Serum concentration and dose-response relationships for carprofen in rheumatoid arthritis

• Published in: Clinical pharmacology and therapeutics Vol. 44; no. 2; p. 186
• Main Authors: Furst, D E, Caldwell, J R, Klugman, M P, Enthoven, D, Rittweger, K, Scheer, R, Sarkissian, E, Dromgoole, S
• Format: Journal Article
• Language: English
• Published: United States 01.08.1988
• Subjects: Adult; Aged; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal - administration & dosage; Arthritis, Rheumatoid - drug therapy; Carbazoles - administration & dosage; Carbazoles - blood; Clinical Trials as Topic; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Middle Aged; Random Allocation; Regression Analysis

Thirty-eight patients with active, definite, or classical rheumatoid arthritis were tested in a double-blind, 3-week-per-arm, multiple-crossover, randomized, block-design comparison of 100, 300, 600, and 800 mg/day carprofen given b.i.d. A linear dose-response relationship was demonstrated for six o...