Evaluation of the efficacy of low-level light therapy using 1072 nm infrared light for the treatment of herpes simplex labialis

Summary Background Recent research has shown that low‐level light therapy (LLLT) using 1072 nm infrared light is effective in reducing the duration of herpes simplex labialis (HSL) episodes and enhancing the healing process. Methods This was a prospective, randomized, placebo‐controlled, clinical tr...

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Published in	Clinical and experimental dermatology Vol. 38; no. 7; pp. 713 - 718
Main Authors	Dougal, G., Lee, S. Y.
Format	Journal Article
Language	English
Published	England Blackwell Publishing Ltd 01.10.2013 Oxford University Press
Subjects	Adult Aged Clinical trials Female Herpes Labialis - pathology Herpes Labialis - therapy Humans Infrared Rays - therapeutic use Male Middle Aged Phototherapy - instrumentation Phototherapy - methods Prospective Studies Wound Healing - radiation effects Young Adult
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Abstract	Summary Background Recent research has shown that low‐level light therapy (LLLT) using 1072 nm infrared light is effective in reducing the duration of herpes simplex labialis (HSL) episodes and enhancing the healing process. Methods This was a prospective, randomized, placebo‐controlled, clinical trial to evaluate the efficacy of a 1072 nm light‐emitting diode device for the treatment of HSL. In total, 87 patients with recurrent HSL were recruited and randomly divided into two groups. Subjects received a 3‐min treatment with either 1072 nm infrared light therapy or placebo (sham) light therapy three times/day for 2 days. The devices used for both groups were identical in appearance and could not be differentiated by volunteers or researchers, and 1072 nm light is invisible to the human eye. The primary endpoint was healing time, which was taken as the time for the HSL lesions to resolve fully and for the underlying skin to become completely re‐epithelialized, and the secondary endpoint was lesion crusting. Results The median time to healing for the active group was 129 h, compared with 177 h for the control group, which was significant (P = 0.01). There was no difference between the two groups for median time to lesion crusting (P = 0.66). Conclusions Compared with placebo treatment, the treatment of HSL lesions with 1072 nm infrared light significantly reduced healing time.
AbstractList	Summary Background Recent research has shown that low‐level light therapy (LLLT) using 1072 nm infrared light is effective in reducing the duration of herpes simplex labialis (HSL) episodes and enhancing the healing process. Methods This was a prospective, randomized, placebo‐controlled, clinical trial to evaluate the efficacy of a 1072 nm light‐emitting diode device for the treatment of HSL. In total, 87 patients with recurrent HSL were recruited and randomly divided into two groups. Subjects received a 3‐min treatment with either 1072 nm infrared light therapy or placebo (sham) light therapy three times/day for 2 days. The devices used for both groups were identical in appearance and could not be differentiated by volunteers or researchers, and 1072 nm light is invisible to the human eye. The primary endpoint was healing time, which was taken as the time for the HSL lesions to resolve fully and for the underlying skin to become completely re‐epithelialized, and the secondary endpoint was lesion crusting. Results The median time to healing for the active group was 129 h, compared with 177 h for the control group, which was significant (P = 0.01). There was no difference between the two groups for median time to lesion crusting (P = 0.66). Conclusions Compared with placebo treatment, the treatment of HSL lesions with 1072 nm infrared light significantly reduced healing time. Summary Background Recent research has shown that low-level light therapy (LLLT) using 1072 nm infrared light is effective in reducing the duration of herpes simplex labialis (HSL) episodes and enhancing the healing process. Methods This was a prospective, randomized, placebo-controlled, clinical trial to evaluate the efficacy of a 1072 nm light-emitting diode device for the treatment of HSL. In total, 87 patients with recurrent HSL were recruited and randomly divided into two groups. Subjects received a 3-min treatment with either 1072 nm infrared light therapy or placebo (sham) light therapy three times/day for 2 days. The devices used for both groups were identical in appearance and could not be differentiated by volunteers or researchers, and 1072 nm light is invisible to the human eye. The primary endpoint was healing time, which was taken as the time for the HSL lesions to resolve fully and for the underlying skin to become completely re-epithelialized, and the secondary endpoint was lesion crusting. Results The median time to healing for the active group was 129 h, compared with 177 h for the control group, which was significant (P = 0.01). There was no difference between the two groups for median time to lesion crusting (P = 0.66). Conclusions Compared with placebo treatment, the treatment of HSL lesions with 1072 nm infrared light significantly reduced healing time. [PUBLICATION ABSTRACT] Recent research has shown that low-level light therapy (LLLT) using 1072 nm infrared light is effective in reducing the duration of herpes simplex labialis (HSL) episodes and enhancing the healing process. This was a prospective, randomized, placebo-controlled, clinical trial to evaluate the efficacy of a 1072 nm light-emitting diode device for the treatment of HSL. In total, 87 patients with recurrent HSL were recruited and randomly divided into two groups. Subjects received a 3-min treatment with either 1072 nm infrared light therapy or placebo (sham) light therapy three times/day for 2 days. The devices used for both groups were identical in appearance and could not be differentiated by volunteers or researchers, and 1072 nm light is invisible to the human eye. The primary endpoint was healing time, which was taken as the time for the HSL lesions to resolve fully and for the underlying skin to become completely re-epithelialized, and the secondary endpoint was lesion crusting. The median time to healing for the active group was 129 h, compared with 177 h for the control group, which was significant (P = 0.01). There was no difference between the two groups for median time to lesion crusting (P = 0.66). Compared with placebo treatment, the treatment of HSL lesions with 1072 nm infrared light significantly reduced healing time. Recent research has shown that low-level light therapy (LLLT) using 1072 nm infrared light is effective in reducing the duration of herpes simplex labialis (HSL) episodes and enhancing the healing process.BACKGROUNDRecent research has shown that low-level light therapy (LLLT) using 1072 nm infrared light is effective in reducing the duration of herpes simplex labialis (HSL) episodes and enhancing the healing process.This was a prospective, randomized, placebo-controlled, clinical trial to evaluate the efficacy of a 1072 nm light-emitting diode device for the treatment of HSL. In total, 87 patients with recurrent HSL were recruited and randomly divided into two groups. Subjects received a 3-min treatment with either 1072 nm infrared light therapy or placebo (sham) light therapy three times/day for 2 days. The devices used for both groups were identical in appearance and could not be differentiated by volunteers or researchers, and 1072 nm light is invisible to the human eye. The primary endpoint was healing time, which was taken as the time for the HSL lesions to resolve fully and for the underlying skin to become completely re-epithelialized, and the secondary endpoint was lesion crusting.METHODSThis was a prospective, randomized, placebo-controlled, clinical trial to evaluate the efficacy of a 1072 nm light-emitting diode device for the treatment of HSL. In total, 87 patients with recurrent HSL were recruited and randomly divided into two groups. Subjects received a 3-min treatment with either 1072 nm infrared light therapy or placebo (sham) light therapy three times/day for 2 days. The devices used for both groups were identical in appearance and could not be differentiated by volunteers or researchers, and 1072 nm light is invisible to the human eye. The primary endpoint was healing time, which was taken as the time for the HSL lesions to resolve fully and for the underlying skin to become completely re-epithelialized, and the secondary endpoint was lesion crusting.The median time to healing for the active group was 129 h, compared with 177 h for the control group, which was significant (P = 0.01). There was no difference between the two groups for median time to lesion crusting (P = 0.66).RESULTSThe median time to healing for the active group was 129 h, compared with 177 h for the control group, which was significant (P = 0.01). There was no difference between the two groups for median time to lesion crusting (P = 0.66).Compared with placebo treatment, the treatment of HSL lesions with 1072 nm infrared light significantly reduced healing time.CONCLUSIONSCompared with placebo treatment, the treatment of HSL lesions with 1072 nm infrared light significantly reduced healing time. Recent research has shown that low-level light therapy (LLLT) using 1072 nm infrared light is effective in reducing the duration of herpes simplex labialis (HSL) episodes and enhancing the healing process. This was a prospective, randomized, placebo-controlled, clinical trial to evaluate the efficacy of a 1072 nm light-emitting diode device for the treatment of HSL. In total, 87 patients with recurrent HSL were recruited and randomly divided into two groups. Subjects received a 3-min treatment with either 1072 nm infrared light therapy or placebo (sham) light therapy three times/day for 2 days. The devices used for both groups were identical in appearance and could not be differentiated by volunteers or researchers, and 1072 nm light is invisible to the human eye. The primary endpoint was healing time, which was taken as the time for the HSL lesions to resolve fully and for the underlying skin to become completely re-epithelialized, and the secondary endpoint was lesion crusting. The median time to healing for the active group was 129 h, compared with 177 h for the control group, which was significant (P = 0.01). There was no difference between the two groups for median time to lesion crusting (P = 0.66). Compared with placebo treatment, the treatment of HSL lesions with 1072 nm infrared light significantly reduced healing time.
Author	Dougal, G. Lee, S. Y.
Author_xml	– sequence: 1 givenname: G. surname: Dougal fullname: Dougal, G. email: : Dr Gordon Dougal, Virulite Distribution Ltd, Evans Incubation Centre, Newton Aycliffe, Durham, DL56XP, UK, viruliteg@gmail.com organization: Virulite Distribution Ltd, Evans Incubation Centre, Newton AycliffeDurham, UK – sequence: 2 givenname: S. Y. surname: Lee fullname: Lee, S. Y. organization: Hayan-nara Dermatology Group, Seoul, South Korea
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Evidence of selective cytoprotection by IR1072 publication-title: J Photochem Photobiol, B doi: 10.1016/j.jphotobiol.2005.05.005 – volume: 37 start-page: 107 year: 2008 ident: 10.1111/ced.12069-BIB0001\|ced12069-cit-0001 article-title: Herpes simplex virus type 1 infection: overview on relevant clinico-pathological features publication-title: J Oral Pathol Med doi: 10.1111/j.1600-0714.2007.00586.x – volume: 42 start-page: 82 year: 2009 ident: 10.1111/ced.12069-BIB0016\|ced12069-cit-0016 article-title: Impact of low-intensity laser on the suppression of infections caused by herpes simplex viruses 1 and 2: in vitro study publication-title: Rev Soc Bras Med Trop doi: 10.1590/S0037-86822009000100018 – volume: 999 start-page: 2625 year: 1997 ident: 10.1111/ced.12069-BIB0032\|ced12069-cit-0032 article-title: Nitric oxide synthase lies downstream from vascular endothelial growth factor-induced but not fibroblast growth factor induced angiogenesis publication-title: J Clin Invest doi: 10.1172/JCI119451 – volume: 61 start-page: 1708 year: 2000 ident: 10.1111/ced.12069-BIB0005\|ced12069-cit-0005 article-title: Treatment of common cutaneous herpes simplex virus infections publication-title: Am Fam Physician – volume: 18 start-page: 4 year: 1997 ident: 10.1111/ced.12069-BIB0031\|ced12069-cit-0031 article-title: The biology of vascular endothelial growth factor publication-title: Endocr Rev doi: 10.1210/er.18.1.4 – volume: 58 start-page: 667 year: 1984 ident: 10.1111/ced.12069-BIB0021\|ced12069-cit-0021 article-title: Pathogenesis of recurrent herpes simplex labialis IV. Maturation of lesions within 8 hours after onset and implications for antiviral treatment publication-title: Oral Surg Oral Med Oral Pathol doi: 10.1016/0030-4220(84)90031-8 – volume: 45 start-page: 804 year: 2005 ident: 10.1111/ced.12069-BIB0006\|ced12069-cit-0006 article-title: Antiviral drug-induced nephrotoxicity publication-title: Am J Kidney Dis doi: 10.1053/j.ajkd.2005.02.010 – volume: 109 start-page: 321 year: 1983 ident: 10.1111/ced.12069-BIB0020\|ced12069-cit-0020 article-title: Topical acyclovir in the management of recurrent herpes labialis publication-title: Br J Dermatol doi: 10.1111/j.1365-2133.1983.tb03548.x – volume: 31 start-page: 638 year: 2006 ident: 10.1111/ced.12069-BIB0009\|ced12069-cit-0009 article-title: A randomised double-blind study comparing the effect of 1072-nm light against placebo for the treatment of herpes labialis publication-title: Clin Exp Dermatol doi: 10.1111/j.1365-2230.2006.02191.x – volume: 293 start-page: 945 year: 1975 ident: 10.1111/ced.12069-BIB0013\|ced12069-cit-0013 article-title: Failure of neutral-red photodynamic inactivation in recurrent herpes simplex virus infections publication-title: N Engl J Med doi: 10.1056/NEJM197511062931901 – volume: 26 start-page: 149 year: 2001 ident: 10.1111/ced.12069-BIB0008\|ced12069-cit-0008 article-title: A pilot study of treatment of herpes labialis with 1072 nm narrow waveband light publication-title: Clin Exp Dermatol doi: 10.1046/j.1365-2230.2001.00783.x – volume: 27 start-page: 357 year: 2009 ident: 10.1111/ced.12069-BIB0014\|ced12069-cit-0014 article-title: Photodynamic therapy can be effective as a treatment for herpes simplex labialis publication-title: Photomed Laser Surg doi: 10.1089/pho.2008.2268 – volume: 9 start-page: 283 year: 2004 ident: 10.1111/ced.12069-BIB0029\|ced12069-cit-0029 article-title: Wound healing: an overview of acute, fibrotic and delayed healing publication-title: Front Biosci doi: 10.2741/1184
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Snippet	Summary Background Recent research has shown that low‐level light therapy (LLLT) using 1072 nm infrared light is effective in reducing the duration of herpes... Recent research has shown that low-level light therapy (LLLT) using 1072 nm infrared light is effective in reducing the duration of herpes simplex labialis... Summary Background Recent research has shown that low-level light therapy (LLLT) using 1072 nm infrared light is effective in reducing the duration of herpes...
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SubjectTerms	Adult Aged Clinical trials Female Herpes Labialis - pathology Herpes Labialis - therapy Humans Infrared Rays - therapeutic use Male Middle Aged Phototherapy - instrumentation Phototherapy - methods Prospective Studies Wound Healing - radiation effects Young Adult
Title	Evaluation of the efficacy of low-level light therapy using 1072 nm infrared light for the treatment of herpes simplex labialis
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