Cerebrovascular reactivity measurements using simultaneous 15O-water PET and ASL MRI: Impacts of arterial transit time, labeling efficiency, and hematocrit

• Published in: NeuroImage (Orlando, Fla.) Vol. 233; p. 117955
• Main Authors: Zhao, Moss Y, Fan, Audrey P, Chen, David Yen-Ting, Sokolska, Magdalena J., Guo, Jia, Ishii, Yosuke, Shin, David D, Khalighi, Mohammad Mehdi, Holley, Dawn, Halbert, Kim, Otte, Andrea, Williams, Brittney, Rostami, Taghi, Park, Jun-Hyung, Shen, Bin, Zaharchuk, Greg
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.06.2021; Elsevier
• Subjects: Cerebral blood flow; Cerebrovascular reactivity; Cerebrovascular reserve; Magnetic resonance imaging; PET/MRI; Positron emission tomography; Pseudo-continuous arterial spin labeling; Velocity selective arterial spin labeling; NEX; ATT; PCASL; CBF; PLD; Vc; Cerebrovascular reactivity; Cerebrovascular reserve; PET/MRI; Cerebral blood flow; WM; ASL; AIF; VSASL; BRAVO; GM; OSEM; TOF; RMSE; FOV; ROI; PC; Magnetic resonance imaging; TCD; FWHM; ACZ; Pseudo-continuous arterial spin labeling; GRE; Positron emission tomography; MRA; CVR; TR; Velocity selective arterial spin labeling

Cerebrovascular reactivity (CVR) reflects the capacity of the brain to meet changing physiological demands and can predict the risk of cerebrovascular diseases. CVR can be obtained by measuring the change in cerebral blood flow (CBF) during a brain stress test where CBF is altered by a vasodilator s...