New Treatment Strategies for Malignant Gliomas
Although survival in patients with malignant gliomas remains limited, there is renewed optimism with the emergence of novel treatment strategies. Cytotoxic agents such as temozolomide and CPT‐11 have shown promising clinical activity. Biological treatments for brain tumors, including antisense oligo...
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Published in | The oncologist (Dayton, Ohio) Vol. 4; no. 3; pp. 209 - 224 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
Durham, NC, USA
AlphaMed Press
01.06.1999
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Abstract | Although survival in patients with malignant gliomas remains limited, there is renewed optimism with the emergence of novel treatment strategies. Cytotoxic agents such as temozolomide and CPT‐11 have shown promising clinical activity. Biological treatments for brain tumors, including antisense oligonucleotides, gene therapy, and angiogenesis inhibitors, are also being evaluated in clinical trials. Delivery strategies have been developed to overcome challenges presented by the blood‐brain barrier. These noteworthy treatments, alone or in combination, may ultimately prolong survival and enhance quality of life in this group of patients. |
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AbstractList | Although survival in patients with malignant gliomas remains limited, there is renewed optimism with the emergence of novel treatment strategies. Cytotoxic agents such as temozolomide and CPT-11 have shown promising clinical activity. Biological treatments for brain tumors, including antisense oligonucleotides, gene therapy, and angiogenesis inhibitors, are also being evaluated in clinical trials. Delivery strategies have been developed to overcome challenges presented by the blood-brain barrier. These noteworthy treatments, alone or in combination, may ultimately prolong survival and enhance quality of life in this group of patients. Abstract Although survival in patients with malignant gliomas remains limited, there is renewed optimism with the emergence of novel treatment strategies. Cytotoxic agents such as temozolomide and CPT-11 have shown promising clinical activity. Biological treatments for brain tumors, including antisense oligonucleotides, gene therapy, and angiogenesis inhibitors, are also being evaluated in clinical trials. Delivery strategies have been developed to overcome challenges presented by the blood-brain barrier. These noteworthy treatments, alone or in combination, may ultimately prolong survival and enhance quality of life in this group of patients. |
Author | Batchelor, Tracy T. Avgeropoulos, Nicholas G. |
Author_xml | – sequence: 1 givenname: Nicholas G. surname: Avgeropoulos fullname: Avgeropoulos, Nicholas G. – sequence: 2 givenname: Tracy T. surname: Batchelor fullname: Batchelor, Tracy T. email: batchelor@helix.mgh.harvard.edu |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/10394589$$D View this record in MEDLINE/PubMed |
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Snippet | Although survival in patients with malignant gliomas remains limited, there is renewed optimism with the emergence of novel treatment strategies. Cytotoxic... Abstract Although survival in patients with malignant gliomas remains limited, there is renewed optimism with the emergence of novel treatment strategies.... |
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SubjectTerms | Angiogenesis Antineoplastic Agents - therapeutic use Antisense Biological Therapy - trends Blood-Brain Barrier Brain Neoplasms - therapy Chemotherapy Clinical trials Cytokine Gene therapy Genetic Therapy Glioma Glioma - therapy Humans Immunotherapy Prognosis Quality of Life |
Title | New Treatment Strategies for Malignant Gliomas |
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