Differential requirement of Hippo cascade during CTNNB1 or AXIN1 mutation-driven hepatocarcinogenesis

• Published in: Hepatology (Baltimore, Md.) Vol. 77; no. 6; pp. 1929 - 1942
• Main Authors: Liang, Binyong, Wang, Haichuan, Qiao, Yu, Wang, Xue, Qian, Manning, Song, Xinhua, Zhou, Yi, Zhang, Yi, Shang, Runze, Che, Li, Chen, Yifa, Huang, Zhiyong, Wu, Hong, Monga, Satdarshan P., Zeng, Yong, Calvisi, Diego F., Chen, Xiaoping, Chen, Xin
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 01.06.2023
• Subjects: Animals; Axin Protein - genetics; beta Catenin - genetics; Carcinogenesis - genetics; Carcinoma, Hepatocellular - pathology; Humans; Liver Neoplasms - pathology; Mice; Mutation; Protein Serine-Threonine Kinases - metabolism; Tumor Suppressor Proteins - metabolism; Wnt Signaling Pathway - genetics

Background and Aims: Gain-of-function (GOF) mutations of CTNNB1 and loss-of-function (LOF) mutations of AXIN1 are recurrent genetic alterations in hepatocellular carcinoma (HCC). We aim to investigate the functional contribution of Hippo/YAP/TAZ in GOF CTNNB1 or LOF AXIN1 mutant HCCs. Approach and R...