Down-regulation of TYK2, CBLB and LMP7 genes expression in relapsing-remitting multiple sclerosis patients treated with interferon-beta

• Published in: Journal of neuroimmunology Vol. 314; pp. 24 - 29
• Main Authors: Mazdeh, Mehrdokht, Moradi, Najmeh, Khoshroo, Elnaz, Shayesteh, Zahra, Taheri, Mohammad, Sayad, Arezou, Omrani, Mir Davood, Hajilooi, Mehrdad, Roshanaei, Ghodratollah, Solgi, Ghasem
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.01.2018
• Subjects: Adaptor Proteins, Signal Transducing - blood; Adaptor Proteins, Signal Transducing - drug effects; Adjuvants, Immunologic - therapeutic use; Adult; CBLB; Cytokines - blood; Cytokines - drug effects; Cytokines - immunology; Down-Regulation; Female; Gene; Humans; Interferon-beta; Interferon-beta - therapeutic use; LMP7; Male; Multiple sclerosis; Multiple Sclerosis, Relapsing-Remitting - blood; Multiple Sclerosis, Relapsing-Remitting - drug therapy; Multiple Sclerosis, Relapsing-Remitting - immunology; Proteasome Endopeptidase Complex - blood; Proteasome Endopeptidase Complex - drug effects; Proto-Oncogene Proteins c-cbl - blood; Proto-Oncogene Proteins c-cbl - drug effects; TYK2; TYK2 Kinase - blood; TYK2 Kinase - drug effects; Multiple sclerosis; CBLB; Interferon-beta; TYK2; LMP7; Gene

This study aimed to examine the expression of TYK2, CBLB and LMP7 genes at both mRNA and protein levels in relapsing-remitting MS (RRMS) patients in compare with healthy controls. Seventy-eight RRMS patients treated with IFNβ-1a and 79 age- and ethnic-matched healthy subjects were studied. The mRNA...