Cigarette Smoking Is Associated With Increased Human Monocyte Adhesion to Endothelial Cells: Reversibility With Oral l-Arginine but Not Vitamin C

• Published in: Journal of the American College of Cardiology Vol. 29; no. 3; pp. 491 - 497
• Main Authors: Adams, Mark R, Jessup, Wendy, Celermajer, David S
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.03.1997; Elsevier Science
• Subjects: Adult; Arginine - pharmacology; Ascorbic Acid - pharmacology; Biological and medical sciences; Cell Adhesion - drug effects; Cells, Cultured; Endothelium, Vascular - physiology; Female; Humans; Intercellular Adhesion Molecule-1 - metabolism; Male; Medical sciences; Monocytes - physiology; Smoking - physiopathology; Tobacco, tobacco smoking; Toxicology; VCAM-1; TNF-alpha; ICAM-1; HBSS; EDTA; RPMI; IL-1beta; HUVECs; IL-6; ELISA; Human; Endothelial cell; Ascorbic acid; Monocyte; Toxicity; Tobacco smoking; Exploration; Supplemented diet; Gene expression; Adhesion; In vitro; Treatment; Arginine

Objectives. This study sought to assess the effect of cigarette smoking on adhesion of human monocytes to human endothelial cells and to measure the effect of l-arginine and vitamin C supplementation on this interaction. Background. Cigarette smoking has been associated with abnormal endothelial fun...