Metabolic syndrome is associated with increased seminal inflammatory cytokines and reproductive dysfunction in a case-controlled male cohort

Problem The impact of metabolic syndrome (MetS) associated systemic inflammation on the male reproductive tract requires further investigation. Method of study A cross‐sectional case‐controlled study design consisting of a control group (n=32) and a MetS (n=42) group was used. Variables include MetS...

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Published inAmerican journal of reproductive immunology (1989) Vol. 76; no. 2; pp. 155 - 163
Main Authors Leisegang, Kristian, Bouic, Patrick J. D., Henkel, Ralf R.
Format Journal Article
LanguageEnglish
Published Denmark Blackwell Publishing Ltd 01.08.2016
Wiley Subscription Services, Inc
Subjects
Adult
Aged
C-Reactive Protein - immunology
Case-Control Studies
cytokines
Cytokines - immunology
DNA Fragmentation
Fertility - immunology
Humans
inflammation
Male
male fertility
Membrane Potential, Mitochondrial - immunology
Metabolic syndrome
Metabolic Syndrome - immunology
Middle Aged
Semen - immunology
semen parameters
Sperm
Sperm Count
Spermatozoa - immunology
metabolic syndrome
cytokines
male fertility
inflammation
semen parameters
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Abstract Problem The impact of metabolic syndrome (MetS) associated systemic inflammation on the male reproductive tract requires further investigation. Method of study A cross‐sectional case‐controlled study design consisting of a control group (n=32) and a MetS (n=42) group was used. Variables include MetS diagnostic criterion, serum C‐Reactive Protein (CRP), routine semen analysis, spermatozoa mitochondrial membrane potential (MMP) and DNA fragmentation (DF), as well as TNF‐α, IL‐1β, IL6 and IL8 concentrations in serum and semen. Results Serum and seminal levels of TNF‐α, IL‐1β, IL6 and IL8 were all significantly increased in the MetS group. Ejaculation volume, sperm concentration, total sperm count, progressive and total motility and vitality were significantly decreased and sperm with abnormal MMP and DF were increased in the MetS group. Conclusion The results suggest that MetS is associated with decreased fertility parameters in males, as well as local reproductive tract inflammation, in the absence of leukocytospermia.
AbstractList The impact of metabolic syndrome (MetS) associated systemic inflammation on the male reproductive tract requires further investigation. A cross-sectional case-controlled study design consisting of a control group (n=32) and a MetS (n=42) group was used. Variables include MetS diagnostic criterion, serum C-Reactive Protein (CRP), routine semen analysis, spermatozoa mitochondrial membrane potential (MMP) and DNA fragmentation (DF), as well as TNF-α, IL-1β, IL6 and IL8 concentrations in serum and semen. Serum and seminal levels of TNF-α, IL-1β, IL6 and IL8 were all significantly increased in the MetS group. Ejaculation volume, sperm concentration, total sperm count, progressive and total motility and vitality were significantly decreased and sperm with abnormal MMP and DF were increased in the MetS group. The results suggest that MetS is associated with decreased fertility parameters in males, as well as local reproductive tract inflammation, in the absence of leukocytospermia.
PROBLEMThe impact of metabolic syndrome (MetS) associated systemic inflammation on the male reproductive tract requires further investigation.METHOD OF STUDYA cross-sectional case-controlled study design consisting of a control group (n=32) and a MetS (n=42) group was used. Variables include MetS diagnostic criterion, serum C-Reactive Protein (CRP), routine semen analysis, spermatozoa mitochondrial membrane potential (MMP) and DNA fragmentation (DF), as well as TNF-α, IL-1β, IL6 and IL8 concentrations in serum and semen.RESULTSSerum and seminal levels of TNF-α, IL-1β, IL6 and IL8 were all significantly increased in the MetS group. Ejaculation volume, sperm concentration, total sperm count, progressive and total motility and vitality were significantly decreased and sperm with abnormal MMP and DF were increased in the MetS group.CONCLUSIONThe results suggest that MetS is associated with decreased fertility parameters in males, as well as local reproductive tract inflammation, in the absence of leukocytospermia.
Problem The impact of metabolic syndrome (MetS) associated systemic inflammation on the male reproductive tract requires further investigation. Method of study A cross‐sectional case‐controlled study design consisting of a control group (n=32) and a MetS (n=42) group was used. Variables include MetS diagnostic criterion, serum C‐Reactive Protein (CRP), routine semen analysis, spermatozoa mitochondrial membrane potential (MMP) and DNA fragmentation (DF), as well as TNF‐α, IL‐1β, IL6 and IL8 concentrations in serum and semen. Results Serum and seminal levels of TNF‐α, IL‐1β, IL6 and IL8 were all significantly increased in the MetS group. Ejaculation volume, sperm concentration, total sperm count, progressive and total motility and vitality were significantly decreased and sperm with abnormal MMP and DF were increased in the MetS group. Conclusion The results suggest that MetS is associated with decreased fertility parameters in males, as well as local reproductive tract inflammation, in the absence of leukocytospermia.
Problem The impact of metabolic syndrome (MetS) associated systemic inflammation on the male reproductive tract requires further investigation. Method of study A cross-sectional case-controlled study design consisting of a control group (n=32) and a MetS (n=42) group was used. Variables include MetS diagnostic criterion, serum C-Reactive Protein (CRP), routine semen analysis, spermatozoa mitochondrial membrane potential (MMP) and DNA fragmentation (DF), as well as TNF- alpha , IL-1 beta , IL6 and IL8 concentrations in serum and semen. Results Serum and seminal levels of TNF- alpha , IL-1 beta , IL6 and IL8 were all significantly increased in the MetS group. Ejaculation volume, sperm concentration, total sperm count, progressive and total motility and vitality were significantly decreased and sperm with abnormal MMP and DF were increased in the MetS group. Conclusion The results suggest that MetS is associated with decreased fertility parameters in males, as well as local reproductive tract inflammation, in the absence of leukocytospermia.
Problem The impact of metabolic syndrome (MetS) associated systemic inflammation on the male reproductive tract requires further investigation. Method of study A cross‐sectional case‐controlled study design consisting of a control group (n=32) and a MetS (n=42) group was used. Variables include MetS diagnostic criterion, serum C‐Reactive Protein ( CRP ), routine semen analysis, spermatozoa mitochondrial membrane potential ( MMP ) and DNA fragmentation ( DF ), as well as TNF ‐α, IL ‐1β, IL 6 and IL 8 concentrations in serum and semen. Results Serum and seminal levels of TNF ‐α, IL ‐1β, IL 6 and IL 8 were all significantly increased in the MetS group. Ejaculation volume, sperm concentration, total sperm count, progressive and total motility and vitality were significantly decreased and sperm with abnormal MMP and DF were increased in the MetS group. Conclusion The results suggest that MetS is associated with decreased fertility parameters in males, as well as local reproductive tract inflammation, in the absence of leukocytospermia.
Author Leisegang, Kristian
Henkel, Ralf R.
Bouic, Patrick J. D.
Author_xml – sequence: 1
  givenname: Kristian
  surname: Leisegang
  fullname: Leisegang, Kristian
  email: kleisegang@uwc.ac.za
  organization: School of Natural Medicine, University of the Western Cape, Bellville, South Africa
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  givenname: Patrick J. D.
  surname: Bouic
  fullname: Bouic, Patrick J. D.
  organization: Division of Medical Microbiology, Department of Pathology, Stellenbosch University & Synexa Life Sciences, Cape Town, South Africa
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  givenname: Ralf R.
  surname: Henkel
  fullname: Henkel, Ralf R.
  organization: Department of Medical Biosciences, University of the Western Cape, Bellville, South Africa
BackLink https://www.ncbi.nlm.nih.gov/pubmed/27334450$$D View this record in MEDLINE/PubMed
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Keywords metabolic syndrome
cytokines
male fertility
inflammation
semen parameters
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Snippet Problem The impact of metabolic syndrome (MetS) associated systemic inflammation on the male reproductive tract requires further investigation. Method of study...
The impact of metabolic syndrome (MetS) associated systemic inflammation on the male reproductive tract requires further investigation. A cross-sectional...
Problem The impact of metabolic syndrome (MetS) associated systemic inflammation on the male reproductive tract requires further investigation. Method of study...
PROBLEMThe impact of metabolic syndrome (MetS) associated systemic inflammation on the male reproductive tract requires further investigation.METHOD OF STUDYA...
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pubmed
wiley
istex
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StartPage 155
SubjectTerms Adult
Aged
C-Reactive Protein - immunology
Case-Control Studies
cytokines
Cytokines - immunology
DNA Fragmentation
Fertility - immunology
Humans
inflammation
Male
male fertility
Membrane Potential, Mitochondrial - immunology
Metabolic syndrome
Metabolic Syndrome - immunology
Middle Aged
Semen - immunology
semen parameters
Sperm
Sperm Count
Spermatozoa - immunology
Title Metabolic syndrome is associated with increased seminal inflammatory cytokines and reproductive dysfunction in a case-controlled male cohort
URI https://api.istex.fr/ark:/67375/WNG-M178KDKV-N/fulltext.pdf
https://onlinelibrary.wiley.com/doi/abs/10.1111%2Faji.12529
https://www.ncbi.nlm.nih.gov/pubmed/27334450
https://www.proquest.com/docview/1803048958
https://search.proquest.com/docview/1803798130
https://search.proquest.com/docview/1808629716
Volume 76
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