Discrimination of non-melanoma skin lesions from non-tumor human skin tissues in vivo using Raman spectroscopy and multivariate statistics

• Published in: Lasers in surgery and medicine Vol. 47; no. 1; pp. 6 - 16
• Main Authors: Silveira, Fabricio L., Pacheco, Marcos T.T., Bodanese, Benito, Pasqualucci, Carlos A., Zângaro, Renato A., Silveira Jr, Landulfo
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.01.2015; Wiley Subscription Services, Inc
• Subjects: Adult; Aged; Algorithms; Carcinoma, Basal Cell - diagnosis; Carcinoma, Squamous Cell - diagnosis; Case-Control Studies; Decision Support Techniques; Diagnosis, Differential; Discriminant Analysis; Female; Humans; in vivo diagnosis; Keratosis, Actinic - diagnosis; Least-Squares Analysis; Male; Middle Aged; Multivariate Analysis; near-infrared Raman spectroscopy; partial least squares; Principal Component Analysis; principal components analysis; Skin Neoplasms - diagnosis; skin tissues; Spectroscopy, Near-Infrared; Spectrum Analysis, Raman - methods; skin tissues; in vivo diagnosis; discriminant analysis; partial least squares; near-infrared Raman spectroscopy; principal components analysis

Background and Objective Raman spectroscopy was used to discriminate human non‐melanoma skin lesions from non‐tumor tissues in vivo. This work proposed the discrimination between non‐melanoma (basal cell carcinoma, BCC; squamous cell carcinoma, SCC) and pre‐cancerous lesions (actinic keratosis, AK)...