Predicting subsequent relapse by drug-related cue-induced brain activation in heroin addiction: an event-related functional magnetic resonance imaging study

Abnormal salience attribution is implicated in heroin addiction. Previously, combining functional magnetic resonance imaging (fMRI) and a drug cue‐reactivity task, we demonstrated abnormal patterns of subjective response and brain reactivity in heroin‐dependent individuals. However, whether the chan...

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Published inAddiction biology Vol. 20; no. 5; pp. 968 - 978
Main Authors Li, Qiang, Li, Wei, Wang, Hanyue, Wang, Yarong, Zhang, Yi, Zhu, Jia, Zheng, Ying, Zhang, Dongsheng, Wang, Lina, Li, Yongbin, Yan, Xuejiao, Chang, Haifeng, Fan, Min, Li, Zhe, Tian, Jie, Gold, Mark S., Wang, Wei, Liu, Yijun
Format Journal Article
LanguageEnglish
Published United States Blackwell Publishing Ltd 01.09.2015
John Wiley & Sons, Inc
Subjects
Adult
Brain - drug effects
Brain - physiopathology
Brain Mapping
China
Craving
Cues
Female
fMRI
Follow-Up Studies
heroin addiction
Heroin Dependence - physiopathology
Heroin Dependence - rehabilitation
History, Ancient
Humans
Magnetic Resonance Imaging
Male
Methadone - therapeutic use
Opiate Substitution Treatment
Predictive Value of Tests
Prospective Studies
Recurrence
relapse
Reproducibility of Results
China
fMRI
heroin addiction
relapse
Craving
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Abstract Abnormal salience attribution is implicated in heroin addiction. Previously, combining functional magnetic resonance imaging (fMRI) and a drug cue‐reactivity task, we demonstrated abnormal patterns of subjective response and brain reactivity in heroin‐dependent individuals. However, whether the changes in cue‐induced brain response were related to relapse was unknown. In a prospective study, we recruited 49 heroin‐dependent patients under methadone maintenance treatment, a gold standard treatment (average daily dose 41.8 ± 16.0 mg), and 20 healthy subjects to perform the heroin cue‐reactivity task during fMRI. The patients' subjective craving was evaluated. They participated in a follow‐up assessment for 3 months, during which heroin use was assessed and relapse was confirmed by self‐reported relapse or urine toxicology. Differences between relapsers and non‐relapsers were analyzed with respect to the results from heroin‐cue responses. Compared with healthy subjects, relapsers and non‐relapsers commonly demonstrated significantly increased brain responses during the processing of heroin cues in the mesolimbic system, prefrontal regions and visuospatial‐attention regions. However, compared with non‐relapsers, relapsers demonstrated significantly greater cue‐induced craving and the brain response mainly in the bilateral nucleus accumbens/subcallosal cortex and cerebellum. Although the cue‐induced heroin craving was low in absolute measures, the change in craving positively correlated with the activation of the nucleus accumbens/subcallosal cortex among the patients. These findings suggest that in treatment‐seeking heroin‐dependent individuals, greater cue‐induced craving and greater specific regional activations might be related to reward/craving and memory retrieval processes. These responses may predict relapse and represent important targets for the development of new treatment for heroin addiction. Whether abnormal salience attribution is related to relapse to heroin use was unknown. In a 3‐month follow‐up prospective cue response fMRI study, we found that compared with nonrelapsers, relapsers demonstrated significantly greater cue‐induced craving and the brain response mainly in the bilateral nucleus accumbens/subcallosal cortex and cerebellum. These findings suggest that, greater cue‐induced craving and activations in reward/craving and memory retrieval related regions may predict relapse and represent important targets for the development of new treatment for heroin addiction.
AbstractList Abnormal salience attribution is implicated in heroin addiction. Previously, combining functional magnetic resonance imaging (fMRI) and a drug cue-reactivity task, we demonstrated abnormal patterns of subjective response and brain reactivity in heroin-dependent individuals. However, whether the changes in cue-induced brain response were related to relapse was unknown. In a prospective study, we recruited 49 heroin-dependent patients under methadone maintenance treatment, a gold standard treatment (average daily dose 41.8±16.0mg), and 20 healthy subjects to perform the heroin cue-reactivity task during fMRI. The patients' subjective craving was evaluated. They participated in a follow-up assessment for 3 months, during which heroin use was assessed and relapse was confirmed by self-reported relapse or urine toxicology. Differences between relapsers and non-relapsers were analyzed with respect to the results from heroin-cue responses. Compared with healthy subjects, relapsers and non-relapsers commonly demonstrated significantly increased brain responses during the processing of heroin cues in the mesolimbic system, prefrontal regions and visuospatial-attention regions. However, compared with non-relapsers, relapsers demonstrated significantly greater cue-induced craving and the brain response mainly in the bilateral nucleus accumbens/subcallosal cortex and cerebellum. Although the cue-induced heroin craving was low in absolute measures, the change in craving positively correlated with the activation of the nucleus accumbens/subcallosal cortex among the patients. These findings suggest that in treatment-seeking heroin-dependent individuals, greater cue-induced craving and greater specific regional activations might be related to reward/craving and memory retrieval processes. These responses may predict relapse and represent important targets for the development of new treatment for heroin addiction.
Abnormal salience attribution is implicated in heroin addiction. Previously, combining functional magnetic resonance imaging (fMRI) and a drug cue-reactivity task, we demonstrated abnormal patterns of subjective response and brain reactivity in heroin-dependent individuals. However, whether the changes in cue-induced brain response were related to relapse was unknown. In a prospective study, we recruited 49 heroin-dependent patients under methadone maintenance treatment, a gold standard treatment (average daily dose 41.8 ± 16.0 mg), and 20 healthy subjects to perform the heroin cue-reactivity task during fMRI. The patients' subjective craving was evaluated. They participated in a follow-up assessment for 3 months, during which heroin use was assessed and relapse was confirmed by self-reported relapse or urine toxicology. Differences between relapsers and non-relapsers were analyzed with respect to the results from heroin-cue responses. Compared with healthy subjects, relapsers and non-relapsers commonly demonstrated significantly increased brain responses during the processing of heroin cues in the mesolimbic system, prefrontal regions and visuospatial-attention regions. However, compared with non-relapsers, relapsers demonstrated significantly greater cue-induced craving and the brain response mainly in the bilateral nucleus accumbens/subcallosal cortex and cerebellum. Although the cue-induced heroin craving was low in absolute measures, the change in craving positively correlated with the activation of the nucleus accumbens/subcallosal cortex among the patients. These findings suggest that in treatment-seeking heroin-dependent individuals, greater cue-induced craving and greater specific regional activations might be related to reward/craving and memory retrieval processes. These responses may predict relapse and represent important targets for the development of new treatment for heroin addiction.
Abnormal salience attribution is implicated in heroin addiction. Previously, combining functional magnetic resonance imaging ( fMRI ) and a drug cue‐reactivity task, we demonstrated abnormal patterns of subjective response and brain reactivity in heroin‐dependent individuals. However, whether the changes in cue‐induced brain response were related to relapse was unknown. In a prospective study, we recruited 49 heroin‐dependent patients under methadone maintenance treatment, a gold standard treatment (average daily dose 41.8 ± 16.0 mg), and 20 healthy subjects to perform the heroin cue‐reactivity task during fMRI . The patients' subjective craving was evaluated. They participated in a follow‐up assessment for 3 months, during which heroin use was assessed and relapse was confirmed by self‐reported relapse or urine toxicology. Differences between relapsers and non‐relapsers were analyzed with respect to the results from heroin‐cue responses. Compared with healthy subjects, relapsers and non‐relapsers commonly demonstrated significantly increased brain responses during the processing of heroin cues in the mesolimbic system, prefrontal regions and visuospatial‐attention regions. However, compared with non‐relapsers, relapsers demonstrated significantly greater cue‐induced craving and the brain response mainly in the bilateral nucleus accumbens/subcallosal cortex and cerebellum. Although the cue‐induced heroin craving was low in absolute measures, the change in craving positively correlated with the activation of the nucleus accumbens/subcallosal cortex among the patients. These findings suggest that in treatment‐seeking heroin‐dependent individuals, greater cue‐induced craving and greater specific regional activations might be related to reward/craving and memory retrieval processes. These responses may predict relapse and represent important targets for the development of new treatment for heroin addiction.
Abnormal salience attribution is implicated in heroin addiction. Previously, combining functional magnetic resonance imaging (fMRI) and a drug cue-reactivity task, we demonstrated abnormal patterns of subjective response and brain reactivity in heroin-dependent individuals. However, whether the changes in cue-induced brain response were related to relapse was unknown. In a prospective study, we recruited 49 heroin-dependent patients under methadone maintenance treatment, a gold standard treatment (average daily dose 41.8 plus or minus 16.0mg), and 20 healthy subjects to perform the heroin cue-reactivity task during fMRI. The patients' subjective craving was evaluated. They participated in a follow-up assessment for 3 months, during which heroin use was assessed and relapse was confirmed by self-reported relapse or urine toxicology. Differences between relapsers and non-relapsers were analyzed with respect to the results from heroin-cue responses. Compared with healthy subjects, relapsers and non-relapsers commonly demonstrated significantly increased brain responses during the processing of heroin cues in the mesolimbic system, prefrontal regions and visuospatial-attention regions. However, compared with non-relapsers, relapsers demonstrated significantly greater cue-induced craving and the brain response mainly in the bilateral nucleus accumbens/subcallosal cortex and cerebellum. Although the cue-induced heroin craving was low in absolute measures, the change in craving positively correlated with the activation of the nucleus accumbens/subcallosal cortex among the patients. These findings suggest that in treatment-seeking heroin-dependent individuals, greater cue-induced craving and greater specific regional activations might be related to reward/craving and memory retrieval processes. These responses may predict relapse and represent important targets for the development of new treatment for heroin addiction. Whether abnormal salience attribution is related to relapse to heroin use was unknown. In a 3-month follow-up prospective cue response fMRI study, we found that compared with nonrelapsers, relapsers demonstrated significantly greater cue-induced craving and the brain response mainly in the bilateral nucleus accumbens/subcallosal cortex and cerebellum. These findings suggest that, greater cue-induced craving and activations in reward/craving and memory retrieval related regions may predict relapse and represent important targets for the development of new treatment for heroin addiction.
Abnormal salience attribution is implicated in heroin addiction. Previously, combining functional magnetic resonance imaging (fMRI) and a drug cue-reactivity task, we demonstrated abnormal patterns of subjective response and brain reactivity in heroin-dependent individuals. However, whether the changes in cue-induced brain response were related to relapse was unknown. In a prospective study, we recruited 49 heroin-dependent patients under methadone maintenance treatment, a gold standard treatment (average daily dose 41.8 ± 16.0 mg), and 20 healthy subjects to perform the heroin cue-reactivity task during fMRI. The patients' subjective craving was evaluated. They participated in a follow-up assessment for 3 months, during which heroin use was assessed and relapse was confirmed by self-reported relapse or urine toxicology. Differences between relapsers and non-relapsers were analyzed with respect to the results from heroin-cue responses. Compared with healthy subjects, relapsers and non-relapsers commonly demonstrated significantly increased brain responses during the processing of heroin cues in the mesolimbic system, prefrontal regions and visuospatial-attention regions. However, compared with non-relapsers, relapsers demonstrated significantly greater cue-induced craving and the brain response mainly in the bilateral nucleus accumbens/subcallosal cortex and cerebellum. Although the cue-induced heroin craving was low in absolute measures, the change in craving positively correlated with the activation of the nucleus accumbens/subcallosal cortex among the patients. These findings suggest that in treatment-seeking heroin-dependent individuals, greater cue-induced craving and greater specific regional activations might be related to reward/craving and memory retrieval processes. These responses may predict relapse and represent important targets for the development of new treatment for heroin addiction.Abnormal salience attribution is implicated in heroin addiction. Previously, combining functional magnetic resonance imaging (fMRI) and a drug cue-reactivity task, we demonstrated abnormal patterns of subjective response and brain reactivity in heroin-dependent individuals. However, whether the changes in cue-induced brain response were related to relapse was unknown. In a prospective study, we recruited 49 heroin-dependent patients under methadone maintenance treatment, a gold standard treatment (average daily dose 41.8 ± 16.0 mg), and 20 healthy subjects to perform the heroin cue-reactivity task during fMRI. The patients' subjective craving was evaluated. They participated in a follow-up assessment for 3 months, during which heroin use was assessed and relapse was confirmed by self-reported relapse or urine toxicology. Differences between relapsers and non-relapsers were analyzed with respect to the results from heroin-cue responses. Compared with healthy subjects, relapsers and non-relapsers commonly demonstrated significantly increased brain responses during the processing of heroin cues in the mesolimbic system, prefrontal regions and visuospatial-attention regions. However, compared with non-relapsers, relapsers demonstrated significantly greater cue-induced craving and the brain response mainly in the bilateral nucleus accumbens/subcallosal cortex and cerebellum. Although the cue-induced heroin craving was low in absolute measures, the change in craving positively correlated with the activation of the nucleus accumbens/subcallosal cortex among the patients. These findings suggest that in treatment-seeking heroin-dependent individuals, greater cue-induced craving and greater specific regional activations might be related to reward/craving and memory retrieval processes. These responses may predict relapse and represent important targets for the development of new treatment for heroin addiction.
Abnormal salience attribution is implicated in heroin addiction. Previously, combining functional magnetic resonance imaging (fMRI) and a drug cue‐reactivity task, we demonstrated abnormal patterns of subjective response and brain reactivity in heroin‐dependent individuals. However, whether the changes in cue‐induced brain response were related to relapse was unknown. In a prospective study, we recruited 49 heroin‐dependent patients under methadone maintenance treatment, a gold standard treatment (average daily dose 41.8 ± 16.0 mg), and 20 healthy subjects to perform the heroin cue‐reactivity task during fMRI. The patients' subjective craving was evaluated. They participated in a follow‐up assessment for 3 months, during which heroin use was assessed and relapse was confirmed by self‐reported relapse or urine toxicology. Differences between relapsers and non‐relapsers were analyzed with respect to the results from heroin‐cue responses. Compared with healthy subjects, relapsers and non‐relapsers commonly demonstrated significantly increased brain responses during the processing of heroin cues in the mesolimbic system, prefrontal regions and visuospatial‐attention regions. However, compared with non‐relapsers, relapsers demonstrated significantly greater cue‐induced craving and the brain response mainly in the bilateral nucleus accumbens/subcallosal cortex and cerebellum. Although the cue‐induced heroin craving was low in absolute measures, the change in craving positively correlated with the activation of the nucleus accumbens/subcallosal cortex among the patients. These findings suggest that in treatment‐seeking heroin‐dependent individuals, greater cue‐induced craving and greater specific regional activations might be related to reward/craving and memory retrieval processes. These responses may predict relapse and represent important targets for the development of new treatment for heroin addiction. Whether abnormal salience attribution is related to relapse to heroin use was unknown. In a 3‐month follow‐up prospective cue response fMRI study, we found that compared with nonrelapsers, relapsers demonstrated significantly greater cue‐induced craving and the brain response mainly in the bilateral nucleus accumbens/subcallosal cortex and cerebellum. These findings suggest that, greater cue‐induced craving and activations in reward/craving and memory retrieval related regions may predict relapse and represent important targets for the development of new treatment for heroin addiction.
Author Li, Zhe
Wang, Wei
Wang, Lina
Li, Yongbin
Li, Wei
Zhang, Yi
Liu, Yijun
Wang, Hanyue
Zheng, Ying
Tian, Jie
Wang, Yarong
Li, Qiang
Chang, Haifeng
Zhu, Jia
Fan, Min
Gold, Mark S.
Yan, Xuejiao
Zhang, Dongsheng
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/25214465$$D View this record in MEDLINE/PubMed
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ContentType Journal Article
Copyright 2014 Society for the Study of Addiction
2014 Society for the Study of Addiction.
2015 Society for the Study of Addiction
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– notice: 2014 Society for the Study of Addiction.
– notice: 2015 Society for the Study of Addiction
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ISSN 1355-6215
1369-1600
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IsPeerReviewed true
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Issue 5
Keywords fMRI
heroin addiction
relapse
Craving
Language English
License 2014 Society for the Study of Addiction.
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Notes istex:42F35D9F178C2EC6350D71BF2E00230153F81691
Figure S1 The differences relating to the 'heroin-related > neutral cues' contrast between heroin-dependent patients and healthy controls (P < 0.05, corrected for Monte Carlo simulations correction). R, right, L, leftFigure S2 The differences relating to the 'heroin-related > neutral cues' contrast between relapsers and healthy controls (P < 0.05, corrected for Monte Carlo simulations correction). R, right, L, leftFigure S3 The differences relating to the 'heroin-related > neutral cues' contrast between nonrelapsers and healthy controls (P < 0.05, corrected for Monte Carlo simulations correction). R, right, L, leftTable S1 Activated brain regions for the relapser compared with control group in response to heroin-related > neutral cues Table S2 Activated brain regions for the nonrelapsers compared with control group in response to heroin-related > neutral cues
National Natural Science Foundation of China - No. 81201081; No. 81371532; No. 81071142; No. 81071143; No. 81271549; No. 61131003
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PublicationTitle Addiction biology
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John Wiley & Sons, Inc
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– name: John Wiley & Sons, Inc
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References_xml – reference: Knapp CM, Tozier L, Pak A, Ciraulo DA, Kornetsky C (2009) Deep brain stimulation of the nucleus accumbens reduces ethanol consumption in rats. Pharmacol Biochem Behav 92:474-479.
– reference: Due DL, Huettel SA, Hall WG, Rubin DC (2002) Activation in mesolimbic and visuospatial neural circuits elicited by smoking cues: evidence from functional magnetic resonance imaging. Am J Psychiatry 159:954-960.
– reference: Zijlstra F, Veltman DJ, Booij J, van den Brink W, Franken IH (2009) Neurobiological substrates of cue-elicited craving and anhedonia in recently abstinent opioid-dependent males. Drug Alcohol Depend 99:183-192.
– reference: Janes AC, Pizzagalli DA, Richardt S, deB Frederick B, Chuzi S, Pachas G, Culhane MA, Holmes AJ, Fava M, Evins AE, Kaufman MJ (2010) Brain reactivity to smoking cues prior to smoking cessation predicts ability to maintain tobacco abstinence. Biol Psychiatry 67:722-729.
– reference: Tiffany ST, Carter BL (1998) Is craving the source of compulsive drug use? J Psychopharmacol 12:23-30.
– reference: Fatseas M, Denis C, Massida Z, Verger M, Franques-Reneric P, Auriacombe M (2011) Cue-induced reactivity, cortisol response and substance use outcome in treated heroin dependent individuals. Biol Psychiatry 70:720-727.
– reference: Franklin TR, Wang Z, Wang J, Sciortino N, Harper D, Li Y, Ehrman R, Kampman K, O'Brien CP, Detre JA, Childress AR (2007) Limbic activation to cigarette smoking cues independent of nicotine withdrawal: a perfusion fMRI study. Neuropsychopharmacology 32:2301-2309.
– reference: Beck AT, Steer RA, Ball R, Ranieri W (1996) Comparison of Beck Depression Inventories -IA and -II in psychiatric outpatients. J Pers Assess 67:588-597.
– reference: Yang Z, Xie J, Shao YC, Xie CM, Fu LP, Li DJ, Fan M, Ma L, Li SJ (2009) Dynamic neural responses to cue-reactivity paradigms in heroin-dependent users: an fMRI study. Hum Brain Mapp 30:766-775.
– reference: Carbo-Gas M, Vazquez-Sanroman D, Aguirre-Manzo L, Coria-Avila GA, Manzo J, Sanchis-Segura C, Miquel M (2014) Involving the cerebellum in cocaine-induced memory: pattern of cFos expression in mice trained to acquire conditioned preference for cocaine. Addict Biol 19:61-76.
– reference: Li Q, Wang Y, Zhang Y, Li W, Yang W, Zhu J, Wu N, Chang H, Zheng Y, Qin W, Zhao L, Yuan K, Liu J, Wang W, Tian J (2012) Craving correlates with mesolimbic responses to heroin-related cues in short-term abstinence from heroin: an event-related fMRI study. Brain Res 1469:63-72.
– reference: Spanagel R (2003) Alcohol addiction research: from animal models to clinics. Best Pract Res Clin Gastroenterol 17:507-518.
– reference: Corbit LH, Muir JL, Balleine BW (2001) The role of the nucleus accumbens in instrumental conditioning: evidence of a functional dissociation between accumbens core and shell. J Neurosci 21:3251-3260.
– reference: Kuhn J, Bauer R, Pohl S, Lenartz D, Huff W, Kim EH, Klosterkoetter J, Sturm V (2009) Observations on unaided smoking cessation after deep brain stimulation of the nucleus accumbens. Eur Addict Res 15:196-201.
– reference: Langleben DD, Ruparel K, Elman I, Busch-Winokur S, Pratiwadi R, Loughead J, O'Brien CP, Childress AR (2008) Acute effect of methadone maintenance dose on brain FMRI response to heroin-related cues. Am J Psychiatry 165:390-394.
– reference: Hamilton M (1959) The assessment of anxiety states by rating. Br J Med Psychol 32:50-55.
– reference: Volkow ND, Wang GJ, Fowler JS, Tomasi D, Telang F (2011) Addiction: beyond dopamine reward circuitry. Proc Natl Acad Sci USA 108:15037-15042.
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Snippet Abnormal salience attribution is implicated in heroin addiction. Previously, combining functional magnetic resonance imaging (fMRI) and a drug cue‐reactivity...
Abnormal salience attribution is implicated in heroin addiction. Previously, combining functional magnetic resonance imaging ( fMRI ) and a drug cue‐reactivity...
Abnormal salience attribution is implicated in heroin addiction. Previously, combining functional magnetic resonance imaging (fMRI) and a drug cue-reactivity...
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SubjectTerms Adult
Brain - drug effects
Brain - physiopathology
Brain Mapping
China
Craving
Cues
Female
fMRI
Follow-Up Studies
heroin addiction
Heroin Dependence - physiopathology
Heroin Dependence - rehabilitation
History, Ancient
Humans
Magnetic Resonance Imaging
Male
Methadone - therapeutic use
Opiate Substitution Treatment
Predictive Value of Tests
Prospective Studies
Recurrence
relapse
Reproducibility of Results
Title Predicting subsequent relapse by drug-related cue-induced brain activation in heroin addiction: an event-related functional magnetic resonance imaging study
URI https://api.istex.fr/ark:/67375/WNG-SFHRNC15-Q/fulltext.pdf
https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fadb.12182
https://www.ncbi.nlm.nih.gov/pubmed/25214465
https://www.proquest.com/docview/1703125750
https://www.proquest.com/docview/1703705601
https://www.proquest.com/docview/1709180663
Volume 20
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