Primary islet autoantibody at initial seroconversion and autoantibodies at diagnosis of type 1 diabetes as markers of disease heterogeneity

• Published in: Pediatric diabetes Vol. 19; no. 2; pp. 284 - 292
• Main Authors: Ilonen, Jorma, Lempainen, Johanna, Hammais, Anna, Laine, Antti‐Pekka, Härkönen, Taina, Toppari, Jorma, Veijola, Riitta, Knip, Mikael
• Format: Journal Article
• Language: English
• Published: Former Munksgaard John Wiley & Sons A/S 01.03.2018; Wiley Subscription Services, Inc
• Subjects: Autoantibodies; Autoimmunity; Children; Diabetes; Diabetes mellitus; Diabetes mellitus (insulin dependent); Diagnosis; disease heterogeneity; ErbB-3 protein; genetics; Genotypes; Genotyping; Glutamate decarboxylase; Glutamic acid; Immunoglobulins; Insulin; islet autoantibodies; Medical diagnosis; Seroconversion; type 1 diabetes; Zinc transporter; type 1 diabetes; genetics; islet autoantibodies; disease heterogeneity

Objective The relationship between patterns of islet autoantibodies at diagnosis and specificity of the first islet autoantibody at the initiation of autoimmunity was analyzed with the aim of identifying patterns informative of the primary autoantibodies. Methods Information about a single first aut...