Lower serum osteocalcin concentrations are associated with brain microstructural changes and worse cognitive performance

• Published in: Clinical endocrinology (Oxford) Vol. 84; no. 5; pp. 756 - 763
• Main Authors: Puig, Josep, Blasco, Gerard, Daunis-i-Estadella, Josep, Moreno, María, Molina, Xavier, Alberich-Bayarri, Angel, Xifra, Gemma, Pedraza, Salvador, Ricart, Wifredo, Fernández-Aranda, Fernando, Fernández-Real, José Manuel
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.05.2016; Wiley Subscription Services, Inc
• Subjects: Adult; Anisotropy; Bayes Theorem; Body Mass Index; Brain - pathology; Brain - physiopathology; Cognition - physiology; Cross-Sectional Studies; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Multivariate Analysis; Neuropsychological Tests; NMR; Nuclear magnetic resonance; Obesity - blood; Obesity - physiopathology; Obesity - psychology; Osteocalcin - blood; Predictive Value of Tests

Summary Objective Rodent models have found that osteocalcin crosses the blood–brain barrier and regulates behaviour. No data are available on osteocalcin's effects on brain microstructure and cognitive performance in humans. We evaluated the association between serum osteocalcin concentrations...