Double-blind randomized parallel-group clinical trial of efficacy of the combination fluoxetine plus modafinil versus fluoxetine plus placebo in the treatment of major depression

• Published in: Depression and anxiety Vol. 28; no. 4; pp. 297 - 302
• Main Authors: Abolfazli, Roya, Hosseini, Mahdi, Ghanizadeh, Ahmad, Ghaleiha, Ali, Tabrizi, Mina, Raznahan, Maedeh, Golalizadeh, Mousa, Akhondzadeh, Shahin
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.04.2011
• Subjects: Adult; Affective disorders; Antidepressive Agents, Second-Generation - adverse effects; Antidepressive Agents, Second-Generation - therapeutic use; Anxiety; Benzhydryl Compounds - adverse effects; Benzhydryl Compounds - therapeutic use; BID protein; Central Nervous System Stimulants - adverse effects; Central Nervous System Stimulants - therapeutic use; clinical trial; Clinical trials; Depression; Depressive Disorder, Major - diagnosis; Depressive Disorder, Major - drug therapy; Depressive Disorder, Major - psychology; Double-Blind Method; Drug Therapy, Combination; Female; Fluoxetine; Fluoxetine - adverse effects; Fluoxetine - therapeutic use; Humans; Iran; major depression; Male; Middle Aged; modafinil; Personality Inventory - statistics & numerical data; Psychometrics; Side effects; Young Adult; Iran

Background: There is growing interest in the identification of novel therapeutic agents for the treatment of affective disorders, with modafinil being one promising substance. The purpose of the present investigation was to compare the efficacy of a combination of fluoxetine plus modafinil with that...