Transcriptomic Evidence for Alterations in Astrocytes and Parvalbumin Interneurons in Subjects With Bipolar Disorder and Schizophrenia

• Published in: Biological psychiatry (1969) Vol. 84; no. 11; pp. 787 - 796
• Main Authors: Toker, Lilah, Mancarci, Burak Ogan, Tripathy, Shreejoy, Pavlidis, Paul
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2018
• Subjects: Astrocytes - metabolism; Biomarkers; Bipolar Disorder - genetics; Bipolar Disorder - metabolism; Brain - metabolism; Brain - physiopathology; Case-Control Studies; Cell types; Cortex; Functional Laterality; Gene expression; Humans; Interneurons - metabolism; Meta-analysis; Mitochondria; Parvalbumins - metabolism; Psychiatric disorders; Schizophrenia - genetics; Schizophrenia - metabolism; Transcriptome; Mitochondria; Gene expression; Cell types; Psychiatric disorders; Cortex; Meta-analysis

High-throughput expression analyses of postmortem brain tissue have been widely used to study bipolar disorder and schizophrenia. However, despite the extensive efforts, no consensus has emerged as to the functional interpretation of the findings. We hypothesized that incorporating information on ce...