Lower serum osteocalcin concentrations are associated with brain microstructural changes and worse cognitive performance
Summary Objective Rodent models have found that osteocalcin crosses the blood–brain barrier and regulates behaviour. No data are available on osteocalcin's effects on brain microstructure and cognitive performance in humans. We evaluated the association between serum osteocalcin concentrations...
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| Published in | Clinical endocrinology (Oxford) Vol. 84; no. 5; pp. 756 - 763 |
|---|---|
| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Blackwell Publishing Ltd
01.05.2016
Wiley Subscription Services, Inc |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Summary
Objective
Rodent models have found that osteocalcin crosses the blood–brain barrier and regulates behaviour. No data are available on osteocalcin's effects on brain microstructure and cognitive performance in humans. We evaluated the association between serum osteocalcin concentrations and (i) brain microstructural changes on magnetic resonance imaging (MRI) and (ii) neuropsychological performance.
Design, Patients and Measurements
We studied 24 consecutive obese subjects (13 women; age, 49·8 ± 8·1 years; body mass index [BMI], 43·9 ± 4·54 kg/m2) and 20 healthy volunteers (10 women; age, 48·8 ± 9·5 years; BMI, 24·3 ± 3·54 kg/m2) in a cross‐sectional study within the multicentre FLORINASH Project. FLAIR signal intensity and DTI‐metrics (primary (λ1), secondary (λ2) and tertiary (λ3) eigenvalues; fractional anisotropy (FA); and mean diffusivity) in the caudate, hypothalamus, thalamus and putamen, and in subcortical white matter were assessed. Cognitive performance evaluated by neuropsychological test battery.
Results
Lower osteocalcin concentrations were associated with BMI, higher λ1, λ2 and λ3 values at the caudate and lower FLAIR signal intensity at the caudate and putamen. Obese patients with lower osteocalcin concentrations had higher FA at putamen and thalamus. Lower osteocalcin concentrations were associated with higher Iowa Gambling Task (IGT) scores. FLAIR signal intensity at the caudate <601·832 yielded 85·7% sensitivity, 64·3% specificity, 70·6% negative predictive value and 81·8% positive predictive value for IGT score. Lower osteocalcin was an independent predictor of worse cognitive performance on multivariate analysis (F = 3·551, P = 0·01343; R2 = 0·103). Bayesian information criterion demonstrated that osteocalcin had the predominant role in predicting IGT score.
Conclusions
Lower serum osteocalcin concentrations are associated with brain microstructural changes and worse cognitive performance. |
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| AbstractList | Rodent models have found that osteocalcin crosses the blood-brain barrier and regulates behaviour. No data are available on osteocalcin's effects on brain microstructure and cognitive performance in humans. We evaluated the association between serum osteocalcin concentrations and (i) brain microstructural changes on magnetic resonance imaging (MRI) and (ii) neuropsychological performance.
We studied 24 consecutive obese subjects (13 women; age, 49·8 ± 8·1 years; body mass index [BMI], 43·9 ± 4·54 kg/m(2) ) and 20 healthy volunteers (10 women; age, 48·8 ± 9·5 years; BMI, 24·3 ± 3·54 kg/m(2) ) in a cross-sectional study within the multicentre FLORINASH Project. FLAIR signal intensity and DTI-metrics (primary (λ1 ), secondary (λ2 ) and tertiary (λ3 ) eigenvalues; fractional anisotropy (FA); and mean diffusivity) in the caudate, hypothalamus, thalamus and putamen, and in subcortical white matter were assessed. Cognitive performance evaluated by neuropsychological test battery.
Lower osteocalcin concentrations were associated with BMI, higher λ1, λ2 and λ3 values at the caudate and lower FLAIR signal intensity at the caudate and putamen. Obese patients with lower osteocalcin concentrations had higher FA at putamen and thalamus. Lower osteocalcin concentrations were associated with higher Iowa Gambling Task (IGT) scores. FLAIR signal intensity at the caudate <601·832 yielded 85·7% sensitivity, 64·3% specificity, 70·6% negative predictive value and 81·8% positive predictive value for IGT score. Lower osteocalcin was an independent predictor of worse cognitive performance on multivariate analysis (F = 3·551, P = 0·01343; R(2) = 0·103). Bayesian information criterion demonstrated that osteocalcin had the predominant role in predicting IGT score.
Lower serum osteocalcin concentrations are associated with brain microstructural changes and worse cognitive performance. Objective Rodent models have found that osteocalcin crosses the blood-brain barrier and regulates behaviour. No data are available on osteocalcin's effects on brain microstructure and cognitive performance in humans. We evaluated the association between serum osteocalcin concentrations and (i) brain microstructural changes on magnetic resonance imaging (MRI) and (ii) neuropsychological performance. Design, Patients and Measurements We studied 24 consecutive obese subjects (13 women; age, 49.8 plus or minus 8.1 years; body mass index [BMI], 43.9 plus or minus 4.54 kg/m super(2)) and 20 healthy volunteers (10 women; age, 48.8 plus or minus 9.5 years; BMI, 24.3 plus or minus 3.54 kg/m super(2)) in a cross-sectional study within the multicentre FLORINASH Project. FLAIR signal intensity and DTI-metrics (primary ( lambda sub(1)), secondary ( lambda sub(2)) and tertiary ( lambda sub(3)) eigenvalues; fractional anisotropy (FA); and mean diffusivity) in the caudate, hypothalamus, thalamus and putamen, and in subcortical white matter were assessed. Cognitive performance evaluated by neuropsychological test battery. Results Lower osteocalcin concentrations were associated with BMI, higher lambda sub(1,) lambda sub(2) and lambda sub(3) values at the caudate and lower FLAIR signal intensity at the caudate and putamen. Obese patients with lower osteocalcin concentrations had higher FA at putamen and thalamus. Lower osteocalcin concentrations were associated with higher Iowa Gambling Task (IGT) scores. FLAIR signal intensity at the caudate <601.832 yielded 85.7% sensitivity, 64.3% specificity, 70.6% negative predictive value and 81.8% positive predictive value for IGT score. Lower osteocalcin was an independent predictor of worse cognitive performance on multivariate analysis (F = 3.551, P = 0.01343; R super(2) = 0.103). Bayesian information criterion demonstrated that osteocalcin had the predominant role in predicting IGT score. Conclusions Lower serum osteocalcin concentrations are associated with brain microstructural changes and worse cognitive performance. OBJECTIVERodent models have found that osteocalcin crosses the blood-brain barrier and regulates behaviour. No data are available on osteocalcin's effects on brain microstructure and cognitive performance in humans. We evaluated the association between serum osteocalcin concentrations and (i) brain microstructural changes on magnetic resonance imaging (MRI) and (ii) neuropsychological performance.DESIGN, PATIENTS AND MEASUREMENTSWe studied 24 consecutive obese subjects (13 women; age, 49·8 ± 8·1 years; body mass index [BMI], 43·9 ± 4·54 kg/m(2) ) and 20 healthy volunteers (10 women; age, 48·8 ± 9·5 years; BMI, 24·3 ± 3·54 kg/m(2) ) in a cross-sectional study within the multicentre FLORINASH Project. FLAIR signal intensity and DTI-metrics (primary (λ1 ), secondary (λ2 ) and tertiary (λ3 ) eigenvalues; fractional anisotropy (FA); and mean diffusivity) in the caudate, hypothalamus, thalamus and putamen, and in subcortical white matter were assessed. Cognitive performance evaluated by neuropsychological test battery.RESULTSLower osteocalcin concentrations were associated with BMI, higher λ1, λ2 and λ3 values at the caudate and lower FLAIR signal intensity at the caudate and putamen. Obese patients with lower osteocalcin concentrations had higher FA at putamen and thalamus. Lower osteocalcin concentrations were associated with higher Iowa Gambling Task (IGT) scores. FLAIR signal intensity at the caudate <601·832 yielded 85·7% sensitivity, 64·3% specificity, 70·6% negative predictive value and 81·8% positive predictive value for IGT score. Lower osteocalcin was an independent predictor of worse cognitive performance on multivariate analysis (F = 3·551, P = 0·01343; R(2) = 0·103). Bayesian information criterion demonstrated that osteocalcin had the predominant role in predicting IGT score.CONCLUSIONSLower serum osteocalcin concentrations are associated with brain microstructural changes and worse cognitive performance. Summary Objective Rodent models have found that osteocalcin crosses the blood-brain barrier and regulates behaviour. No data are available on osteocalcin's effects on brain microstructure and cognitive performance in humans. We evaluated the association between serum osteocalcin concentrations and (i) brain microstructural changes on magnetic resonance imaging (MRI) and (ii) neuropsychological performance. Design, Patients and Measurements We studied 24 consecutive obese subjects (13 women; age, 49·8 ± 8·1 years; body mass index [BMI], 43·9 ± 4·54 kg/m2) and 20 healthy volunteers (10 women; age, 48·8 ± 9·5 years; BMI, 24·3 ± 3·54 kg/m2) in a cross-sectional study within the multicentre FLORINASH Project. FLAIR signal intensity and DTI-metrics (primary (λ1), secondary (λ2) and tertiary (λ3) eigenvalues; fractional anisotropy (FA); and mean diffusivity) in the caudate, hypothalamus, thalamus and putamen, and in subcortical white matter were assessed. Cognitive performance evaluated by neuropsychological test battery. Results Lower osteocalcin concentrations were associated with BMI, higher λ1, λ2 and λ3 values at the caudate and lower FLAIR signal intensity at the caudate and putamen. Obese patients with lower osteocalcin concentrations had higher FA at putamen and thalamus. Lower osteocalcin concentrations were associated with higher Iowa Gambling Task (IGT) scores. FLAIR signal intensity at the caudate <601·832 yielded 85·7% sensitivity, 64·3% specificity, 70·6% negative predictive value and 81·8% positive predictive value for IGT score. Lower osteocalcin was an independent predictor of worse cognitive performance on multivariate analysis (F = 3·551, P = 0·01343; R2 = 0·103). Bayesian information criterion demonstrated that osteocalcin had the predominant role in predicting IGT score. Conclusions Lower serum osteocalcin concentrations are associated with brain microstructural changes and worse cognitive performance. Summary Objective Rodent models have found that osteocalcin crosses the blood–brain barrier and regulates behaviour. No data are available on osteocalcin's effects on brain microstructure and cognitive performance in humans. We evaluated the association between serum osteocalcin concentrations and (i) brain microstructural changes on magnetic resonance imaging (MRI) and (ii) neuropsychological performance. Design, Patients and Measurements We studied 24 consecutive obese subjects (13 women; age, 49·8 ± 8·1 years; body mass index [BMI], 43·9 ± 4·54 kg/m2) and 20 healthy volunteers (10 women; age, 48·8 ± 9·5 years; BMI, 24·3 ± 3·54 kg/m2) in a cross‐sectional study within the multicentre FLORINASH Project. FLAIR signal intensity and DTI‐metrics (primary (λ1), secondary (λ2) and tertiary (λ3) eigenvalues; fractional anisotropy (FA); and mean diffusivity) in the caudate, hypothalamus, thalamus and putamen, and in subcortical white matter were assessed. Cognitive performance evaluated by neuropsychological test battery. Results Lower osteocalcin concentrations were associated with BMI, higher λ1, λ2 and λ3 values at the caudate and lower FLAIR signal intensity at the caudate and putamen. Obese patients with lower osteocalcin concentrations had higher FA at putamen and thalamus. Lower osteocalcin concentrations were associated with higher Iowa Gambling Task (IGT) scores. FLAIR signal intensity at the caudate <601·832 yielded 85·7% sensitivity, 64·3% specificity, 70·6% negative predictive value and 81·8% positive predictive value for IGT score. Lower osteocalcin was an independent predictor of worse cognitive performance on multivariate analysis (F = 3·551, P = 0·01343; R2 = 0·103). Bayesian information criterion demonstrated that osteocalcin had the predominant role in predicting IGT score. Conclusions Lower serum osteocalcin concentrations are associated with brain microstructural changes and worse cognitive performance. Summary Objective Rodent models have found that osteocalcin crosses the blood–brain barrier and regulates behaviour. No data are available on osteocalcin's effects on brain microstructure and cognitive performance in humans. We evaluated the association between serum osteocalcin concentrations and (i) brain microstructural changes on magnetic resonance imaging ( MRI ) and (ii) neuropsychological performance. Design, Patients and Measurements We studied 24 consecutive obese subjects (13 women; age, 49·8 ± 8·1 years; body mass index [ BMI ], 43·9 ± 4·54 kg/m 2 ) and 20 healthy volunteers (10 women; age, 48·8 ± 9·5 years; BMI , 24·3 ± 3·54 kg/m 2 ) in a cross‐sectional study within the multicentre FLORINASH Project. FLAIR signal intensity and DTI ‐metrics (primary (λ 1 ), secondary (λ 2 ) and tertiary (λ 3 ) eigenvalues; fractional anisotropy ( FA ); and mean diffusivity) in the caudate, hypothalamus, thalamus and putamen, and in subcortical white matter were assessed. Cognitive performance evaluated by neuropsychological test battery. Results Lower osteocalcin concentrations were associated with BMI , higher λ 1, λ 2 and λ 3 values at the caudate and lower FLAIR signal intensity at the caudate and putamen. Obese patients with lower osteocalcin concentrations had higher FA at putamen and thalamus. Lower osteocalcin concentrations were associated with higher Iowa Gambling Task ( IGT ) scores. FLAIR signal intensity at the caudate <601·832 yielded 85·7% sensitivity, 64·3% specificity, 70·6% negative predictive value and 81·8% positive predictive value for IGT score. Lower osteocalcin was an independent predictor of worse cognitive performance on multivariate analysis ( F = 3·551, P = 0·01343; R 2 = 0·103). Bayesian information criterion demonstrated that osteocalcin had the predominant role in predicting IGT score. Conclusions Lower serum osteocalcin concentrations are associated with brain microstructural changes and worse cognitive performance. |
| Author | Blasco, Gerard Pedraza, Salvador Puig, Josep Fernández-Aranda, Fernando Ricart, Wifredo Daunis-i-Estadella, Josep Xifra, Gemma Alberich-Bayarri, Angel Fernández-Real, José Manuel Moreno, María Molina, Xavier |
| Author_xml | – sequence: 1 givenname: Josep surname: Puig fullname: Puig, Josep email: jpuigalcantara@idibgi.org organization: Department of Radiology (IDI), Research Unit, Girona Biomedical Research Institute (IDIBGI), Hospital Universitari de Girona Dr Josep Trueta, Girona, Spain – sequence: 2 givenname: Gerard surname: Blasco fullname: Blasco, Gerard organization: Department of Radiology (IDI), Research Unit, Girona Biomedical Research Institute (IDIBGI), Hospital Universitari de Girona Dr Josep Trueta, Girona, Spain – sequence: 3 givenname: Josep surname: Daunis-i-Estadella fullname: Daunis-i-Estadella, Josep organization: Department of Computer Science, Applied Mathematics and Statistics, University of Girona, Girona, Spain – sequence: 4 givenname: María surname: Moreno fullname: Moreno, María organization: Department of Diabetes, Endocrinology and Nutrition, Girona Biomedical Research Institute (IDIBGI), Hospital Universitari de Girona Dr Josep Trueta, and CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Girona, Spain – sequence: 5 givenname: Xavier surname: Molina fullname: Molina, Xavier organization: Department of Radiology (IDI), Research Unit, Girona Biomedical Research Institute (IDIBGI), Hospital Universitari de Girona Dr Josep Trueta, Girona, Spain – sequence: 6 givenname: Angel surname: Alberich-Bayarri fullname: Alberich-Bayarri, Angel organization: Biomedical Imaging Research Group (GIBI230), La Fe Polytechnics and University Hospital, La Fe Health Research Institute, Valencia, Spain – sequence: 7 givenname: Gemma surname: Xifra fullname: Xifra, Gemma organization: Department of Diabetes, Endocrinology and Nutrition, Girona Biomedical Research Institute (IDIBGI), Hospital Universitari de Girona Dr Josep Trueta, and CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Girona, Spain – sequence: 8 givenname: Salvador surname: Pedraza fullname: Pedraza, Salvador organization: Department of Radiology (IDI), Research Unit, Girona Biomedical Research Institute (IDIBGI), Hospital Universitari de Girona Dr Josep Trueta, Girona, Spain – sequence: 9 givenname: Wifredo surname: Ricart fullname: Ricart, Wifredo organization: Department of Diabetes, Endocrinology and Nutrition, Girona Biomedical Research Institute (IDIBGI), Hospital Universitari de Girona Dr Josep Trueta, and CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Girona, Spain – sequence: 10 givenname: Fernando surname: Fernández-Aranda fullname: Fernández-Aranda, Fernando organization: Department of Psychiatry, Hospital Universitari de Bellvitge, and CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Barcelona, Spain – sequence: 11 givenname: José Manuel surname: Fernández-Real fullname: Fernández-Real, José Manuel organization: Department of Diabetes, Endocrinology and Nutrition, Girona Biomedical Research Institute (IDIBGI), Hospital Universitari de Girona Dr Josep Trueta, and CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Girona, Spain |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26406918$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/j.neurobiolaging.2014.03.011 10.3389/fpsyg.2013.00665 10.1016/j.neurobiolaging.2008.04.013 10.1016/j.cell.2007.05.047 10.1177/1359104506059127 10.1097/WAD.0000000000000042 10.1177/000456320003700402 10.1016/S0896-6273(03)00848-1 10.1002/nbm.782 10.3174/ajnr.A1051 10.1006/nimg.2002.1150 10.1073/pnas.72.10.3925 10.2337/dc14-0664 10.1038/nprot.2006.115 10.1111/j.1365-2265.2012.04391.x 10.1126/science.1108062 10.4158/EP12141.RA 10.1002/wics.199 10.1016/j.cell.2013.08.042 10.1146/annurev.neuro.29.051605.112903 10.1016/j.bandc.2009.03.005 10.1002/mrm.1910290406 10.1016/j.pneurobio.2008.09.004 10.1148/radiol.12120863 10.1002/humu.10043 10.1007/s00774-012-0367-z 10.1214/12-STS402 |
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| Copyright | 2015 John Wiley & Sons Ltd 2015 John Wiley & Sons Ltd. Copyright © 2016 John Wiley & Sons Ltd |
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| Notes | istex:6E917EDD29594104021117193FCE59C6E51E1452 Table S1. Univariate associations of neuropsychological battery in all individuals according the level of osteocalcin. ark:/67375/WNG-8PW9XT1Q-G ArticleID:CEN12954 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
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| References | Nyhus, E. & Barceló, F. (2009) The Wisconsin Card Sorting Test and the cognitive assessment of prefrontal executive functions: a critical update. Brain and Cognition, 71, 437-451. Blasco, G., Puig, J., Daunis-i-Estadella, J. et al. (2014) Brain iron overload, insulin resistance, and cognitive performance in obese subjects: a preliminary MRI case-control study. Diabetes Care, 37, 3076-3083. Hauschka, P.V., Lian, J.B. & Gallop, P.M. (1975) Direct identification of the calcium-binding amino acid, γ-carboxyglutamate, in mineralized tissue. Proceedings of the National Academy of Sciences of the United States of America, 72, 3925-3929. Gong, N.J., Wong, C.S., Chan, C.C. et al. (2014) Aging in deep gray matter and white matter revealed by diffusional kurtosis imaging. Neurobiology of Aging, 35, 2203-2216. Guntur, A.R. & Rosen, C.J. (2012) Bone as an endocrine organ. Endocrine Practice, 18, 758-762. King-Casas, B., Tomlin, D., Anen, C. et al. (2005) Getting to know you: reputation and trust in a two-person economic exchange. Science, 308, 78-83. Pfefferbaum, A., Adalsteinsson, E., Rohlfing, T. et al. (2010) Diffusion tensor imaging of deep gray matter brain structures: effects of age and iron concentration. Neurobiology of Aging, 31, 482-493. Beaulieu, C. (2002) The basis of anisotropic water diffusion in the nervous system - a technical review. NMR in Biomedicine, 15, 435-455. Montague, P.R., King-Casas, B. & Cohen, J.D. (2006) Imaging valuation models in human choice. Annual Review of Neuroscience, 29, 417-448. Mukherjee, P., Berman, J.I., Chung, S.W. et al. (2008) Diffusion tensor MR imaging and fiber tractography: theoretic underpinnings. American Journal of Neuroradiology, 29, 632-641. Lee, N.K., Sowa, H., Hinoi, E. et al. (2007) Endocrine regulation of energy metabolism by the skeleton. Cell, 130, 456-469. Oury, F., Khrimian, L., Denny, C.A. et al. (2013) Maternal and offspring pools of osteocalcin influence brain development and functions. Cell, 155, 228-241. Lezak, M., Howieson, D., Bigler, E. et al. (2012) Neuropsychological Assessment, 5th edn. University Press, Oxford, UK. McBrien, H., Turk, J. & Letch, N. (2006) The management of ADHD and associated problems in a young person with cleidocranial dysostosis (CCD) and mild intellectual disability. Clinical Child Psychology and Psychiatry, 11, 445-456. Bezerra Santos dos Magalhães, K., Magalhães, M.M., Diniz, E.T. et al. (2013) Metabolic syndrome and central fat distribution are related to lower serum osteocalcin concentrations. Annals of Nutrition and Metabolism, 62, 181-186. Neath, A.A. & Cavanaugh, J.E. (2012) The Bayesian information criterion: background, derivation, and applications. WIREs Computational Statistics, 4, 199-203. Oosterwerff, M.M., van Schoor, N.M., Lips, P. et al. (2013) Osteocalcin as a predictor of the metabolic syndrome in older persons: a population-based study. Clinical Endocrinology, 78, 242-247. Trenerry, M.R., Crosson, B., DeBoe, J. et al. (1989) Stroop Neuropsychological Screening Test. Psychological Assessment Resources, Odessa. Walsh, A.J., Lebel, R.M., Eissa, A. et al. (2013) Multiple sclerosis: validation of MR imaging for quantification and detection of iron. Radiology, 267, 531-542. Brevers, D., Bechara, A., Cleeremans, A. et al. (2013) Iowa Gambling Task (IGT): twenty years after gambling disorder and IGT. Frontiers in Psychology, 4, 1-14. Schneider, A.L., Sharrett, A.R., Gottesman, R.F. et al. (2015) Normative data for 8 neuropsychological tests in older blacks and whites from the atherosclerosis risk in communities (ARIC) study. Alzheimer Disease and Associated Disorders, 29, 32-44. Delis, D.C., Kramer, J.H., Kaplan, E. et al. (2000) California Verbal Learning Test, 2nd edn. Psychological Corporation, San Antonio, TX. Pfefferbaum, A., Adalsteinsson, E., Rohlfing, T. et al. (2010) Diffusion tensor imaging of deep gray matter brain structures: effects of age and iron concentration. Neurobiology Aging, 3, 482-493. Movahed, A., Larijani, B., Nabipour, I. et al. (2012) Reduced serum osteocalcin concentrations are associated with type 2 diabetes mellitus and the metabolic syndrome components in postmenopausal women: the crosstalk between bone and energy metabolism. Journal of Bone and Mineral Metabolism, 30, 683-691. Tricomi, E.M., Delgado, M.R. & Fiez, J.A. (2004) Modulation of caudate activity by action contingency. Neuron, 41, 281-292. Lee, A.J., Hodges, S. & Eastell, R. (2000) Measurement of osteocalcin. Annals of Clinical Biochemistry, 37, 432-446. Friendly, M., Monette, G. & Fox, J. (2013) Elliptical insights: understanding statistical methods through elliptical geometry. Statistical Science, 28, 1-39. Bartzokis, G., Aravagiri, M., Oldendorf, W.H. et al. (1993) Field dependent transverse relaxation rate increase may be a specific measure of tissue iron stores. Magnetic Resonance in Medicine, 29, 459-464. Otto, F., Kanegane, H. & Mundlos, S. (2002) Mutations in the RUNX2 gene in patients with cleidocranial dysplasia. Human Mutation, 19, 209-216. Shin, M.S., Park, S.Y., Park, S.R. et al. (2006) Clinical and empirical applications of the Rey-Osterrieth Complex Figure Test. Nature Protocols, 1, 892-899. Montague, P.R., Berns, G.S., Cohen, J.D. et al. (2002) Hyperscanning: simultaneous fMRI during linked social interactions. NeuroImage, 16, 1159-1164. Grahn, J.A., Parkinson, J.A. & Owen, A.M. (2008) The cognitive functions of the caudate nucleus. Progress in Neurobiology, 86, 141-155. 2002; 16 2004; 41 2002; 15 2010; 31 2013; 4 1993; 29 2013; 28 2002; 19 2012 2006; 11 2013; 62 2013; 267 2012; 18 2006; 1 1975; 72 2012; 30 2015; 29 2000; 37 2000 2009; 71 2013; 78 2008; 29 2007; 130 2013; 155 2014; 37 2006; 29 2014; 35 2005; 308 2008; 86 2010; 3 2012; 4 1989 Delis D.C. (e_1_2_6_17_1) 2000 e_1_2_6_32_1 e_1_2_6_10_1 e_1_2_6_31_1 e_1_2_6_30_1 Bezerra Santos dos Magalhães K. (e_1_2_6_7_1) 2013; 62 Lee A.J. (e_1_2_6_3_1) 2000; 37 Lezak M. (e_1_2_6_16_1) 2012 e_1_2_6_19_1 e_1_2_6_13_1 e_1_2_6_14_1 e_1_2_6_11_1 e_1_2_6_12_1 e_1_2_6_33_1 e_1_2_6_18_1 e_1_2_6_15_1 e_1_2_6_21_1 e_1_2_6_9_1 Trenerry M.R. (e_1_2_6_20_1) 1989 e_1_2_6_8_1 e_1_2_6_5_1 e_1_2_6_4_1 e_1_2_6_6_1 e_1_2_6_25_1 e_1_2_6_24_1 e_1_2_6_23_1 e_1_2_6_2_1 e_1_2_6_22_1 e_1_2_6_29_1 e_1_2_6_28_1 e_1_2_6_27_1 e_1_2_6_26_1 |
| References_xml | – volume: 29 start-page: 417 year: 2006 end-page: 448 article-title: Imaging valuation models in human choice publication-title: Annual Review of Neuroscience – volume: 37 start-page: 3076 year: 2014 end-page: 3083 article-title: Brain iron overload, insulin resistance, and cognitive performance in obese subjects: a preliminary MRI case–control study publication-title: Diabetes Care – volume: 267 start-page: 531 year: 2013 end-page: 542 article-title: Multiple sclerosis: validation of MR imaging for quantification and detection of iron publication-title: Radiology – volume: 35 start-page: 2203 year: 2014 end-page: 2216 article-title: Aging in deep gray matter and white matter revealed by diffusional kurtosis imaging publication-title: Neurobiology of Aging – volume: 37 start-page: 432 year: 2000 end-page: 446 article-title: Measurement of osteocalcin publication-title: Annals of Clinical Biochemistry – volume: 16 start-page: 1159 year: 2002 end-page: 1164 article-title: Hyperscanning: simultaneous fMRI during linked social interactions publication-title: NeuroImage – volume: 62 start-page: 181 year: 2013 end-page: 186 article-title: Metabolic syndrome and central fat distribution are related to lower serum osteocalcin concentrations publication-title: Annals of Nutrition and Metabolism – volume: 29 start-page: 32 year: 2015 end-page: 44 article-title: Normative data for 8 neuropsychological tests in older blacks and whites from the atherosclerosis risk in communities (ARIC) study publication-title: Alzheimer Disease and Associated Disorders – volume: 3 start-page: 482 year: 2010 end-page: 493 article-title: Diffusion tensor imaging of deep gray matter brain structures: effects of age and iron concentration publication-title: Neurobiology Aging – volume: 4 start-page: 1 year: 2013 end-page: 14 article-title: Iowa Gambling Task (IGT): twenty years after gambling disorder and IGT publication-title: Frontiers in Psychology – volume: 1 start-page: 892 year: 2006 end-page: 899 article-title: Clinical and empirical applications of the Rey‐Osterrieth Complex Figure Test publication-title: Nature Protocols – year: 1989 – volume: 31 start-page: 482 year: 2010 end-page: 493 article-title: Diffusion tensor imaging of deep gray matter brain structures: effects of age and iron concentration publication-title: Neurobiology of Aging – volume: 18 start-page: 758 year: 2012 end-page: 762 article-title: Bone as an endocrine organ publication-title: Endocrine Practice – year: 2000 – volume: 72 start-page: 3925 year: 1975 end-page: 3929 article-title: Direct identification of the calcium‐binding amino acid, γ‐carboxyglutamate, in mineralized tissue publication-title: Proceedings of the National Academy of Sciences of the United States of America – year: 2012 – volume: 28 start-page: 1 year: 2013 end-page: 39 article-title: Elliptical insights: understanding statistical methods through elliptical geometry publication-title: Statistical Science – volume: 86 start-page: 141 year: 2008 end-page: 155 article-title: The cognitive functions of the caudate nucleus publication-title: Progress in Neurobiology – volume: 155 start-page: 228 year: 2013 end-page: 241 article-title: Maternal and offspring pools of osteocalcin influence brain development and functions publication-title: Cell – volume: 29 start-page: 632 year: 2008 end-page: 641 article-title: Diffusion tensor MR imaging and fiber tractography: theoretic underpinnings publication-title: American Journal of Neuroradiology – volume: 130 start-page: 456 year: 2007 end-page: 469 article-title: Endocrine regulation of energy metabolism by the skeleton publication-title: Cell – volume: 71 start-page: 437 year: 2009 end-page: 451 article-title: The Wisconsin Card Sorting Test and the cognitive assessment of prefrontal executive functions: a critical update publication-title: Brain and Cognition – volume: 19 start-page: 209 year: 2002 end-page: 216 article-title: Mutations in the RUNX2 gene in patients with cleidocranial dysplasia publication-title: Human Mutation – volume: 308 start-page: 78 year: 2005 end-page: 83 article-title: Getting to know you: reputation and trust in a two‐person economic exchange publication-title: Science – volume: 30 start-page: 683 year: 2012 end-page: 691 article-title: Reduced serum osteocalcin concentrations are associated with type 2 diabetes mellitus and the metabolic syndrome components in postmenopausal women: the crosstalk between bone and energy metabolism publication-title: Journal of Bone and Mineral Metabolism – volume: 11 start-page: 445 year: 2006 end-page: 456 article-title: The management of ADHD and associated problems in a young person with cleidocranial dysostosis (CCD) and mild intellectual disability publication-title: Clinical Child Psychology and Psychiatry – volume: 41 start-page: 281 year: 2004 end-page: 292 article-title: Modulation of caudate activity by action contingency publication-title: Neuron – volume: 4 start-page: 199 year: 2012 end-page: 203 article-title: The Bayesian information criterion: background, derivation, and applications publication-title: WIREs Computational Statistics – volume: 78 start-page: 242 year: 2013 end-page: 247 article-title: Osteocalcin as a predictor of the metabolic syndrome in older persons: a population‐based study publication-title: Clinical Endocrinology – volume: 29 start-page: 459 year: 1993 end-page: 464 article-title: Field dependent transverse relaxation rate increase may be a specific measure of tissue iron stores publication-title: Magnetic Resonance in Medicine – volume: 15 start-page: 435 year: 2002 end-page: 455 article-title: The basis of anisotropic water diffusion in the nervous system – a technical review publication-title: NMR in Biomedicine – ident: e_1_2_6_14_1 doi: 10.1016/j.neurobiolaging.2014.03.011 – ident: e_1_2_6_21_1 doi: 10.3389/fpsyg.2013.00665 – ident: e_1_2_6_31_1 doi: 10.1016/j.neurobiolaging.2008.04.013 – ident: e_1_2_6_5_1 doi: 10.1016/j.cell.2007.05.047 – ident: e_1_2_6_10_1 doi: 10.1177/1359104506059127 – ident: e_1_2_6_19_1 doi: 10.1097/WAD.0000000000000042 – volume: 37 start-page: 432 year: 2000 ident: e_1_2_6_3_1 article-title: Measurement of osteocalcin publication-title: Annals of Clinical Biochemistry doi: 10.1177/000456320003700402 contributor: fullname: Lee A.J. – volume-title: California Verbal Learning Test year: 2000 ident: e_1_2_6_17_1 contributor: fullname: Delis D.C. – ident: e_1_2_6_29_1 doi: 10.1016/S0896-6273(03)00848-1 – ident: e_1_2_6_13_1 doi: 10.1002/nbm.782 – ident: e_1_2_6_12_1 doi: 10.3174/ajnr.A1051 – ident: e_1_2_6_26_1 doi: 10.1006/nimg.2002.1150 – ident: e_1_2_6_2_1 doi: 10.1073/pnas.72.10.3925 – ident: e_1_2_6_15_1 doi: 10.2337/dc14-0664 – ident: e_1_2_6_18_1 doi: 10.1038/nprot.2006.115 – volume-title: Stroop Neuropsychological Screening Test year: 1989 ident: e_1_2_6_20_1 contributor: fullname: Trenerry M.R. – ident: e_1_2_6_33_1 doi: 10.1111/j.1365-2265.2012.04391.x – ident: e_1_2_6_27_1 doi: 10.1126/science.1108062 – ident: e_1_2_6_4_1 doi: 10.4158/EP12141.RA – ident: e_1_2_6_11_1 doi: 10.1016/j.neurobiolaging.2008.04.013 – ident: e_1_2_6_24_1 doi: 10.1002/wics.199 – ident: e_1_2_6_8_1 doi: 10.1016/j.cell.2013.08.042 – ident: e_1_2_6_28_1 doi: 10.1146/annurev.neuro.29.051605.112903 – ident: e_1_2_6_22_1 doi: 10.1016/j.bandc.2009.03.005 – ident: e_1_2_6_30_1 doi: 10.1002/mrm.1910290406 – ident: e_1_2_6_25_1 doi: 10.1016/j.pneurobio.2008.09.004 – ident: e_1_2_6_32_1 doi: 10.1148/radiol.12120863 – ident: e_1_2_6_9_1 doi: 10.1002/humu.10043 – ident: e_1_2_6_6_1 doi: 10.1007/s00774-012-0367-z – volume: 62 start-page: 181 year: 2013 ident: e_1_2_6_7_1 article-title: Metabolic syndrome and central fat distribution are related to lower serum osteocalcin concentrations publication-title: Annals of Nutrition and Metabolism contributor: fullname: Bezerra Santos dos Magalhães K. – ident: e_1_2_6_23_1 doi: 10.1214/12-STS402 – volume-title: Neuropsychological Assessment year: 2012 ident: e_1_2_6_16_1 contributor: fullname: Lezak M. |
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Rodent models have found that osteocalcin crosses the blood–brain barrier and regulates behaviour. No data are available on osteocalcin's... Rodent models have found that osteocalcin crosses the blood-brain barrier and regulates behaviour. No data are available on osteocalcin's effects on brain... Summary Objective Rodent models have found that osteocalcin crosses the blood-brain barrier and regulates behaviour. No data are available on osteocalcin's... OBJECTIVERodent models have found that osteocalcin crosses the blood-brain barrier and regulates behaviour. No data are available on osteocalcin's effects on... Objective Rodent models have found that osteocalcin crosses the blood-brain barrier and regulates behaviour. No data are available on osteocalcin's effects on... |
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| SubjectTerms | Adult Anisotropy Bayes Theorem Body Mass Index Brain - pathology Brain - physiopathology Cognition - physiology Cross-Sectional Studies Female Humans Magnetic Resonance Imaging Male Middle Aged Multivariate Analysis Neuropsychological Tests NMR Nuclear magnetic resonance Obesity - blood Obesity - physiopathology Obesity - psychology Osteocalcin - blood Predictive Value of Tests |
| Title | Lower serum osteocalcin concentrations are associated with brain microstructural changes and worse cognitive performance |
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