Astrocyte modulation of in vitro β-amyloid neurotoxicity

• Published in: Glia Vol. 46; no. 3; pp. 252 - 260
• Main Authors: Paradisi, Silvia, Sacchetti, Benedetto, Balduzzi, Maria, Gaudi, Simona, Malchiodi-Albedi, Fiorella
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.05.2004; Wiley-Liss
• Subjects: Alzheimer's disease; Amyloid beta-Peptides - toxicity; Animals; apoptosis; astrocytes; Astrocytes - cytology; Astrocytes - drug effects; Astrocytes - physiology; Biological and medical sciences; Cells, Cultured; cocultures; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Fundamental and applied biological sciences. Psychology; hippocampal neurons; Hippocampus - cytology; Hippocampus - drug effects; Hippocampus - physiology; Isolated neuron and nerve. Neuroglia; Medical sciences; neuritic dysplasia; Neurology; neurotoxicity; Rats; Rats, Wistar; synaptic loss; Vertebrates: nervous system and sense organs; β-amyloid; Nervous system diseases; Glial cell; Dysplasia; Alzheimer disease; Neuroglia; Central nervous system; neuritic dysplasia; Astrocyte; In vitro; hippocampal neurons; Cerebral disorder; Neurotoxicity; Neuron; cocultures; synaptic loss; Cell death; β Amyloid protein; Central nervous system disease; Degenerative disease; astrocytes; Alzheimer's disease; Hippocampus; Apoptosis; β-amyloid

In Alzheimer's disease brain, β‐amyloid (Aβ) deposition is accompanied by astrocyte activation, whose role in the pathogenesis of the disease is still unclear. To explore the subject, we compared Aβ neurotoxicity in pure hippocampal cultures and neuronal‐astrocytic cocultures, where astrocytes...