New Treatment Strategies for Malignant Gliomas

Although survival in patients with malignant gliomas remains limited, there is renewed optimism with the emergence of novel treatment strategies. Cytotoxic agents such as temozolomide and CPT‐11 have shown promising clinical activity. Biological treatments for brain tumors, including antisense oligo...

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Published inThe oncologist (Dayton, Ohio) Vol. 4; no. 3; pp. 209 - 224
Main Authors Avgeropoulos, Nicholas G., Batchelor, Tracy T.
Format Journal Article
LanguageEnglish
Published Durham, NC, USA AlphaMed Press 01.06.1999
Subjects
Angiogenesis
Antineoplastic Agents - therapeutic use
Antisense
Biological Therapy - trends
Blood-Brain Barrier
Brain Neoplasms - therapy
Chemotherapy
Clinical trials
Cytokine
Gene therapy
Genetic Therapy
Glioma
Glioma - therapy
Humans
Immunotherapy
Prognosis
Quality of Life
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Abstract Although survival in patients with malignant gliomas remains limited, there is renewed optimism with the emergence of novel treatment strategies. Cytotoxic agents such as temozolomide and CPT‐11 have shown promising clinical activity. Biological treatments for brain tumors, including antisense oligonucleotides, gene therapy, and angiogenesis inhibitors, are also being evaluated in clinical trials. Delivery strategies have been developed to overcome challenges presented by the blood‐brain barrier. These noteworthy treatments, alone or in combination, may ultimately prolong survival and enhance quality of life in this group of patients.
AbstractList Although survival in patients with malignant gliomas remains limited, there is renewed optimism with the emergence of novel treatment strategies. Cytotoxic agents such as temozolomide and CPT-11 have shown promising clinical activity. Biological treatments for brain tumors, including antisense oligonucleotides, gene therapy, and angiogenesis inhibitors, are also being evaluated in clinical trials. Delivery strategies have been developed to overcome challenges presented by the blood-brain barrier. These noteworthy treatments, alone or in combination, may ultimately prolong survival and enhance quality of life in this group of patients.
Abstract Although survival in patients with malignant gliomas remains limited, there is renewed optimism with the emergence of novel treatment strategies. Cytotoxic agents such as temozolomide and CPT-11 have shown promising clinical activity. Biological treatments for brain tumors, including antisense oligonucleotides, gene therapy, and angiogenesis inhibitors, are also being evaluated in clinical trials. Delivery strategies have been developed to overcome challenges presented by the blood-brain barrier. These noteworthy treatments, alone or in combination, may ultimately prolong survival and enhance quality of life in this group of patients.
Author Batchelor, Tracy T.
Avgeropoulos, Nicholas G.
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SSID ssj0015932
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SecondaryResourceType review_article
Snippet Although survival in patients with malignant gliomas remains limited, there is renewed optimism with the emergence of novel treatment strategies. Cytotoxic...
Abstract Although survival in patients with malignant gliomas remains limited, there is renewed optimism with the emergence of novel treatment strategies....
SourceID proquest
crossref
pubmed
wiley
SourceType Aggregation Database
Index Database
Publisher
StartPage 209
SubjectTerms Angiogenesis
Antineoplastic Agents - therapeutic use
Antisense
Biological Therapy - trends
Blood-Brain Barrier
Brain Neoplasms - therapy
Chemotherapy
Clinical trials
Cytokine
Gene therapy
Genetic Therapy
Glioma
Glioma - therapy
Humans
Immunotherapy
Prognosis
Quality of Life
Title New Treatment Strategies for Malignant Gliomas
URI https://onlinelibrary.wiley.com/doi/abs/10.1634%2Ftheoncologist.4-3-209
https://www.ncbi.nlm.nih.gov/pubmed/10394589
https://search.proquest.com/docview/69868197
Volume 4
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