Intracranial hyperthermia through local photothermal heating with a fiberoptic microneedle device

• Published in: Lasers in surgery and medicine Vol. 45; no. 3; pp. 167 - 174
• Main Authors: Hood, R. Lyle, Rossmeisl Jr, John H., Andriani Jr, Rudy T., Wilkinson, Ashley R., Robertson, John L., Rylander, Christopher G.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.03.2013; Wiley Subscription Services, Inc
• Subjects: Albumin; Animals; Body Temperature; Cerebrum - drug effects; Cerebrum - pathology; Cerebrum - radiation effects; convection-enhanced delivery; Evans Blue - administration & dosage; Evans Blue - pharmacology; Hyperthermia, Induced - instrumentation; Hyperthermia, Induced - methods; laser-induced thermotherapy; Lasers; Male; malignant glioma; microneedle; Necrosis; Needles; Optical Fibers; photothermal; Rats; Rats, Inbred F344; Serum Albumin - administration & dosage; Serum Albumin - pharmacology; sub-lethal hyperthermia

Background and Objectives The fiberoptic microneedle device (FMD) seeks to leverage advantages of both laser‐induced thermal therapy (LITT) and convection‐enhanced delivery (CED) to increase volumetric dispersal of locally infused chemotherapeutics through sub‐lethal photothermal heat generation. Th...