Antibody Production and Th1-biased Response Induced by an Epitope Vaccine Composed of Cholera Toxin B Unit and Helicobacter pylori Lpp20 Epitopes

• Published in: Helicobacter (Cambridge, Mass.) Vol. 21; no. 3; pp. 234 - 248
• Main Authors: Li, Yan, Chen, Zhongbiao, Ye, Jianbin, Ning, Lijun, Luo, Jun, Zhang, Lili, Jiang, Yin, Xi, Yue, Ning, Yunshan
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.06.2016; Wiley Subscription Services, Inc
• Subjects: Adjuvants, Immunologic; Animals; antibody; Antigens, Bacterial - immunology; Bacterial Vaccines - immunology; Cholera Toxin - immunology; cytokine; Cytokines - metabolism; epitope vaccine; Epitopes - immunology; Escherichia coli; Helicobacter Infections - microbiology; Helicobacter Infections - prevention & control; Helicobacter pylori; Helicobacter pylori - immunology; Humans; Immunization; Injections, Intraperitoneal; Lpp20 epitope; Male; Mice; Mice, Inbred BALB C; Specific Pathogen-Free Organisms; cytokine; Lpp20 epitope; antibody; Helicobacter pylori; epitope vaccine

Background The epitope vaccine is an attractive potential for prophylactic and therapeutic vaccination against Helicobacter pylori (H. pylori) infection. Lpp20 is one of major protective antigens which trigger immune response after H. pylori invades host and has been considered as an excellent vacci...