New Treatment Strategies for Malignant Gliomas

Although survival in patients with malignant gliomas remains limited, there is renewed optimism with the emergence of novel treatment strategies. Cytotoxic agents such as temozolomide and CPT‐11 have shown promising clinical activity. Biological treatments for brain tumors, including antisense oligo...

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Bibliographic Details
Published inThe oncologist (Dayton, Ohio) Vol. 4; no. 3; pp. 209 - 224
Main Authors Avgeropoulos, Nicholas G., Batchelor, Tracy T.
Format Journal Article
LanguageEnglish
Published Durham, NC, USA AlphaMed Press 01.06.1999
Subjects
Angiogenesis
Antineoplastic Agents - therapeutic use
Antisense
Biological Therapy - trends
Blood-Brain Barrier
Brain Neoplasms - therapy
Chemotherapy
Clinical trials
Cytokine
Gene therapy
Genetic Therapy
Glioma
Glioma - therapy
Humans
Immunotherapy
Prognosis
Quality of Life
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Summary:Although survival in patients with malignant gliomas remains limited, there is renewed optimism with the emergence of novel treatment strategies. Cytotoxic agents such as temozolomide and CPT‐11 have shown promising clinical activity. Biological treatments for brain tumors, including antisense oligonucleotides, gene therapy, and angiogenesis inhibitors, are also being evaluated in clinical trials. Delivery strategies have been developed to overcome challenges presented by the blood‐brain barrier. These noteworthy treatments, alone or in combination, may ultimately prolong survival and enhance quality of life in this group of patients.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1083-7159
1549-490X
DOI:10.1634/theoncologist.4-3-209