Serum Fibroblast Growth Factor 21 Is Associated with Adverse Lipid Profiles and γ-Glutamyltransferase But Not Insulin Sensitivity in Chinese Subjects

• Published in: The journal of clinical endocrinology and metabolism Vol. 94; no. 6; pp. 2151 - 2156
• Main Authors: Li, Huating, Bao, Yuqian, Xu, Aimin, Pan, Xiaoping, Lu, Junxi, Wu, Haiya, Lu, Huijuan, Xiang, Kunsan, Jia, Weiping
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Oxford University Press 01.06.2009; Copyright by The Endocrine Society; Endocrine Society
• Subjects: Adipose tissue; Adiposity - physiology; Adult; Animal models; Biological and medical sciences; Blood Glucose - metabolism; China; Cholesterol; Endocrinopathies; Fasting; Feeding. Feeding behavior; Female; Fibroblast Growth Factors - blood; Fibroblasts; Fundamental and applied biological sciences. Psychology; gamma-Glutamyltransferase - blood; Glucose; Glucose Clamp Technique; Glucose Intolerance - blood; Glucose metabolism; Glucose tolerance; Glucose Tolerance Test; Growth factors; Humans; Insulin; Insulin Resistance - physiology; Insulin secretion; Laboratory testing; Lipid metabolism; Lipid Metabolism - physiology; Lipids; Lipids - blood; Liver; Liver Diseases - blood; Liver Diseases - metabolism; Male; Medical sciences; Metabolism; Middle Aged; Sensitivity analysis; Serum levels; Triglycerides; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Vertebrates: endocrinology; γ-Glutamyltransferase; Asia; China; Human; Acyltransferases; Fibroblast growth factor; Obesity; Pancreatic hormone; Asiatic; Nutrition; Enzyme; Insulin sensitivity; Transferases; Nutrition disorder; Lipids; Metabolic diseases; Aminoacyltransferases; Insulin; γ-Glutamyltransferase; Cause; Chinese; Serum; Endocrinology; Nutritional status

Objective: Fibroblast growth factor (FGF) 21, a hormone primarily secreted by liver, has recently been shown to have beneficial effects on glucose and lipid metabolism and insulin sensitivity in animal models. This study investigated the association of serum FGF21 levels with insulin secretion and s...