - physiology; Middle Aged; Piperazines - pharmacology; Piperidines - pharmacology; Platelet Aggregation - drug effects; Platelet Aggregation - physiology; Platelets; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2 - drug effects; Receptors, Purinergic P2 - physiology; Receptors, Purinergic P2Y12; Reference Values; Shear stress; Ticlopidine; Vertebrates: endocrinology; Endocrinopathy; Human; P2Y12 purinergic receptor; Platelet; Diabetes mellitus; Development; Endocrinology

Ninety-eight diabetic patients (type 2) were studied together with 24 healthy normotensive controls. Microaggregates (particle scale, <25 μm) of platelets were detected by a laser scattering system. Microaggregates in the control group showed a time-dependent reversible change; however, they exis...