Biochemical investigation and gene expression analysis of the immunostimulatory functions of an edible Salacia extract in rat small intestine
Roots and bark from plants belonging to genus Salacia of the family Hippocrateaceae (Salacia reticulata, Salacia oblonga, etc.) have been used for traditional Ayurvedic medicine, particularly for the treatment of diabetes. In our study, we evaluated the gene expression profiles in the small intestin...
Saved in:
Published in | BioFactors (Oxford) Vol. 37; no. 1; pp. 31 - 39 |
---|---|
Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Hoboken
Wiley Subscription Services, Inc., A Wiley Company
01.01.2011
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | Roots and bark from plants belonging to genus Salacia of the family Hippocrateaceae (Salacia reticulata, Salacia oblonga, etc.) have been used for traditional Ayurvedic medicine, particularly for the treatment of diabetes. In our study, we evaluated the gene expression profiles in the small intestinal epithelium of rats that were given a Salacia plant extract to gain insight into its effects on the small intestine. In detail, DNA microarray analysis was performed to evaluate the gene expression profiles in the rat ileal epithelium. The intestinal bacterial flora was also studied using T‐RFLP (Nagashima method) in these rats. Expressions of many immune‐related genes, especially Th1‐related genes associated with cell‐mediated immunity, were found to increase in the small intestinal epithelium and the intestinal bacterial flora became similar to those in the case with Salacia plant extract administration. Our study thus revealed that Salacia plant extract exerts bioregulatory functions by boosting intestinal immunity. |
---|---|
Bibliography: | istex:E39D2CCD2E7B80DB1D425BCD1F0675B13BCD3A94 ArticleID:BIOF132 ark:/67375/WNG-MJ51RJK7-G Tel.:+81‐465‐86‐1019; Fax.:+81‐465‐86‐1019 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0951-6433 1872-8081 |
DOI: | 10.1002/biof.132 |