The link between CD8+ T-cell antigen-sensitivity and HIV-suppressive capacity depends on HLA restriction, target epitope and viral isolate

• Published in: AIDS (London) Vol. 28; no. 4; pp. 477 - 486
• Main Authors: Lissina, Anna, Fastenackels, Solène, Inglesias, Maria C., Ladell, Kristin, McLaren, James E., Briceño, Olivia, Gostick, Emma, Papagno, Laura, Autran, Brigitte, Sauce, Delphine, Price, David A., Saez-Cirion, Asier, Appay, Victor
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins, Inc 20.02.2014; Lippincott Williams & Wilkins; Wolters Kluwer
• Subjects: Biological and medical sciences; CD8-Positive T-Lymphocytes - immunology; Epitopes - immunology; gag Gene Products, Human Immunodeficiency Virus - immunology; HIV Antigens - immunology; HIV Infections - immunology; HIV Infections - virology; HLA Antigens - immunology; Human viral diseases; Humans; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunology; Immunopathology; Infectious diseases; Life Sciences; Medical sciences; nef Gene Products, Human Immunodeficiency Virus - immunology; Receptors, Antigen, T-Cell - immunology; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Immunopathology; HLA-System; TCR avidity; T cell receptor; Antigenic determinant; Retroviridae; AIDS; Immune deficiency; Lentivirus; Infection; Virus; Sensitivity; Immunological investigation; Viral disease; CD8; T-Lymphocyte; viral suppression; Human immunodeficiency virus; T lymphocyte; HIV epitope; T antigen; antigen-sensitivity; CD8-Positive T-Lymphocytes; HIV Infections; Antigen; gag Gene Products; nef Gene Products; Receptors; Human Immunodeficiency Virus; Humans; T-Cell; Epitopes; HLA Antigens; HIV Antigens

BACKGROUND:Although it is established that CD8 T-cell immunity is critical for the control of HIV replication in vivo, the key factors that determine antiviral efficacy are yet to be fully elucidated. Antigen-sensitivity and T-cell receptor (TCR) avidity have been identified as potential determinant...