Direct stimulatory effect of insulin-like growth factor-I on monocyte and macrophage tumor necrosis factor-alpha production

• Published in: Endocrinology (Philadelphia) Vol. 137; no. 11; p. 4611
• Main Authors: Renier, G, Clément, I, Desfaits, A C, Lambert, A
• Format: Journal Article
• Language: English
• Published: United States 01.11.1996
• Subjects: Animals; Cell Line; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors - pharmacology; Genistein; Growth Hormone - pharmacology; Humans; Insulin-Like Growth Factor I - pharmacology; Insulin-Like Growth Factor II - pharmacology; Isoflavones - pharmacology; Kinetics; Lipopolysaccharides - pharmacology; Macrophages - cytology; Macrophages - drug effects; Macrophages - physiology; Mice; Mice, Inbred C57BL; Monocytes - cytology; Monocytes - drug effects; Monocytes - physiology; Protein-Tyrosine Kinases - antagonists & inhibitors; RNA, Messenger - biosynthesis; Transcription, Genetic - drug effects; Tumor Necrosis Factor-alpha - biosynthesis
• ISSN: 0013-7227
• DOI: 10.1210/endo.137.11.8895324

GH has been demonstrated to play a physiological role in the priming of macrophages for tumor necrosis factor-alpha (TNF alpha) synthesis. Although evidence has been presented that GH exerts this effect by an indirect mechanism, the mediators of GH stimulation of TNF alpha synthesis have not been id...