Subphenotypes of nonsteroidal antiinflammatory disease‐exacerbated respiratory disease identified by latent class analysis

• Published in: Allergy (Copenhagen) Vol. 75; no. 4; pp. 831 - 840
• Main Authors: Celejewska‐Wójcik, Natalia, Wójcik, Krzysztof, Ignacak‐Popiel, Maria, Ćmiel, Adam, Tyrak, Katarzyna, Gielicz, Anna, Kania, Aleksander, Nastałek, Paweł, Sanak, Marek, Mastalerz, Lucyna
• Format: Journal Article
• Language: English
• Published: Denmark Blackwell Publishing Ltd 01.04.2020; John Wiley and Sons Inc
• Subjects: Adult; Anti-Inflammatory Agents, Non-Steroidal - adverse effects; Aspirin; Asthma; Chromatography; Disease control; Eicosanoids; Eosinophilia; Female; Gas chromatography; Humans; Hypersensitivity; induced sputum; Inflammation; Latent Class Analysis; Leukocytes (eosinophilic); Leukotriene E4; Liquid chromatography; Male; Mass spectroscopy; Middle Aged; Nonsteroidal anti-inflammatory drugs; NSAID‐exacerbated respiratory disease; Original; ORIGINAL ARTICLES; Patients; phenotype; Phenotypes; Prostaglandin E2; Respiration Disorders; Respiratory diseases; Respiratory function; Respiratory tract; Respiratory tract diseases; Secretions; Sputum; Steroid hormones; phenotype; induced sputum; NSAID-exacerbated respiratory disease; eicosanoids; latent class analysis

Background Induced sputum (IS) allows to measure mediators of asthmatic inflammation in bronchial secretions. NSAID‐exacerbated respiratory disease (NERD) is recognized as a distinct asthma phenotype, usually with a severe course, eosinophilic airway inflammation, and increased production of pro‐inf...