Overload of the Temporomandibular Joints Accumulates γδ T Cells in a Mouse Model of Rheumatoid Arthritis: A Morphological and Histological Evaluation
Recently, it has been reported that γδ T cells are associated with the pathology of rheumatoid arthritis (RA). However, there are many uncertainties about their relationship. In this study, we investigated the morphological and histological properties of peripheral as well as temporomandibular joint...
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Published in | Frontiers in immunology Vol. 12; p. 753754 |
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Abstract | Recently, it has been reported that γδ T cells are associated with the pathology of rheumatoid arthritis (RA). However, there are many uncertainties about their relationship. In this study, we investigated the morphological and histological properties of peripheral as well as temporomandibular joints (TMJ) in a mouse model of rheumatoid arthritis with and without exposure to mechanical strain on the TMJ. Collagen antibody-induced arthritis (CAIA) was induced by administering collagen type II antibody and lipopolysaccharide to male DBA/1JNCrlj mice at 9-12 weeks of age, and mechanical stress (MS) was applied to the mandibular condyle. After 14 days, 3D morphological evaluation by micro-CT, histological staining (Hematoxylin Eosin, Safranin O, and Tartrate-Resistant Acid Phosphatase staining), and immunohistochemical staining (ADAMTS-5 antibody, CD3 antibody, CD45 antibody, RORγt antibody, γδ T cell receptor antibody) were performed. The lower jawbone was collected. The mandibular condyle showed a rough change in the surface of the mandibular condyle based on three-dimensional analysis by micro-CT imaging. Histological examination revealed bone and cartilage destruction, such as a decrease in chondrocyte layer width and an increase in the number of osteoclasts in the mandibular condyle. Then, immune-histological staining revealed accumulation of T and γδ T cells in the subchondral bone. The temporomandibular joint is less sensitive to the onset of RA, but it has been suggested that it is exacerbated by mechanical stimulation. Additionally, the involvement of γδ T cells was suggested as the etiology of rheumatoid arthritis. |
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AbstractList | Recently, it has been reported that γδ T cells are associated with the pathology of rheumatoid arthritis (RA). However, there are many uncertainties about their relationship. In this study, we investigated the morphological and histological properties of peripheral as well as temporomandibular joints (TMJ) in a mouse model of rheumatoid arthritis with and without exposure to mechanical strain on the TMJ. Collagen antibody-induced arthritis (CAIA) was induced by administering collagen type II antibody and lipopolysaccharide to male DBA/1JNCrlj mice at 9−12 weeks of age, and mechanical stress (MS) was applied to the mandibular condyle. After 14 days, 3D morphological evaluation by micro-CT, histological staining (Hematoxylin Eosin, Safranin O, and Tartrate-Resistant Acid Phosphatase staining), and immunohistochemical staining (ADAMTS-5 antibody, CD3 antibody, CD45 antibody, RORγt antibody, γδ T cell receptor antibody) were performed. The lower jawbone was collected. The mandibular condyle showed a rough change in the surface of the mandibular condyle based on three-dimensional analysis by micro-CT imaging. Histological examination revealed bone and cartilage destruction, such as a decrease in chondrocyte layer width and an increase in the number of osteoclasts in the mandibular condyle. Then, immune-histological staining revealed accumulation of T and γδ T cells in the subchondral bone. The temporomandibular joint is less sensitive to the onset of RA, but it has been suggested that it is exacerbated by mechanical stimulation. Additionally, the involvement of γδ T cells was suggested as the etiology of rheumatoid arthritis. Recently, it has been reported that γδ T cells are associated with the pathology of rheumatoid arthritis (RA). However, there are many uncertainties about their relationship. In this study, we investigated the morphological and histological properties of peripheral as well as temporomandibular joints (TMJ) in a mouse model of rheumatoid arthritis with and without exposure to mechanical strain on the TMJ. Collagen antibody-induced arthritis (CAIA) was induced by administering collagen type II antibody and lipopolysaccharide to male DBA/1JNCrlj mice at 9-12 weeks of age, and mechanical stress (MS) was applied to the mandibular condyle. After 14 days, 3D morphological evaluation by micro-CT, histological staining (Hematoxylin Eosin, Safranin O, and Tartrate-Resistant Acid Phosphatase staining), and immunohistochemical staining (ADAMTS-5 antibody, CD3 antibody, CD45 antibody, RORγt antibody, γδ T cell receptor antibody) were performed. The lower jawbone was collected. The mandibular condyle showed a rough change in the surface of the mandibular condyle based on three-dimensional analysis by micro-CT imaging. Histological examination revealed bone and cartilage destruction, such as a decrease in chondrocyte layer width and an increase in the number of osteoclasts in the mandibular condyle. Then, immune-histological staining revealed accumulation of T and γδ T cells in the subchondral bone. The temporomandibular joint is less sensitive to the onset of RA, but it has been suggested that it is exacerbated by mechanical stimulation. Additionally, the involvement of γδ T cells was suggested as the etiology of rheumatoid arthritis. |
Author | Ishii, Takenobu Nagai, Kohei Ohno, Tatsukuni Nishii, Yasushi |
AuthorAffiliation | 2 Oral Health Science Center, Tokyo Dental College , Tokyo , Japan 1 Department of Orthodontics, Tokyo Dental College , Tokyo , Japan 3 Tokyo Dental College Research Branding Project, Tokyo Dental College , Tokyo , Japan |
AuthorAffiliation_xml | – name: 3 Tokyo Dental College Research Branding Project, Tokyo Dental College , Tokyo , Japan – name: 2 Oral Health Science Center, Tokyo Dental College , Tokyo , Japan – name: 1 Department of Orthodontics, Tokyo Dental College , Tokyo , Japan |
Author_xml | – sequence: 1 givenname: Kohei surname: Nagai fullname: Nagai, Kohei organization: Department of Orthodontics, Tokyo Dental College, Tokyo, Japan – sequence: 2 givenname: Takenobu surname: Ishii fullname: Ishii, Takenobu organization: Department of Orthodontics, Tokyo Dental College, Tokyo, Japan – sequence: 3 givenname: Tatsukuni surname: Ohno fullname: Ohno, Tatsukuni organization: Tokyo Dental College Research Branding Project, Tokyo Dental College, Tokyo, Japan – sequence: 4 givenname: Yasushi surname: Nishii fullname: Nishii, Yasushi organization: Department of Orthodontics, Tokyo Dental College, Tokyo, Japan |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35069529$$D View this record in MEDLINE/PubMed |
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Cites_doi | 10.1016/j.joca.2016.11.008 10.4049/jimmunol.169.3.1459 10.1016/j.intimp.2007.05.021 10.1186/s13075-015-0703-5 10.1093/rheumatology/keh202 10.3390/polym10121384 10.1371/journal.pone.0135409 10.4049/jimmunol.148.7.2103 10.1016/j.joca.2015.07.022 10.1016/j.bbrc.2010.02.086 10.1186/ar1217 10.1016/S1726-4901(08)70055-8 10.1016/j.joca.2013.11.014 10.1016/S0140-6736(16)30173-8 10.3892/etm.2015.2629 10.1186/s13075-016-1084-0 10.18632/oncotarget.13051 10.1016/j.archoralbio.2014.08.010 10.3390/cells9020462 10.1016/j.archoralbio.2019.05.032 10.1177/0300985815588612 10.1016/j.jbspin.2016.05.016 10.1038/s41368-019-0072-z 10.3899/jrheum.141416 10.1016/j.jim.2005.06.017 10.3892/mmr.2019.9831 10.1016/j.joca.2011.01.012 10.1146/annurev.immunol.25.022106.141557 10.1007/s12263-009-0144-3 10.1038/nm.3085 10.1210/en.2003-1536 10.3109/00016357.2014.994561 10.1038/s41467-018-06933-4 10.1111/1756-185X.13486 10.3389/fimmu.2018.01057 10.4049/jimmunol.179.8.5576 |
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Keywords | CAIA mechanical stress temporomandibular joint rheumatoid arthritis γδ T cell |
Language | English |
License | Copyright © 2022 Nagai, Ishii, Ohno and Nishii. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
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Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Edited by: Marco Erreni, Humanitas Research Hospital, Italy These authors have contributed equally to this work This article was submitted to Inflammation, a section of the journal Frontiers in Immunology Reviewed by: Stephanie Finzel, University of Freiburg, Germany; Jianhai Chen, Shenzhen Institutes of Advanced Technology (CAS), China |
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SubjectTerms | Animals Arthritis, Experimental - immunology Arthritis, Experimental - pathology Arthritis, Rheumatoid - immunology Arthritis, Rheumatoid - pathology CAIA Immunology Male mechanical stress Mice Receptors, Antigen, T-Cell, gamma-delta - immunology rheumatoid arthritis T-Lymphocytes - immunology T-Lymphocytes - pathology temporomandibular joint Temporomandibular Joint - immunology Temporomandibular Joint - pathology γδ T cell |
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Title | Overload of the Temporomandibular Joints Accumulates γδ T Cells in a Mouse Model of Rheumatoid Arthritis: A Morphological and Histological Evaluation |
URI | https://www.ncbi.nlm.nih.gov/pubmed/35069529 https://search.proquest.com/docview/2622475241 https://pubmed.ncbi.nlm.nih.gov/PMC8771909 https://doaj.org/article/08352001ec1b48ceb7d92dd32470022c |
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