Adipogenic Impairment of Adipose Tissue–Derived Mesenchymal Stem Cells in Subjects With Metabolic Syndrome: Possible Protective Role of FGF2

• Published in: The journal of clinical endocrinology and metabolism Vol. 102; no. 2; pp. 478 - 487
• Main Authors: Oliva-Olivera, Wilfredo, Coín-Aragüez, Leticia, Lhamyani, Said, Clemente-Postigo, Mercedes, Torres, Juan Alcaide, Bernal-López, Maria Rosa, El Bekay, Rajaa, Tinahones, Francisco José
• Format: Journal Article
• Language: English
• Published: Washington, DC Endocrine Society 01.02.2017; Copyright Oxford University Press; Oxford University Press
• Subjects: Adipocytes; Adipogenesis - genetics; Adipogenesis - physiology; Adipose tissue; Adipose Tissue - metabolism; Adipose Tissue - pathology; Adult; Anthropometry - methods; Apoptosis; Apoptosis - physiology; Bariatric Surgery; Body fat; Cell Differentiation - physiology; Cell Proliferation; Cell surface; Cholecystectomy; Colony-Forming Units Assay; Enzyme-linked immunosorbent assay; Fibroblast growth factor 2; Fibroblast Growth Factor 2 - metabolism; Fibroblast Growth Factor 2 - physiology; Fibroblasts; Gastrointestinal surgery; Gene expression; Gene Expression Regulation - physiology; Glucose Transporter Type 4 - biosynthesis; Glucose Transporter Type 4 - genetics; Growth factors; Humans; Mesenchymal stem cells; Mesenchymal Stromal Cells - metabolism; Mesenchymal Stromal Cells - pathology; Mesenchymal Stromal Cells - physiology; Mesenchyme; Metabolic syndrome; Metabolic Syndrome - genetics; Metabolic Syndrome - metabolism; Metabolic Syndrome - pathology; Middle Aged; Obesity, Morbid - metabolism; Obesity, Morbid - pathology; Obesity, Morbid - surgery; Patients; Perilipin-1 - biosynthesis; Perilipin-1 - genetics; Polymerase chain reaction; RNA, Messenger - genetics; Smad7 protein; Stem cells; Surgery; Western blotting

Context:The decreased expansion capacity of adipose tissue plays a crucial role in the onset of disorders associated with metabolic syndrome.Objective:The aim of this study was to examine the state of adipose tissue-derived mesenchymal stem cells (ASCs) from obese subjects with different metabolic p...